Protein Alignment Syt12 and sytl5

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_686619.6
• Gene: sytl5 / 558324
• ZFINID: ZDB-GENE-070912-424
• Length: 692
• Species: Danio rerio
• Alignment Length: 635
• Identity: 140/635 - (22%)
• Similarity: 235/635 - (37%)
• Gaps: 163/635 - (25%)

  Fly   198 VLPQPLEAPPPPRLTASTSVNLSGTAIPRPIAKRQVSTQPANNSGCQPEQTVVTPMREGERKAPA 262
            |:.|.:.:.||...:|:..:.:..::.|:  ::|.|:.|...::|         ..|:|:| |.|
Zfish   139 VVKQSILSSPPDGGSANRPLEMERSSTPK--SERSVTPQSQKSTG---------KNRKGKR-AVA 191

  Fly   263 LKRRNSSTNPFLCESTEQIPSNPI-SEPLNATVASLEKTTISTSECTPITAPLETPNGPISTD-- 324
            ::.....|.|  .....|:...|. :|..|....:...::|.:|:    :.|.:..:|...||
Zfish   192 VEPSGLPTVP--NNMRAQMAKTPTQTEARNRPDGAESVSSIQSSD----SVPEKMADGRRQTDSS 250

  Fly   325 TPSTIHHNGNPFVERESLSS-RLLKIHNTTNPFTGLSQRVKGPHLLQKTISEDYLFRKLGVNCPM 388
            |||..       |.|.|||| |.....:.:||..||              |||.|..:    |..
Zfish   251 TPSIA-------VSRASLSSDRSRSEVDLSNPGEGL--------------SEDPLISR----CRS 290

  Fly   389 ANGNGTGPGSGHVNGNGNGTWSFGRSLLRQDSTLSLGMGLGRRNSSQVSLDSHAGS--------V 445
            ..|...|.....:                 |:.||......|...|..|:.|...|        |
Zfish   291 VPGLNDGDSDEDI-----------------DAVLSAHYKTNRSVCSAQSMSSTPASERKWGFLNV 338

  Fly   446 PGSMDGINLERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVLEA 510
            |.|        .....|:.|..:::.:..|....:::|.:.:.::|     |.:...|.|.|.|.
Zfish   339 PDS--------DADTTSINSLMSVYSETGDYGSVRVSGEILLNISY-----SYKTGALNVLVREC 390

  Fly   511 KGLIC-PFSVESLDTFVRIYLVPD--HPGAMQTKVVKGTLTPSYNESFDF-----WLHKRQARHS 567
            :.|.. ....:..|.:|:.||:||  .....:|.:...:..|.:||:..:     .|..|..:.|
Zfish   391 RCLATGDERRQRTDAYVKTYLLPDKSRQSKRKTSIKSNSTNPVFNENLRYVVSHSQLETRTLQVS 455

  Fly   568 LWFH--LYHNGPAHTLIGEAEM--EIGEMPRPITTWIPL-----SDSRKCNARW-GELMFSLSYL 622
            :|.|  ..||    ..:||.|:  :..|....|..|..|     ||.......: |||...|.|:
Zfish   456 VWHHDRFGHN----NFLGETELTFDSWEFDTQIEEWFALQPRIESDYVDSVMHYKGELTVVLKYI 516

  Fly   623 PTAER------------------------------LTIVVVKARNL-KLDGEQPAPESAETVHSV 656
            | |||                              :.::|.:|:|| .:.|....|
Zfish   517 P-AERNVSLPLDQVQVKKGFLKGKKKTITLPKGGMVELLVKEAKNLTAVKGGSSDP--------- 571

  Fly   657 FVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIF-SVPPPSLTTTQLRVTVF------------ 708
            |||.||:..|:|..|.:|::.::..:|.:|.:..: .:....|.:..|.:||:
Zfish   572 FVKGYLLPDDKKSTKHKTAVVKRSVNPRWNHTFTYCGLQHSDLDSVCLELTVWDREPFASNVFLG 636

  Fly   709 GVTTSGVTPL--GHIVAGSCAVGKGLRHWHQMLSSLRKPVAMWHVLRRAV 756
            ||.....|.|  |..|..:.|.|:..|.|.:|:.:...|.....:||.::
Zfish   637 GVRLGAGTGLSYGKEVDWNDAYGEEQRLWQRMIDNPEVPQECTLMLRSSM 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	28/110 (25%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	42/187 (22%)
sytl5	XP_686619.6	PHD_SF	13..124	CDD:473978
		PHA03247	<132..401	CDD:223021	70/334 (21%)
		C2A_SLP-4_5	367..491	CDD:175995	31/132 (23%)
		C2B_SLP_1-2-3-4	506..683	CDD:175987	42/186 (23%)