Protein Alignment Syt12 and Syt6

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001415742.1
• Gene: Syt6 / 54524
• MGIID: 1859544
• Length: 529
• Species: Mus musculus
• Alignment Length: 569
• Identity: 152/569 - (26%)
• Similarity: 231/569 - (40%)
• Gaps: 132/569 - (23%)

  Fly   238 ANNSGCQPEQTVVTPMREGERKAPALKRRNSSTNPFLCESTEQIPS---NPISEPLNATVASL-- 297
            |....||....|:..:...  :.|.|.....:...|..:|.||.||   :..|..|.|.|..:
Mouse     7 AGGPRCQAALAVLASLCRA--RPPPLGLDVETCRSFELQSPEQSPSAADSGTSVSLLAVVVIVCG 69

  Fly   298 --------------------EKTTISTSECTPITAPLETP----NGPISTDTPSTIHHNGNPFVE 338
                                :|...|.|...|.:..|::|    |.......||.:     .|:|
Mouse    70 VALVAVFLFLFWKLCWMPWRKKEASSPSSANPASETLQSPSSRGNMADKLKDPSAL-----GFLE 129

  Fly   339 RESLSSRLLKIHNTTNPFTGLSQRVKGPHLLQKTISEDYLFRKLGVNCPMANGNGTGPGSG--HV 401
                  ..:||.:|:.......|.....|:::.|        ||       ....|.|.|.  |.
Mouse   130 ------AAVKISHTSPDIPAEVQMSVKEHIMRHT--------KL-------QRQTTEPASSTRHT 173

  Fly   402 NGNGNGTWSFGRSLLRQDSTLSLGMGLGRRNSSQVSLDSHAGSVPGSMDGINLE----RAISCDS 462
                    ||.|.|.||....|:..|        ..|...|...|.|:..|..|    :::..|.
Mouse   174 --------SFKRHLPRQMHVSSVDYG--------NELPPAAAEQPTSIGRIKPELYKQKSVDGDD 222

  Fly   463 VTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVLEAKGLICPFSVESLDTFVR 527
            ..|::           .:..|.:...|.||.     |...|.|.:|:|..|.......|.|.:|:
Mouse   223 AKSEA-----------AKSCGKINFSLRYDY-----ESETLIVRILKAFDLPAKDFCGSSDPYVK 271

  Fly   528 IYLVPDHPGAMQTKVVKGTLTPSYNESFDFWL-HKRQARHSLWFHL----YHNGPAHTLIGEAEM 587
            |||:||....:||:|.:.||.|:::|:|.|.: ::..|...|  ||    :.....|.:|||..:
Mouse   272 IYLLPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKL--HLSVFDFDRFSRHDMIGEVIL 334

  Fly   588 ----EIGEMPRPITTWIPLSDSRKCNARWGELMFSLSYLPTAERLTIVVVKARNLK---LDG-EQ 644
                |..::.|..:.|..:..:...:...||:||||.|||||.|||:.|:|.||||   :.| ..
Mouse   335 DNLFEASDLSRETSIWKDIQYATSESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSD 399

  Fly   645 PAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIFSVPPPSLTTTQLRVTVFG 709
            |           :|||.|:...|::.||:|::|:...:||:||::||.:||.::....|.::|..
Mouse   400 P-----------YVKVSLLCDGRRLKKKKTTIKKNTLNPIYNEAIIFDIPPENMDQVSLLISVMD 453

  Fly   710 VTTSGVTPLGH-IVAGSCAV-----GKGLRHWHQMLSSLRKPVAMWHVL 752
            ...     :|| .:.|.|.|     |.|..||::||:..|||:|.||.|
Mouse   454 YDR-----VGHNEIIGVCRVGINAEGLGRDHWNEMLAYPRKPIAHWHSL 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	33/107 (31%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	59/151 (39%)
Syt6	NP_001415742.1	Cysteine motif. /evidence=ECO:0000250|UniProtKB:O35681	12..38		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	92..119		6/26 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..182		11/47 (23%)
		C2A_Synaptotagmin-1-5-6-9-10	231..355	CDD:176031	38/130 (29%)
		C2B_Synaptotagmin-3-5-6-9-10	364..497	CDD:176048	58/148 (39%)