Protein Alignment Syt12 and Syt7

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001385543.1
• Gene: Syt7 / 59267
• RGDID: 62013
• Length: 687
• Species: Rattus norvegicus
• Alignment Length: 847
• Identity: 197/847 - (23%)
• Similarity: 317/847 - (37%)
• Gaps: 273/847 - (32%)

  Fly     1 MMSFTITLALLLLAVLILGILFACHCLGPRAANWMRMRSSKEEKIGLSNHKQKLFHANGYMASIQ 65
            ::|..||:: |.:.:::.|:   ||        |.:.:..|..|..|..           :.:..
  Rat    19 LVSAIITVS-LSVTIVLCGL---CH--------WCQRKLGKRYKNSLET-----------VGTPD 60

  Fly    66 SGSEFLLSTSGSFKRFDTIDKEDYNRSQQTHQTHL-------FLMN-------GGGAVSITGS-- 114
            ||     ...|..|..:.:|::.:|.::.|.|...       |::|       |...:|:.|:
  Rat    61 SG-----RGRGEKKAINDLDRDFWNNNESTVQQKWSSYPPKEFILNISPYAPYGDPRLSLNGTLL 120

  Fly   115 SSALQATTAMWHLPRSGIKIPPP---PDRPAPSPNSAAAAGKTVTFSLSQVNEVIMPGEQVTSND 176
            |.|..||.|      :|:.:...   .::|||.|                     .|||
  Rat   121 SGAKVATAA------AGLAVEREGRLGEKPAPVP---------------------PPGE------ 152

  Fly   177 QERRSCLRQNG------GTAGGAGGG--GVLPQPLEAPPPPRL--------TASTSVNLSGTAIP 225
                ..||..|      |::|.||.|  .::...|.|   .:|        |.||:..|.  :||
  Rat   153 ----DALRSGGAAPSEPGSSGKAGRGRWRMVQSHLAA---GKLNLSNFEDSTLSTATTLE--SIP 208

  Fly   226 RPIAKRQVSTQPANNSGCQPEQTVVTPMREGERKAPALKRRNSSTNPFLCESTEQIPSNPISEPL 290
                      ..|....||..:|              |.|:.|...|.......:.||.|
  Rat   209 ----------SSAGEPKCQRPRT--------------LMRQQSLQQPLSQNQRGRQPSQP----- 244

  Fly   291 NATVASLEKTTISTSECTPITAPLETPNGPISTDTPSTIHHNGNPFVERESLSSRLLKIHNTTNP 355
                        :||                                  :||..  |:.|..:.|
  Rat   245 ------------TTS----------------------------------QSLGQ--LQAHAASAP 261

  Fly   356 FTGLSQRVKGPHLLQKTISEDYLFRKLGVNCPMANGNGTGPGS-----GHVNGNGNGTWSF--GR 413
              |.:.|..|....::..|....:|..|      ..:.:.|||     |.:...|....||  ||
  Rat   262 --GSNPRAYGRGQARQGTSAGSKYRAAG------GRSRSNPGSWDHVVGQIRNRGLDMKSFLEGR 318

  Fly   414 SLLRQDSTLSLGMGL---------------GRRNSSQVSLDSH--AGS-------VPGSMDGINL 454
            .::     |||.:||               |.:.:.....|..  ||.       |||.......
  Rat   319 MVV-----LSLVLGLSEQDDFANIPDLQNPGTQQNQNAQGDKRLPAGGKAVNTAPVPGQTPHDES 378

  Fly   455 ERAISCDSVTSD--STLFLDQL--------DQPYTQITG------YLCVGLNYDQMSISNEGMEL 503
            :|.....|..||  ::|..:.|        |:.:...:.      ...||.|:.:.:       |
  Rat   379 DRRTEPRSSVSDLVNSLTSEMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQEST-------L 436

  Fly   504 TVSVLEAKGLICPFSVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESFDF--WLHKRQARH 566
            ||.|::|:.|.......:.|.||:|||:||....::|||.:..|.|.:||:|.|  :.:::..:.
  Rat   437 TVKVMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQR 501

  Fly   567 SLWFHL--YHNGPAHTLIGEAEMEIG--EMPRPITTWIPLSDSRKCNARWGELMFSLSYLPTAER 627
            .|:..:  |.....:..|||..:.:.  ::.:..|.|..|......:...|||:.||.|.|:|..
  Rat   502 ILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNPSANS 566

  Fly   628 LTIVVVKARNLK-LD-GEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMI 690
            :.:.::|||||| :| |....|         :|||:||.||::|.||:|..|:::.:||||||..
  Rat   567 IIVNIIKARNLKAMDIGGTSDP---------YVKVWLMYKDKRVEKKKTVTKKRNLNPIFNESFA 622

  Fly   691 FSVPPPSLTTTQLRVTVFG---VTTSGVTPLGHIVAGSCAVGKG-LRHWHQMLSSLRKPVAMWHV 751
            |.:|...|..|.:.:||..   ::.:.|  :|.|.. |...|.| ::||..|::..|:|||.||.
  Rat   623 FDIPTEKLRETTIIITVMDKDKLSRNDV--IGKIYL-SWKSGPGEVKHWKDMIARPRQPVAQWHQ 684

  Fly   752 LR 753
            |:
  Rat   685 LK 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	30/104 (29%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	56/146 (38%)
Syt7	NP_001385543.1	PHA03307	106..>311	CDD:223039	62/331 (19%)
		C2A_Synaptotagmin-7	419..543	CDD:176032	34/130 (26%)
		C2B_Synaptotagmin-7	551..686	CDD:176050	56/146 (38%)