Protein Alignment Syt12 and SYT13

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_065877.1
• Gene: SYT13 / 57586
• HGNCID: 14962
• Length: 426
• Species: Homo sapiens
• Alignment Length: 336
• Identity: 94/336 - (27%)
• Similarity: 142/336 - (42%)
• Gaps: 88/336 - (26%)

  Fly   449 MDGINLERAIS---------C-DSVTSDSTLFLDQLDQPYTQITGYLCVGLN-YDQMSISNEGME 502
            |:..|.|:|.|         | |.....:.||:.:|:...:...|    |.: |.|.|::|.
Human   145 METWNPEKAASWNQAPKLHYCLDYDCQKAELFVTRLEAVTSNHDG----GCDCYVQGSVANR--- 202

  Fly   503 LTVSVLEA--------------KGLICPFSVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNE 553
             |.|| ||              :||:.|.:.|.|.|                    .|||.:...
Human   203 -TGSV-EAQTALKKRQLHTTWEEGLVLPLAEEELPT--------------------ATLTLTLRT 245

  Fly   554 SFDFWLHKRQARHSLWFHLYHNGPAHTLIGEAEMEIG----EMPRPITTWIPLSDSRK-CNARWG 613
            .      .|.:|||:               ..|:.:|    .:|.....|..|..|.| .:|..|
Human   246 C------DRFSRHSV---------------AGELRLGLDGTSVPLGAAQWGELKTSAKEPSAGAG 289

  Fly   614 ELMFSLSYLPTAERLTIVVVKARNLKLDGEQPAPESAETV-HSVFVKVYLMDKDRKVLKKRTSLK 677
            |::.|:||||.|.||.:|::||:||.      :.:|.|.: ..|.|||.|..:.||:.||:|...
Human   290 EVLLSISYLPAANRLLVVLIKAKNLH------SNQSKELLGKDVSVKVTLKHQARKLKKKQTKRA 348

  Fly   678 RKDRSPIFNESMIFSVPPPSLTTTQLRVTVFGVTTSGVT-PLGHIVAGSCAVGKGLRHWHQMLSS 741
            :...:|::||.::|.:|...|..:.:.:.|.|...||.: .|||...|....|....||.:||.:
Human   349 KHKINPVWNEMIMFELPDDLLQASSVELEVLGQDDSGQSCALGHCSLGLHTSGSERSHWEEMLKN 413

  Fly   742 LRKPVAMWHVL 752
            .|:.:||||.|
Human   414 PRRQIAMWHQL 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	22/116 (19%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	52/143 (36%)
SYT13	NP_065877.1	C2A_Synaptotagmin-13	160..277	CDD:176059	33/166 (20%)
		C2B_Synaptotagmin-13	288..425	CDD:176052	52/143 (36%)