Protein Alignment Syt12 and syt10

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_017210538.3
• Gene: syt10 / 564226
• ZFINID: ZDB-GENE-041210-297
• Length: 566
• Species: Danio rerio
• Alignment Length: 571
• Identity: 141/571 - (24%)
• Similarity: 222/571 - (38%)
• Gaps: 155/571 - (27%)

  Fly   197 GVLPQPLEAPP-PPRLTASTSVNLSGTAIPRPIAKRQVSTQPANNSGCQPEQTVVTPMREGERKA 260
            |||   ||||| ||.::.|.|          |.|:    .:....:|.||.|.......:.:.|.
Zfish   111 GVL---LEAPPAPPPVSRSVS----------PYAE----AKAVGVAGRQPSQIQHEDEEDKKWKV 158

  Fly   261 PALKRRNSSTNPFLCESTEQIPSNPISEPLNATVASLEKTTISTSECTPITAPLETPNGPISTDT 325
            |.:|....|:...|                        :..:..|:.:|              |.
Zfish   159 PEVKVNGRSSVKIL------------------------EAAMKISQTSP--------------DI 185

  Fly   326 PSTIHHNGNPFVERESLSSRLLKIHNTTNPFTGLSQRVKGPHLLQK--TISEDYLFRKLGVNCPM 388
            |:.:..     ..|:.||.:......||.|.:.........||.::  ..|.|:....|.|
Zfish   186 PAEVQQ-----ALRDRLSKQAKIQRQTTEPTSSSRHNSFRRHLPRQMNVTSVDFTMDTLPV---- 241

  Fly   389 ANGNGTGPGSGHVNGNGNGTWSFGRSLLRQDSTLSLGMGLGRRNSSQVSLDSHAGSVPGSMDGIN 453
                                        ||.|.:|:|. :......|.|:||..|:
Zfish   242 ----------------------------RQSSAVSIGR-IKPELYKQKSVDSEEGT--------- 268

  Fly   454 LERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVLEAKGLICPFS 518
                                 .:| .:..|.|...|:||.     |...|.|.:|:|..|.....
Zfish   269 ---------------------KEP-VETCGKLSFALSYDY-----EEQALVVRILKALDLPAKDF 306

  Fly   519 VESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESFDFWL-HKRQARHSLWFHLY--HNGPAHT 580
            ..:.|.:|:|||:|:.....||:|.:.||.|:::|.|.|.: :.......|.|.:|  ....:|.
Zfish   307 TGTSDPYVKIYLLPERKKKFQTRVHRKTLNPTFDEDFRFPVEYSELCNRKLHFSVYDFDRFTSHD 371

  Fly   581 LIGEAEM----EIGEMPRPITTWIPLSDSRKCNARWGELMFSLSYLPTAERLTIVVVKARNLK-- 639
            :|||..:    |:.::.|....|..:..:...:...||:|:||.|||||.|:|:.|:|.||||
Zfish   372 MIGEVVVDNLFELSDLSREAVVWKDILAATTESVDLGEIMYSLCYLPTAGRMTLTVIKCRNLKAM 436

  Fly   640 -LDG-EQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIFSVPPPSLTTTQ 702
             :.| ..|           :|||.|:...|::.|::|:.|:...:|::||::||.:||.::....
Zfish   437 DITGYSDP-----------YVKVALICDGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVEQVS 490

  Fly   703 LRVTVFGVTTSGVTP-LGHIVAGSCAVGKGLRHWHQMLSSLRKPVAMWHVL 752
            |.:||......|... :|...||..|.|.|..||::||:..|||:..||.|
Zfish   491 LSITVMDYDRVGHNEVIGVCRAGPDAEGLGRDHWNEMLAYPRKPITHWHAL 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	30/105 (29%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	55/146 (38%)
syt10	XP_017210538.3	C2A_Synaptotagmin-1-5-6-9-10	274..399	CDD:176031	36/129 (28%)
		C2B_Synaptotagmin-3-5-6-9-10	408..541	CDD:176048	54/143 (38%)