Protein Alignment Syt12 and syt9a

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_001336058.4
• Gene: syt9a / 798433
• ZFINID: ZDB-GENE-031002-18
• Length: 547
• Species: Danio rerio
• Alignment Length: 606
• Identity: 152/606 - (25%)
• Similarity: 224/606 - (36%)
• Gaps: 203/606 - (33%)

  Fly   184 RQNGGTAGGAGGGGVLPQPLEAPPPPRLTASTSVNLSGTAIPRPIAKRQVSTQPANNSGCQPEQT 248
            |:.|.:.|...|.   |.|...||||                         .||      ||..|
Zfish    84 RERGLSPGTKEGH---PDPPHPPPPP-------------------------LQP------QPIYT 114

  Fly   249 VVTPMREGERKAPALKRRNSSTNPFLCESTEQIPSNPISE--PLNATVASLEKTTISTSECTPIT 311
            .|.         ..|.||:::.:..:.|:|  :|..|:|.  |.:.....:.:..:..|..:| .
Zfish   115 EVD---------ATLDRRSNARSSVVKETT--VPPTPVSPAVPGSPPAVPVPEAALKISHTSP-D 167

  Fly   312 APLETPNGPISTDTPSTIHHNGNPFVERESL--------SSRLLKIHNTTNPFTGLSQRVKGPHL 368
            .|||..    |....:.:|  ||..::|:..        .|.:.:..|.:||...::|
Zfish   168 IPLEVE----SKTQENGVH--GNTRMQRQITDPSSTCVRQSSIRRQMNQSNPDFTVTQ------- 219

  Fly   369 LQKTISEDYLFRKLGVNCPMANGNGTGPGSGHVNGNGNGTWSFGRSLLRQDSTLSLGMGLGRRNS 433
                                                          ..||||.  .||.||:...
Zfish   220 ----------------------------------------------FQRQDSL--TGMSLGQLKP 236

  Fly   434 ---SQVSLDSH--AGSVPGSMDGINLERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQ 493
               .|.|||..  ..|..||...::......||            |:|
Zfish   237 ELYKQRSLDGEDSRSSRVGSCGRLHFILKYDCD------------LEQ----------------- 272

  Fly   494 MSISNEGMELTVSVLEAKGLICPFSVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESFDFW 558
                     |.|.:..|:.|.......:.|.:|:|||:||.....||||.:.||.|.::|.|.|.
Zfish   273 ---------LIVKIHRAQDLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFP 328

  Fly   559 L-HKRQARHSLWFHLY--HNGPAHTLIGEAE----MEIGEMPRPITTWIPLSDSRKC-------- 608
            : :.......|.|.:|  .....|.:||:..    :::.:.||         :::.|
Zfish   329 VAYADLPTRKLHFSVYDFDRFSRHDIIGQVVVDNFLDLVDFPR---------ETKLCRDIQYVSS 384

  Fly   609 -NARWGELMFSLSYLPTAERLTIVVVKARNLKLDGEQPAPESAETVHSVFVKVYLMDKDRKVLKK 672
             |...|:|||||.|||||.||||.::||||||......|.:.       :|||.||...|::.|:
Zfish   385 DNVDLGDLMFSLCYLPTAGRLTITMIKARNLKAMDITGASDP-------YVKVSLMCDGRRLKKR 442

  Fly   673 RTSLKRKDRSPIFNESMIFSVPPPSLTTTQLRVTVFGVTTSGVTPLGH-IVAGSCAVGK-----G 731
            :||.||...:|::||:::|.|||.::....|.|.|.....     :|| .|.|.|.||.     |
Zfish   443 KTSTKRNTLNPVYNEAIVFDVPPENIDQISLLVAVMDYDR-----VGHNEVIGVCRVGNDAEGLG 502

  Fly   732 LRHWHQMLSSLRKPVAMWHVL 752
            ..||::||:..|||:|.||.|
Zfish   503 REHWNEMLTYPRKPIAHWHPL 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	29/105 (28%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	62/147 (42%)
syt9a	XP_001336058.4	C2	257..381	CDD:472691	34/170 (20%)
		C2B_Synaptotagmin-3-5-6-9-10	390..523	CDD:176048	61/144 (42%)