Protein Alignment Syt12 and Sytl3

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_006227950.1
• Gene: Sytl3 / 499017
• RGDID: 1561992
• Length: 609
• Species: Rattus norvegicus
• Alignment Length: 587
• Identity: 128/587 - (21%)
• Similarity: 209/587 - (35%)
• Gaps: 212/587 - (36%)

  Fly   255 EGERKAPALKRRNSSTNPFLCESTEQIPSNPISEPLNATVASLEKTTISTSECTPITAPLETPNG 319
            |..||.|...||.::....|  .:.|..|:.||      |.......:|.|:|
  Rat   123 ERARKFPTAGRRETAGARLL--QSYQRQSSKIS------VVPPTPPPLSESQC------------ 167

  Fly   320 PISTDTPSTI----HHNG-NPFVER--ESLSSRLLKIHNTTNPFTGLSQRVKGPHLL-------- 369
               ..:|:.:    |..| |..||.  .|:::::.|:..:.|..|  |::    |||
  Rat   168 ---GGSPNRLQELGHFRGFNKSVENLFLSVTTQMRKLSKSQNDMT--SEK----HLLAMDPRQCM 223

  Fly   370 -----------------QKTISEDYL--FRKLGVNCPMANGNGTGPGSGHVNGNGNGTWSFGRSL 415
                             :||.:.|.|  |.:.....|.:                        .:
  Rat   224 GHTERRSQSDTAVNVTSRKTSTPDILKAFHQEDPRHPPS------------------------PV 264

  Fly   416 LRQD--------STLSLGMGLGRRNSSQVSLDSHAGSVPGSMDGINLERAISCDSVTSDSTLFLD 472
            |:||        ||:..|   |.|:.|.:|::|....: |:.|..|
  Rat   265 LKQDTPPSSPTHSTVFSG---GLRHGSLISVNSTCTEM-GNFDNAN------------------- 306

  Fly   473 QLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVL------EAKGLICPFSVESLDTFVRIYLV 531
                    :||.:...::|   .:::..:|:.:...      |.|...|       :.:|:.||:
  Rat   307 --------VTGEIEFAIHY---CVNSHSLEICIKTCKNLAYGEDKRRKC-------NPYVKTYLL 353

  Fly   532 PDH--PGAMQTKVVKGTLTPSYNESFDFWLHKRQ-ARHSLWFHLYHNGPAHTLIGEAEMEIGEMP 593
            ||.  .|..:|:|.|.||.|::.|:..:.:...| |...|...::|.|   ||  ...:.:||:.
  Rat   354 PDRSSQGKRKTRVQKNTLDPTFEETLKYQVDPAQLATRRLQVSVWHLG---TL--ARRVFLGEVI 413

  Fly   594 RPITTWIPLSDSRKCNARW------------------GELMFSLS-YLPTAER------------ 627
            .|:.|| ....|...||||                  |||..... .||...|
  Rat   414 LPLATW-DFEGSAAQNARWYPLRAKAEKYEENIPQTNGELAVRAKLVLPVGPRMLQEAQEDQLAL 477

  Fly   628 ---LTIVVVKARNL--KLDGEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNE 687
               |.:||:.|:||  :.||         |::| |||..|...|::.|:.::.:.:|...|.:..
  Rat   478 NGQLCLVVLGAKNLPVRSDG---------TLNS-FVKGCLTLPDQQKLRVKSPVLKKQACPQWKH 532

  Fly   688 SMIFS-VPPPSLTTTQLRVTVFGVTTSGVTP--LGHIVAG----------SCAVGKGLRHWHQML 739
            |.:|: |....|..:.|.:||:.....|:..  ||....|          ||:..|  ..|.::|
  Rat   533 SFVFNGVSSSQLRQSTLELTVWDQAMFGMNDRLLGEAKLGSKGGAPGCTDSCSQSK--LQWQKVL 595

  Fly   740 SS 741
            ||
  Rat   596 SS 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	28/107 (26%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	43/179 (24%)
Sytl3	XP_006227950.1	PHD_SF	14..123	CDD:473978	128/587 (22%)
		FYVE_like_SF	60..108	CDD:333710
		C2	308..435	CDD:472691	37/142 (26%)
		C2B_SLP_1-2-3-4	449..609	CDD:175987	42/161 (26%)