Protein Alignment Syt12 and Syt7

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_030106854.1
• Gene: Syt7 / 54525
• MGIID: 1859545
• Length: 719
• Species: Mus musculus
• Alignment Length: 847
• Identity: 197/847 - (23%)
• Similarity: 317/847 - (37%)
• Gaps: 273/847 - (32%)

  Fly     1 MMSFTITLALLLLAVLILGILFACHCLGPRAANWMRMRSSKEEKIGLSNHKQKLFHANGYMASIQ 65
            ::|..||:: |.:.:::.|:   ||        |.:.:..|..|..|..           :.:..
Mouse    51 LVSAIITVS-LSVTIVLCGL---CH--------WCQRKLGKRYKNSLET-----------VGTPD 92

  Fly    66 SGSEFLLSTSGSFKRFDTIDKEDYNRSQQTHQTHL-------FLMN-------GGGAVSITGS-- 114
            ||     ...|..|..:.:|::.:|.::.|.|...       |::|       |...:|:.|:
Mouse    93 SG-----RGRGEKKAINDLDRDFWNNNESTVQQKWSSYPPKEFILNISPYAPYGDPRLSLNGTLL 152

  Fly   115 SSALQATTAMWHLPRSGIKIPPP---PDRPAPSPNSAAAAGKTVTFSLSQVNEVIMPGEQVTSND 176
            |.|..||.|      :|:.:...   .::|||.|                     .|||
Mouse   153 SGAKVATAA------AGLAVEREGRLGEKPAPVP---------------------PPGE------ 184

  Fly   177 QERRSCLRQNG------GTAGGAGGG--GVLPQPLEAPPPPRL--------TASTSVNLSGTAIP 225
                ..||..|      |::|.||.|  .::...|.|   .:|        |.||:..|.  :||
Mouse   185 ----DALRSGGAAPSEPGSSGKAGRGRWRMVQSHLAA---GKLNLSNFEDSTLSTATTLE--SIP 240

  Fly   226 RPIAKRQVSTQPANNSGCQPEQTVVTPMREGERKAPALKRRNSSTNPFLCESTEQIPSNPISEPL 290
                      ..|....||..:|              |.|:.|...|.......:.||.|
Mouse   241 ----------SSAGEPKCQRPRT--------------LMRQQSLQQPLSQNQQGRQPSQP----- 276

  Fly   291 NATVASLEKTTISTSECTPITAPLETPNGPISTDTPSTIHHNGNPFVERESLSSRLLKIHNTTNP 355
                        :||                                  :||..  |:.|..:.|
Mouse   277 ------------TTS----------------------------------QSLGQ--LQAHAASAP 293

  Fly   356 FTGLSQRVKGPHLLQKTISEDYLFRKLGVNCPMANGNGTGPGS-----GHVNGNGNGTWSF--GR 413
              |.:.|..|....::..|....:|..|      ..:.:.|||     |.:...|....||  ||
Mouse   294 --GSNPRAYGRGQARQGTSAGSKYRAAG------GRSRSNPGSWDHVVGQIRNRGLDMKSFLEGR 350

  Fly   414 SLLRQDSTLSLGMGL---------------GRRNSSQVSLDSH--AGS-------VPGSMDGINL 454
            .::     |||.:||               |.:.:.....|..  ||.       |||.......
Mouse   351 MVV-----LSLVLGLSEQDDFANIPDLQNPGTQQNQNAQGDKRLPAGGKAVNTAPVPGQTPHDES 410

  Fly   455 ERAISCDSVTSD--STLFLDQL--------DQPYTQITG------YLCVGLNYDQMSISNEGMEL 503
            :|.....|..||  ::|..:.|        |:.:...:.      ...||.|:.:.:       |
Mouse   411 DRRTETRSSVSDLVNSLTSEMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQEST-------L 468

  Fly   504 TVSVLEAKGLICPFSVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESFDF--WLHKRQARH 566
            ||.|::|:.|.......:.|.||:|||:||....::|||.:..|.|.:||:|.|  :.:::..:.
Mouse   469 TVKVMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQR 533

  Fly   567 SLWFHL--YHNGPAHTLIGEAEMEIG--EMPRPITTWIPLSDSRKCNARWGELMFSLSYLPTAER 627
            .|:..:  |.....:..|||..:.:.  ::.:..|.|..|......:...|||:.||.|.|:|..
Mouse   534 VLYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNPSANS 598

  Fly   628 LTIVVVKARNLK-LD-GEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMI 690
            :.:.::|||||| :| |....|         :|||:||.||::|.||:|..|:::.:||||||..
Mouse   599 IIVNIIKARNLKAMDIGGTSDP---------YVKVWLMYKDKRVEKKKTVTKKRNLNPIFNESFA 654

  Fly   691 FSVPPPSLTTTQLRVTVFG---VTTSGVTPLGHIVAGSCAVGKG-LRHWHQMLSSLRKPVAMWHV 751
            |.:|...|..|.:.:||..   ::.:.|  :|.|.. |...|.| ::||..|::..|:|||.||.
Mouse   655 FDIPTEKLRETTIIITVMDKDKLSRNDV--IGKIYL-SWKSGPGEVKHWKDMIARPRQPVAQWHQ 716

  Fly   752 LR 753
            |:
Mouse   717 LK 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	30/104 (29%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	56/146 (38%)
Syt7	XP_030106854.1	C2A_Synaptotagmin-7	451..575	CDD:176032	34/130 (26%)
		C2B_Synaptotagmin-7	583..718	CDD:176050	56/146 (38%)