DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmrt11E and Dmrt3

DIOPT Version :9

Sequence 1:	NP_511146.2	Gene:	dmrt11E / 32291	FlyBaseID:	FBgn0030477	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_796334.2	Gene:	Dmrt3 / 240590	MGIID:	2449470	Length:	476	Species:	Mus musculus

Alignment Length:	250	Identity:	81/250 - (32%)
Similarity:	123/250 - (49%)	Gaps:	32/250 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 LLRTPKCARCRNHGVISCVKGHKRLCRWRECCCPNCQLVVDRQRVMAAQVALRRQQTMEALEATA 180
            |.|||||||||||||:|.:|||||.||:::|.|..|.|:::|||||||||||||||..|:||:..
Mouse    23 LQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANESLESLI 87

  Fly   181 SST----------KSTGVTTASANNSSSSEGEDSLSSTSPPPAHSHPHSHSHPTSCVS-NSSSSS 234
            ..:          .....|.|:|:.||.:      |..|.|||...|.:.....:.:. .:....
Mouse    88 PDSLRALPGPPPPGDAAATAATASQSSPA------SQASQPPAPPRPTAELAAAAALRWVAEPQP 146

  Fly   235 ATRQALMAQKRIYKQRLRSLQQSTLHITAAM--EEYKQRFPTFSSPLMERMRKRRAFADPELNHV 297
            .|..|.:|:..:.::|:.. ..||.:...|.  ::..||    |||  :.::.:..|. ||...:
Mouse   147 GTLPAQLAKPDLTEERVGD-SSSTDNTAEAFSDKDTDQR----SSP--DVVKSKNCFT-PESPEI 203

  Fly   298 MEATLGGNALYFATVAAAAAACAP-VHQEQ-HIYHPMPP---TIPLTIPPTNPAM 347
            :....||.|:........:...:| .|.|| |:....|.   ::|.::....|.:
Mouse   204 VSVDEGGYAVQKNGGNPESCPDSPKYHAEQSHLLIEGPSGTVSLPFSLKANRPPL 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmrt11E	NP_511146.2	DM	118..164	CDD:279137	31/45 (69%)
Dmrt3	NP_796334.2	DM	25..71	CDD:366283	31/45 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..130		11/46 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..195		12/54 (22%)
		CUE_DMA_DMRTA3	253..295	CDD:270602	1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D383821at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820