Protein Alignment Syt12 and syt7a

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_021326273.2
• Gene: syt7a / 561429
• ZFINID: ZDB-GENE-090601-5
• Length: 653
• Species: Danio rerio
• Alignment Length: 820
• Identity: 193/820 - (23%)
• Similarity: 302/820 - (36%)
• Gaps: 249/820 - (30%)

  Fly     3 SFTITLALLLLAVLILGILFACHCLGPRAANWMRMRSSKEEKIGLSNHKQKLFHANGYMASIQSG 67
            |.::::.|:.|||.:.|:.....|   ....|.:.:..|..|.|:.:           :.|..||
Zfish    13 SISLSVLLVSLAVTVCGVWLVALC---GVCGWCQRKLGKRNKPGVES-----------VGSPDSG 63

  Fly    68 SEFLLSTSGSFKRFDTIDKEDYNRSQQTHQTHLFLMNGGGAVSITGSSSALQATTAMWHLPRSGI 132
                 ...|..|..:.:|::.:|.:                     .||::|...:.:......:
Zfish    64 -----RGRGEKKAINDLDRDFWNNN---------------------DSSSVQQRWSSYPPKEFVL 102

  Fly   133 KIPPPPDRPAPSPNSAAAAGKTVTFSLSQVNEVIMPGEQVTSNDQERRSCLRQNGGTAG---GAG 194
            .|.|    .||..:.......||            ||.|               .|.||   |.|
Zfish   103 NISP----YAPYGDPRLTLNGTV------------PGGQ---------------KGAAGCVLGDG 136

  Fly   195 GGGVLPQPLEAPPPPRLTASTSVNLSGTAIPRPIAKRQVSTQPANNSGCQPEQTVVTPMREGERK 259
            ||           |.|..:..|:...|....|                   .|||.:.:..|:.|
Zfish   137 GG-----------PSRSDSVRSMMTGGIKAGR-------------------WQTVQSRLHSGDFK 171

  Fly   260 APALKRRNSSTNPFLCESTEQIPS-------------NPISEPLNATVASLEKTTISTSECTPIT 311
            ...|.....|:    .|:.:.:||             ..:.:||                   |.
Zfish   172 NGNLSDHTLSS----VETLDYVPSAGATPRPRTLLRQQSLQQPL-------------------IQ 213

  Fly   312 APLETPNGPISTDTPSTIHHNGNPFVERESLSSRLLKIHNTTNPFTGLSQRVKGPHLLQKTISED 376
            ||  .||                 ...|..:|..|.::|  |.| .|......|....:.:..|.
Zfish   214 AP--PPN-----------------LASRPPISQSLGQLH--TQP-GGAGPGGGGGAGSRNSRGEP 256

  Fly   377 YLFRKLGVNCPMANGNGTG-PGS-----GHVNGNGNGTWSF--GRSLLRQDSTLSLGMGLGR--- 430
            ...|..|     |.|.|:| |||     |.:...|....||  |:.::     |||.:||..
Zfish   257 AQHRSAG-----AGGRGSGNPGSVDHMMGQIKKRGLDVKSFLEGKMVV-----LSLAIGLAEQDD 311

  Fly   431 --------------------RNSSQVSLDSHAGSVPGSMDGINLERAIS--CDSVTSDSTLFL-- 471
                                ||......:|..|..|.: ||   ..::|  .:|:|.|..:..
Zfish   312 FANLPDLQEVPASQETPEKSRNMGNKPANSPKGQPPDA-DG---HSSVSDLANSLTGDMVMLSPG 372

  Fly   472 ---DQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVLEAKGLICPFSVESLDTFVRIYLVPD 533
               |..:.|.::..|.:...|.|     |.:...|||.:|:.:.|.......:.|.||:|||:||
Zfish   373 SEDDDHEGPVSEKLGRIQFSLGY-----SFQDTTLTVKILKGQDLPAKDFSGTSDPFVKIYLLPD 432

  Fly   534 HPGAMQTKVVKGTLTPSYNESFDF--WLHKRQARHSLWFHL--YHNGPAHTLIGEA-----EMEI 589
            ....::|||.:..|.|.:||:|.|  :.:::....:|:..:  |.....:..|||.     ::|:
Zfish   433 RKHKLETKVKRKNLNPHWNETFLFEGFPYEKVRERTLYLQVLDYDRFSRNDPIGEVSIPLNKVEL 497

  Fly   590 GEMPRPITTWIPLSDSRKCNARWGELMFSLSYLPTAERLTIVVVKARNLK-LD-GEQPAPESAET 652
            |::.   :.|..|......:...|:|:.||.|.|||..:|:.::|||||| :| |....|
Zfish   498 GQLK---SFWKDLKPCSDGSGSRGDLLVSLCYNPTANTITVNIIKARNLKAMDIGGTSDP----- 554

  Fly   653 VHSVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIFSVPPPSLTTTQLRVTVFG---VTTSG 714
                :|||:||.||::|.||:|...::..:|:||||..|.||...|..|.:.:||..   ::.:.
Zfish   555 ----YVKVWLMHKDKRVEKKKTVTIKRCLNPVFNESFPFDVPAHVLRETTIIITVMDKDRLSRND 615

  Fly   715 VTPLGHIVAGSCAVGKG-LRHWHQMLSSLRKPVAMWHVLR 753
            |  :|.|.. |...|.| ::||..|||..|..||.||.|:
Zfish   616 V--IGKIYL-SWKSGPGEVKHWKDMLSRPRTNVAQWHALK 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	30/107 (28%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	57/146 (39%)
syt7a	XP_021326273.2	None