Protein Alignment Syt12 and Sytl2

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001355807.1
• Gene: Sytl2 / 83671
• MGIID: 1933366
• Length: 2153
• Species: Mus musculus
• Alignment Length: 778
• Identity: 161/778 - (20%)
• Similarity: 263/778 - (33%)
• Gaps: 207/778 - (26%)

  Fly   110 SITGSSSALQATTAMWHLPRSGIKIPPPPD----RPAPS--------------------PNSAAA 150
            ::|.|.|||..:..|.|...|...:....:    ..|||                    |....|
Mouse  1435 TMTISPSALTGSCEMSHQLSSEFHLTEIQETVEKAEAPSVTESSFDVGLEKLLKEMSEGPCQLQA 1499

  Fly   151 AGK--TVTFSLSQVNEVIMPGE--------------QVTSNDQERR--SCLRQNGGTAGGAGGGG 197
            :|:  |:....|||.:....||              :|:.:..|.:  .|.:|.||.....|
Mouse  1500 SGRRDTLEKQPSQVEQAGFMGEIPHHILDGPGASKMKVSCSGLESQISQCDKQLGGDEAVTG--- 1561

  Fly   198 VLPQPL----------EAPPPPRLTASTSVNLSGT-AIPRPIAKRQV---STQPANNSGCQ--PE 246
                ||          |.|...:|.....:..:|| .......:.:|   .||.:...|.:  |:
Mouse  1562 ----PLIDVQDNKSGFEVPECSQLHEDHKIETNGTIQFVEDKGREKVITGETQASQEPGFEEAPK 1622

  Fly   247 QTVVTPMREG----ERKAPAL-------------KRRNSSTNPFLCESTEQIPSNPISEPLNATV 294
            :..|:..:..    |.|..|:             ||:.....|..|...|....|..|...|
Mouse  1623 EMSVSRNKHSIVLLETKGKAIKTREVKLVLATPYKRQEEEQGPEACSEYEFSDGNTSSNREN--- 1684

  Fly   295 ASLEKTTISTSECTPITAPLE------TPNGPISTDTPSTIHHNGNPFVERESLSSRLLKIHNTT 353
              ...|:.|..|.:|:...||      .|:..:. |.||.              ||...|:.|.
Mouse  1685 --WRNTSSSEEEHSPVLKTLERRAARKLPSKSLE-DIPSD--------------SSNQAKVDNL- 1731

  Fly   354 NPFTGLSQRVKGPHLLQKTISEDYLFRKLGVNCPMANGNGTGPGSGHVNGNGNGTWSFGRSLLRQ 418
                        |..|.::..:|   :|....   .:.|...||...|....:..:|....|.|.
Mouse  1732 ------------PEELVRSAEDD---QKADQE---PDTNECIPGISTVPSLPDNQFSHPDKLKRM 1778

  Fly   419 DSTLSLGMGLGRRNSSQVSLDSHAGS---------VPGSMDGINLERAISCDSVTSDSTLFLDQL 474
            ..::...:   :..|.....|:.:.|         .|.|:..::....::..|..|.|.:.:...
Mouse  1779 SKSVPAFL---QDESDDRETDTASESSYQLRRYKKSPSSLTNLSSSSGMTSLSSASGSVMSVYSG 1840

  Fly   475 DQPYTQITGYLCVGLNYDQMSISNEGMELTVSVLEAKGL-ICPFSVESLDTFVRIYLVPD--HPG 536
            |....::.|.:...|:|.: |:.    ||.|.|.:.|.| ......:..|.:|:.||:||  ..|
Mouse  1841 DFGNLEVKGSVQFALDYVE-SLK----ELHVFVAQCKDLAAADVKKQRSDPYVKTYLLPDKGKMG 1900

  Fly   537 AMQTKVVKGTLTPSYNESFDF-----WLHKRQARHSLWFHLYHNG--PAHTLIGEAEMEIGEMPR 594
            ..:|.|||.||.|.|||...:     :|..::...|:|    |..  ..::.:||.|::
Mouse  1901 KKKTLVVKKTLNPVYNEILRYKIERQFLKTQKLNLSVW----HRDTFKRNSFLGEVELD------ 1955

  Fly   595 PITTWIPLSDSRKCNARW-----------------GELMFSLSY---------LPTAERLTIVVV 633
             :.||...|...| ..:|                 ||:..:|.|         |||...:.|.|.
Mouse  1956 -LETWDWDSKQNK-QLKWYPLKRKTAPVALETENRGEMKLALQYVPEPSPGKKLPTTGEVHIWVK 2018

  Fly   634 KARNLKLDGEQPAPESAETVH-SVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIF-SVPPP 696
            :..:|.|         ....| :.|||..::....:..:::|....|..:|:||.:|:: ...|.
Mouse  2019 ECLDLPL---------LRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPE 2074

  Fly   697 SLTTTQLRVTVFGVTTSGVTPLGHIVAGSCAVGKGLRHWHQMLSSLRKPVAMWHVLRRAVNQP 759
            .|....:.:||:.........||.:..| ...||........:.|..:.||:|   .:.||.|
Mouse  2075 DLMEACVELTVWDHYKLTNQFLGGLRIG-FGTGKSYGTEVDWMDSTSEEVALW---EKMVNSP 2133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	31/108 (29%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	35/168 (21%)
Sytl2	NP_001355807.1	PHD_SF	5..>41	CDD:473978
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..98
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..289
		C2A_SLP-1_2	1848..1975	CDD:176039	39/143 (27%)
		C2B_SLP_1-2-3-4	1988..2144	CDD:175987	37/159 (23%)