Protein Alignment Syt12 and sytl2

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_012812257.2
• Gene: sytl2 / 493264
• XenbaseID: XB-GENE-945155
• Length: 2036
• Species: Xenopus tropicalis
• Alignment Length: 724
• Identity: 145/724 - (20%)
• Similarity: 239/724 - (33%)
• Gaps: 224/724 - (30%)

  Fly    38 RSSKEEKIGLSNHKQKLFHANGYM---ASIQSGSEFL--LSTSGSFKRFDTID---KEDYNRSQQ 94
            |||||              .:||.   |.:::.....  ||.:.|.|...|::   :.|.|..:.
 Frog  1382 RSSKE--------------LDGYSKLNAQLKTKDNLKDNLSDTSSTKTASTLNDLQERDENVYKD 1432

  Fly    95 THQTHLFLMNGGGAV---SITGSSSA------------LQATTAMWHLPRSGIKIPPPPDRP--- 141
            ........::|..|.   .|.|..:|            :.|....|..|.|       .|.|
 Frog  1433 ISSRESSSVDGASAAVIGDIIGKDAASLDLHQHTDEEEIGAREWNWEEPES-------QDNPTFI 1490

  Fly   142 APSPNSAAAAGKTVTFSLSQVNEVIMPGEQVTSNDQERRSCLRQNGGTAGGAGGGGVLPQPLEAP 206
            :..|:......|.|..::..     :|..:...|:.:|.:..::.|.|
 Frog  1491 SNMPSRDVVISKKVYSTIES-----LPSYKDKENNLDRLTEPQEQGST----------------- 1533

  Fly   207 PPPRLTASTSVNLSGTAIPRPIAKRQVSTQPANNSGCQPEQTVVTPMREGERKAPALKRRNS--- 268
                 |.....:|...|....:.|...|.|    ||...|.:.....::.|.::|...:|||
 Frog  1534 -----TQRKPQDLYFAARYEVLDKNSGSDQ----SGSVTESSGNLLYKKPESESPDASKRNSIDP 1589

  Fly   269 -----STNPFL----CESTEQIPSNPISEPLNATVASLEKTTISTSECTPITAPLETPNGPISTD 324
                 .::|.|    ..||:.:|..|:.|      .||||     |....||.|.|..:......
 Frog  1590 KQGIEESDPILRALKRSSTKTLPPLPVQE------VSLEK-----SNQDDITVPKEDRDHTYEEV 1643

  Fly   325 TPSTIHHNGNPFVERESLSSRLLKIHNTTNPFTGLSQRVKGPHLLQKTISEDYLFRKLGVNCPMA 389
            ....:....:.|.:.|.|..              |||.|  |..|    ::|            .
 Frog  1644 RADKVVPERSHFSDPEKLKR--------------LSQSV--PSFL----NDD------------T 1676

  Fly   390 NGNGTGPGSGHVNGNGNGTWSFGRSLLRQDSTLSLGMGLGRRNSSQVSLDSHAGSVPGSMDGINL 454
            :|..|                        ||.......|||...|..||.:.:||
 Frog  1677 DGRET------------------------DSASESSFQLGRHKKSPSSLTNLSGS---------- 1707

  Fly   455 ERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVLEAKGL-ICPFS 518
             ..::..|..|.|.:.:...|.....|.|.:...|:|     ::...|..|.|.:.|.| .....
 Frog  1708 -SGMASLSSVSGSVMSIYSGDFGNVDIKGNIQFALDY-----ADNLQEFQVFVSQCKDLAAADVK 1766

  Fly   519 VESLDTFVRIYLVPDHP--GAMQTKVVKGTLTPSYNESFDFWLHK-----RQARHSLWFH--LYH 574
            .:..|.:|:.||:|:..  |..:|.|.|.||.|.||:...:.:.|     :....|:|.|  |..
 Frog  1767 KQRSDPYVKAYLLPEKAKMGKRKTGVKKKTLNPVYNDVLRYKISKNALLSQTLNLSVWHHDVLGR 1831

  Fly   575 NGPAHTLIGEAEMEIG--EMPRPITTWIPLS----------DSRKCNARWGELMFSLSYLPTA-- 625
            |    :.:||.::.:.  :.......|.||.          ::|      ||:..:|.|:|.|
 Frog  1832 N----SFLGEVDVNLASWDWSNKQMNWYPLQPRTPAAGIGLENR------GEMKLALKYVPEAFT 1886

  Fly   626 -------ERLTIVVVKARNL-KLDGEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRS 682
                   ..:.|.:.:..|| .|.|.:        ::| |:|..::....:..:::|....|..:
 Frog  1887 GAKNAGTGEVHIWLKECTNLPMLRGNK--------INS-FIKCTILPDTSRKSRQKTRAVDKTPN 1942

  Fly   683 PIFNESMIF 691
            |.||.:|::
 Frog  1943 PYFNHTMVY 1951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	27/110 (25%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	20/90 (22%)
sytl2	XP_012812257.2	PHD_SF	5..>44	CDD:473978
		C2A_SLP-1_2	1734..1858	CDD:176039	32/132 (24%)
		C2B_SLP_1-2-3-4	1871..2027	CDD:175987	21/96 (22%)