Protein Alignment Syt12 and SYT8

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001277261.2
• Gene: SYT8 / 90019
• HGNCID: 19264
• Length: 402
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 99/339 - (29%)
• Similarity: 155/339 - (45%)
• Gaps: 55/339 - (16%)

  Fly   431 RNSSQVSLDSHAGS-----VPGSMDGINLERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLN 490
            |:...|.|.|..|:     |...:||:        :|...|:            |..|.|.:.|.
Human    83 RDKESVGLGSARGTTTTHLVQPDVDGL--------ESSPGDA------------QQWGCLQLSLE 127

  Fly   491 YDQMSISNEGMELTVSVLEAKGLICPFSVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESF 555
            :|..|     .|:.|.:.:|..|....:|   |.:.|:.:........:|||.:|||.|.::|:.
Human   128 FDFGS-----QEIRVGLRQAADLRPGGTV---DPYARVSVSTQAGHRHETKVHRGTLCPVFDETC 184

  Fly   556 DFWLHKRQAR---HSLWFHLYH--NGPAHTLIGEAEMEIG--EMPRPITTWIPLSDSRKCN-ARW 612
            .|  |..||.   .:|...|::  ....|..:||..:.:|  ::...:..|..|....... .:.
Human   185 CF--HIPQAELPGATLQVQLFNFKRFSGHEPLGELRLPLGTVDLQHVLEHWYLLGPPAATQPEQV 247

  Fly   613 GELMFSLSYLPTAERLTIVVVKARNLKLDGEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLK 677
            |||.|||.|:|::.|||:||::||.|:       |..||.    :|||.||...||..|::|:.|
Human   248 GELCFSLRYVPSSGRLTVVVLEARGLR-------PGLAEP----YVKVQLMLNQRKWKKRKTATK 301

  Fly   678 RKDRSPIFNESMIFSVPPPSLTTTQLRVTVFGVTTSGVT-PLGHIVAGSCAVGKGLRHWHQMLSS 741
            :...:|.|||:..|.||...:....|.:.|:..:....| |:|.:..|:.|.|:.|:||..||:.
Human   302 KGTAAPYFNEAFTFLVPFSQVQNVDLVLAVWDRSLPLRTEPVGKVHLGARASGQPLQHWADMLAH 366

  Fly   742 LRKPVAMWHVLRRA 755
            .|:|:|..|.||.|
Human   367 ARRPIAQRHPLRPA 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	25/105 (24%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	53/141 (38%)
SYT8	NP_001277261.2	C2	120..233	CDD:472691	30/122 (25%)
		C2	248..377	CDD:472691	53/139 (38%)