Protein Alignment Syt12 and Syt10

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_113854.1
• Gene: Syt10 / 60567
• RGDID: 62041
• Length: 523
• Species: Rattus norvegicus
• Alignment Length: 479
• Identity: 123/479 - (25%)
• Similarity: 201/479 - (41%)
• Gaps: 87/479 - (18%)

  Fly   295 ASLEKTTISTSECTPITAPLETPNGPISTDTPSTIHHNGNPFVERESLSSRLLKIHNTTNPFTGL 359
            :.|....:||...:..:||.|.    ..|:....:..|..|   ........:||.:|:......
  Rat    86 SKLVAPNVSTLPQSISSAPTEV----FETEEKKEVEENEKP---APKAIEPAIKISHTSPDIPAE 143

  Fly   360 SQRVKGPHLLQKTISEDYLFRKLGVNCPMANGNGTGPGSGHVNGNGNGTWSFGRSLLRQDSTLSL 424
            .|.....||::..               ......|.|.|...:.      ||.|.|.||.:..|:
  Rat   144 VQTALKEHLIKHA---------------RVQRQTTDPTSSSRHN------SFRRHLPRQMNVSSV 187

  Fly   425 GMGLG-----RRNSSQVSLDSHAGSVPGSMDGINLERAISCDSVTSDSTLFLDQLDQPYTQITGY 484
            ...:|     :|..::.|:    |.:...   :..::::..:....|.           .:..|.
  Rat   188 DFSMGTEPVLQRGETRTSI----GRIKPE---LYKQKSVDSEGNRKDD-----------VKTCGK 234

  Fly   485 LCVGLNYDQMSISNEGMELTVSVLEAKGLICPFSVESLDTFVRIYLVPDHPGAMQTKVVKGTLTP 549
            |...|.||.     |...|.|.:::|..|.......:.|.:|:|||:||.....||:|.:.||.|
  Rat   235 LNFALQYDY-----ENELLVVKIIKALDLPAKDFTGTSDPYVKIYLLPDRKKKFQTRVHRKTLNP 294

  Fly   550 SYNESFDF-WLHKRQARHSLWFHLY--HNGPAHTLIGEAEM----EIGEMPRPITTWIPLSDSRK 607
            .::|.|.| .::.:.:...|.|.:|  .....|.:|||..:    |:.::.|..|.|..:..:..
  Rat   295 LFDELFQFPVVYDQLSNRKLHFSIYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATT 359

  Fly   608 CNARWGELMFSLSYLPTAERLTIVVVKARNLK---LDGEQPAPESAETVHSVFVKVYLMDKDRKV 669
            .:...||:||||.|||||.|:|:.|:|.||||   :.|..          ..:|||.||.:.|::
  Rat   360 ESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSS----------DPYVKVSLMCEGRRL 414

  Fly   670 LKKRTSLKRKDRSPIFNESMIFSVPPPSLTTTQLRVTVFGVTTSGVTPLGH-IVAGSC-----AV 728
            .|::|:.|:...:|::||::||.:||.::....|.:.|.....     :|| .|.|.|     |.
  Rat   415 KKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCIAVMDYDR-----VGHNEVIGVCRTGLDAE 474

  Fly   729 GKGLRHWHQMLSSLRKPVAMWHVL 752
            |.|..||::||:..|||:..||.|
  Rat   475 GLGRDHWNEMLAYHRKPITHWHPL 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	31/105 (30%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	56/150 (37%)
Syt10	NP_113854.1	Cysteine motif. /evidence=ECO:0000250|UniProtKB:O35681	13..35
		C2A_Synaptotagmin-1-5-6-9-10	231..356	CDD:176031	37/129 (29%)
		C2B_Synaptotagmin-3-5-6-9-10	365..498	CDD:176048	55/147 (37%)