DRSC/TRiP Functional Genomics Resources

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Protein Alignment Syt12 and SYT3

DIOPT Version :10

Sequence 1:NP_572878.1 Gene:Syt12 / 32290 FlyBaseID:FBgn0261085 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_115674.1 Gene:SYT3 / 84258 HGNCID:11511 Length:590 Species:Homo sapiens


Alignment Length:661 Identity:159/661 - (24%)
Similarity:227/661 - (34%) Gaps:263/661 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   139 DRPAPS-------PNSAAAAGKTVTFSLSQVNEVIMPGEQVTSNDQERRSCLRQNGGTAGGAGGG 196
            |.|.||       |.:||||              :..|.:.:....|..|        .||||.|
Human   155 DTPEPSYLDMDSYPEAAAAA--------------VAAGVKPSQTSPELPS--------EGGAGSG 197

  Fly   197 GVLPQPLEAPPPPRLTASTSVNLSGT----AIPRPIAKRQVSTQPANNSGCQPEQTVVTPMREGE 257
            .:|..|.....|...:.....:|:.|    |:|||:.::.:::||..:|               |
Human   198 LLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTSQPDPSS---------------E 247

  Fly   258 RKAPALKRRNSSTNPFLCESTEQIPSNPISEPLNATVASLEKTTISTSECTPITAPLETPNGPIS 322
            .:.|||                                                 ||..|.|.  
Human   248 ERPPAL-------------------------------------------------PLPLPGGE-- 261

  Fly   323 TDTPSTIHHNGNPFVERESLSSRLLKIHNTTNPFTGLSQRVKGPHLLQKTISEDYLFRKLGVNCP 387
                           |:..|..::                  .|.|.|                 
Human   262 ---------------EKAKLIGQI------------------KPELYQ----------------- 276

  Fly   388 MANGNGTGPGSGHVNGNGNGTWSFGRSLLRQDSTLSLGMGLGRRNSSQVSLDSHAGSVPGSMDGI 452
                 ||||| |..:|.|.|:...|           .|...||                      
Human   277 -----GTGPG-GRRSGGGPGSGEAG-----------TGAPCGR---------------------- 302

  Fly   453 NLERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVLEAKGLICPF 517
                       .|.:..:|...||                          |.|.:|:|..|....
Human   303 -----------ISFALRYLYGSDQ--------------------------LVVRILQALDLPAKD 330

  Fly   518 SVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESFDFWLHKRQ-ARHSLWFHLY--HNGPAH 579
            |....|.:|:|||:||.....||||.:.||.|.:||:|.|.:...: |:..|.|.:|  .....|
Human   331 SNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRH 395

  Fly   580 TLIGEAE----MEIGEMP--RPITTWIPLSDSRKCNARWGELMFSLSYLPTAERLTIVVVKARNL 638
            .|||:..    :|:.|.|  ||:  |..:.:.....|..|||.|||.|||||.|||:.::||.||
Human   396 DLIGQVVLDNLLELAEQPPDRPL--WRDIVEGGSEKADLGELNFSLCYLPTAGRLTVTIIKASNL 458

  Fly   639 K---LDG-EQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIFSVPPPSLT 699
            |   |.| ..|           :||..|:.:.|::.|::||:|:...:|.:||:::|.|.|.|:.
Human   459 KAMDLTGFSDP-----------YVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVE 512

  Fly   700 TTQLRVTVFGVTTSGVTPLGH-IVAGSCAVG------KGLRHWHQMLSSLRKPVAMWHVLRRAVN 757
            ...|.:.|.....     :|| .|.|.|.||      .|..||.:||::.||||..||.|.....
Human   513 NVGLSIAVVDYDC-----IGHNEVIGVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQLVEEKT 572

  Fly   758 QPIFTGGAEAV 768
            ...||.|::.:
Human   573 VTSFTKGSKGL 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syt12NP_572878.1 C2 503..602 CDD:425499 38/107 (36%)
C2B_Synaptotagmin-12 612..753 CDD:176051 57/151 (38%)
SYT3NP_115674.1 Cysteine motif. /evidence=ECO:0000250|UniProtKB:O35681 10..34
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..220 20/86 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..260 10/89 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 273..295 11/44 (25%)
C2A_Synaptotagmin-1-5-6-9-10 299..424 CDD:176031 44/185 (24%)
C2B_Synaptotagmin-3-5-6-9-10 433..567 CDD:176048 57/149 (38%)
Blue background indicates that the domain is not in the aligned region.

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