Protein Alignment Syt12 and Syt8

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_006508695.1
• Gene: Syt8 / 55925
• MGIID: 1859867
• Length: 402
• Species: Mus musculus
• Alignment Length: 459
• Identity: 120/459 - (26%)
• Similarity: 185/459 - (40%)
• Gaps: 129/459 - (28%)

  Fly   343 SSRLLKIHNTTNPFTGLS--QRVKGPHLLQKTISEDYLFRKLGVNCPMANGNGTGPGSGHVNGNG 405
            :.|.:|:.:..|||:..:  ....||.|:...|:          ..|.|...|.||
Mouse     3 ADRSMKMGHALNPFSTSAPLDATAGPSLIPDLIT----------RIPSACAPGLGP--------- 48

  Fly   406 NGTWSFGRSLL---------------------------RQDSTLSLGMGLGRRNSSQVSLDSHAG 443
              .|:...::|                           :...|:.||   ..|||:...|
Mouse    49 --RWTLFIAILAAGVLLVSCLLCVICCYCHRHRHRKQPKDKETVGLG---SARNSTTTHL----- 103

  Fly   444 SVPGSMDGINLERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSV- 507
                      ::..:.|....|..       ||.:    |.|.:.|.||..|     .|:.|.:
Mouse   104 ----------VQPDVDCLEPCSGG-------DQQW----GRLLLSLEYDFGS-----QEIRVGLR 142

  Fly   508 ----LEAKGLICPFSVESLDTFVRIYLVPDHPGAM-QTKVVKGTLTPSYNESFDFW-----LHKR 562
                |:|:|...|::..|:.|         ..|.. :|||.:|||:|.:.|:..|.     |.|.
Mouse   143 QAGNLKAEGTADPYAWVSVST---------QSGRRHETKVHRGTLSPMFEETCCFLVPPAELPKA 198

  Fly   563 QARHSLW-FHLYHNGPAHTLIGEAEMEIG--EMPRPITTWIPLSDSRKCN-ARWGELMFSLSYLP 623
            ..:..|| |..:..   |..:||.::.:|  ::...:.:|..|....... .:.|||.|||.|:|
Mouse   199 TLKVQLWDFKRFSE---HEPLGELQLPLGTVDLQHVLESWYQLGPPGTTEPEQMGELCFSLRYVP 260

  Fly   624 TAERLTIVVVKARNLKLDGEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNES 688
            ::..||:||::||.|.       |..||    .:||:.||...||..|.:||.|:...:|.|||:
Mouse   261 SSGSLTVVVLEARGLN-------PGLAE----AYVKIQLMLNQRKWKKSKTSSKKGTTTPYFNEA 314

  Fly   689 MIFSVPPPSLTTTQLRVTVFGVTTSGV----TPLGHIVAGSCAVGKGLRHWHQMLSSLRKPVAMW 749
            .:|.||...|.:..|   |..|...|:    .|:|.::.||.|.|:.|:||..||:..|:|:|.|
Mouse   315 FVFLVPVSQLQSVDL---VLAVWARGLQLRTEPVGKVLLGSRASGQPLQHWADMLAHARRPIAQW 376

  Fly   750 HVLR 753
            |.||
Mouse   377 HHLR 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	27/112 (24%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	56/144 (39%)
Syt8	XP_006508695.1	C2	122..240	CDD:472691	35/134 (26%)
		C2	249..379	CDD:472691	56/143 (39%)