Protein Alignment Syt12 and SYTL3

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001229313.1
• Gene: SYTL3 / 94120
• HGNCID: 15587
• Length: 610
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 127/581 - (21%)
• Similarity: 205/581 - (35%)
• Gaps: 214/581 - (36%)

  Fly   273 FLCESTEQIPSNPISEPLNA-TVASLEKTTISTSECTPITAPLETPNGPIS----TDTPSTIHHN 332
            |..|..::.|:....|.:.. .:.|.:|  :|.....|.|.|      |:|    :.:|..:...
Human   120 FYEERAKKFPTGGKHETVGGQLLQSYQK--LSKISVVPPTPP------PVSESQCSRSPGRLQEF 176

  Fly   333 G-----NPFVER--ESLSSRLLKIHNTTNPFTG----------------------------LSQR 362
            |     |..||.  .||::.:.|:..:.|..|.                            .:::
Human   177 GQFRGFNKSVENLFLSLATHVKKLSKSQNDMTSEKHLLATGPRQCVGQTERRSQSDTAVNVTTRK 241

  Fly   363 VKGPHLLQKTISEDYLFRKLGVNCPMANGNGTGPGSGHVNGNGNGTWSFGRSLLRQD-------- 419
            |..|.:|:....||          |..:.|                     .:|:|.
Human   242 VSAPDILKPLNQED----------PKCSTN---------------------PILKQQNLPSSPAP 275

  Fly   420 STLSLGMGLGRRNSSQVSLDSHAGSVPGSMDGINLERAISCDSVTSDSTLFLDQLDQPYTQITGY 484
            ||:..|   |.|:.|.:|:||....: |:.|..|                           :||.
Human   276 STIFSG---GFRHGSLISIDSTCTEM-GNFDNAN---------------------------VTGE 309

  Fly   485 LCVGLNYDQMSISNEGMELTVSVL------EAKGLICPFSVESLDTFVRIYLVPDH--PGAMQTK 541
            :...::|   ......:|:.:...      |.|...|       :.:|:.||:||.  .|..:|.
Human   310 IEFAIHY---CFKTHSLEICIKACKNLAYGEEKKKKC-------NPYVKTYLLPDRSSQGKRKTG 364

  Fly   542 VVKGTLTPSYNESFDF-----WLHKRQARHSLWFHLYHNGPAHTLIGEAEMEIGEMPRPITTWIP 601
            |.:.|:.|::.|:..:     .|..||.:.|:|    |.|   ||  ...:.:||:..|:.|| .
Human   365 VQRNTVDPTFQETLKYQVAPAQLVTRQLQVSVW----HLG---TL--ARRVFLGEVIIPLATW-D 419

  Fly   602 LSDSRKCNARW------------------GELMFSLS-YLPTAER-----------------LTI 630
            ..||...:.||                  |||..... .||:..|                 |.:
Human   420 FEDSTTQSFRWHPLRAKAEKYEDSVPQSNGELTVRAKLVLPSRPRKLQEAQEGTDQPSLHGQLCL 484

  Fly   631 VVVKARNLKL--DGEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIFS- 692
            ||:.|:||.:  ||         |::| |||..|...|::.|:.::.:.||...|.:..|.:||
Human   485 VVLGAKNLPVRPDG---------TLNS-FVKGCLTLPDQQKLRLKSPVLRKQACPQWKHSFVFSG 539

  Fly   693 VPPPSLTTTQLRVTV-----FGVTTS--GVTPLGH----IVAG-SCAVGKGLRHWHQMLSS 741
            |.|..|..:.|.:||     ||:...  |.|.||.    .|.| :|::.|  ..|.::|||
Human   540 VTPAQLRQSSLELTVWDQALFGMNDRLLGGTRLGSKGDTAVGGDACSLSK--LQWQKVLSS 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	28/111 (25%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	49/181 (27%)
SYTL3	NP_001229313.1	PHD_SF	8..123	CDD:473978	1/2 (50%)
		FYVE_Slp3	60..108	CDD:277304
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..239		0/19 (0%)
		C2A_SLP-3	307..434	CDD:176038	36/146 (25%)
		C2B_SLP_1-2-3-4	448..610	CDD:175987	48/163 (29%)