Protein Alignment Syt12 and SYT7

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_011543637.1
• Gene: SYT7 / 9066
• HGNCID: 11514
• Length: 692
• Species: Homo sapiens
• Alignment Length: 833
• Identity: 193/833 - (23%)
• Similarity: 310/833 - (37%)
• Gaps: 246/833 - (29%)

  Fly     1 MMSFTITLALLLLAVLILGILFACHCLGPRAANWMRMRSSKEEKIGLSNHKQKLFHANGYMASIQ 65
            ::|..||:: |.:.|::.|:   ||        |.:.:..|..|..|..           :.:..
Human    25 LVSAIITVS-LSVTVVLCGL---CH--------WCQRKLGKRYKNSLET-----------VGTPD 66

  Fly    66 SG---SEFLLSTSGSFKRFDTIDKEDYNRSQQTHQTHL-------FLMN-------GGGAVSITG 113
            ||   ||        .|..:.:|::.:|.::.|.|...       |::|       |...:|:.|
Human    67 SGRGRSE--------KKAINDLDRDFWNNNESTVQQKWSSYPPKEFILNISPYAPYGDPRLSLNG 123

  Fly   114 S--SSALQATTAMWHLPRSGIKIPPPPDRPAPSPNSAAAAGKTVTFSLSQVNEVIMPGEQVTSND 176
            :  |.|..|..|...:.|.|    ...::|||.|                     .|||
Human   124 TLLSGAKVAAAAGLAVEREG----RLGEKPAPVP---------------------PPGE------ 157

  Fly   177 QERRSCLRQNGGTAGGAGGGGVLPQPLEAPPPPRLTASTSVNLSGTAIPRPIAKRQVSTQPANNS 241
                ..||..|......|.||                                          .:
Human   158 ----DALRSGGAAPSEPGSGG------------------------------------------KA 176

  Fly   242 GCQPEQTVVTPMREGERKAPALKRRNSSTNPFLCESTEQIPSNPISEPLNATVASLEKTTISTSE 306
            |....:||.:.:..|:......:....||    ..:.|.|||: ..||                :
Human   177 GRGRWRTVQSHLAAGKLNLSNFEDSTLST----ATTLESIPSS-TGEP----------------K 220

  Fly   307 C-TPITAPLETPNGPISTDTPSTIHHNG-NPFVERESLSSRLLKIHNTTNPFTGLSQRVKGPHLL 369
            | .|.|...:.     |...|.:.|..| .|.....|.|...|:.|..:.|  |.:.|..|....
Human   221 CQRPRTLMRQQ-----SLQQPLSQHQRGRQPSQPTTSQSLGQLQAHMASAP--GPNPRAYGRGQA 278

  Fly   370 QKTISEDYLFRKLGVNCPMANGNGTGPGS-----GHVNGNGNGTWSF--GRSLLRQDSTLSLGMG 427
            ::..|....:|..|      ..:.:.|||     |.:...|....||  ||.::     |||.:|
Human   279 RQGTSAGSKYRAAG------GRSRSNPGSWDHVVGQIRNRGLDMKSFLEGRMVV-----LSLVLG 332

  Fly   428 L---------------GRRNSSQVSLDSH--AGS-------VPGSMDGINLERAISCDSVTSD-- 466
            |               |.:.:.....|..  ||.       |||.......:|.....|..||
Human   333 LSEQDDFANIPDLQNPGTQQNQNAQGDKRLPAGGKAVNTAPVPGQTPHDESDRRTEPRSSVSDLV 397

  Fly   467 STLFLDQL--------DQPYTQITG------YLCVGLNYDQMSISNEGMELTVSVLEAKGLICPF 517
            ::|..:.|        |:.:...:.      ...||.|:.:.:       |||.:::|:.|....
Human   398 NSLTSEMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQEST-------LTVKIMKAQELPAKD 455

  Fly   518 SVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESFDF--WLHKRQARHSLWFHL--YHNGPA 578
            ...:.|.||:|||:||....::|||.:..|.|.:||:|.|  :.:::..:..|:..:  |.....
Human   456 FSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSR 520

  Fly   579 HTLIGEAEMEIG--EMPRPITTWIPLSDSRKCNARWGELMFSLSYLPTAERLTIVVVKARNLK-L 640
            :..|||..:.:.  ::.:..|.|..|......:...|||:.||.|.|:|..:.:.::|||||| :
Human   521 NDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNPSANSIIVNIIKARNLKAM 585

  Fly   641 D-GEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIFSVPPPSLTTTQLR 704
            | |....|         :|||:||.||::|.||:|...:::.:||||||..|.:|...|..|.:.
Human   586 DIGGTSDP---------YVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFDIPTEKLRETTII 641

  Fly   705 VTVFG---VTTSGVTPLGHIVAGSCAVGKG-LRHWHQMLSSLRKPVAMWHVLR 753
            :||..   ::.:.|  :|.|.. |...|.| ::||..|::..|:|||.||.|:
Human   642 ITVMDKDKLSRNDV--IGKIYL-SWKSGPGEVKHWKDMIARPRQPVAQWHQLK 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	29/104 (28%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	55/146 (38%)
SYT7	XP_011543637.1	PHA03307	<149..>316	CDD:223039	49/273 (18%)
		C2A_Synaptotagmin-7	424..548	CDD:176032	33/130 (25%)
		C2B_Synaptotagmin-7	556..691	CDD:176050	55/146 (38%)