Protein Alignment Syt12 and Syt4

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_477464.1
• Gene: Syt4 / 40876
• FlyBaseID: FBgn0028400
• Length: 474
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 129/538 - (23%)
• Similarity: 217/538 - (40%)
• Gaps: 133/538 - (24%)

  Fly   279 EQIPSNPISEPLNATVASLEKTTISTSECTPITAPLETPNGPISTDTPSTIHHNGNPFVERESLS 343
            |.||...:.:.:...:..|....:.:|........:...|...|.      |....||
  Fly     4 EYIPDASVMDTIVPAILGLTAAAVLSSVACICARQMRLRNKKQSQ------HDASFPF------- 55

  Fly   344 SRLLKIHNTTNPFTGLSQRVKGPHLLQKTISEDYLFRKLGVNCPMAN----------------GN 392
                  ..|..|....|...:.||.|:|:.|... .:::|:..||.:                |:
  Fly    56 ------QPTRRPTAVRSPSGQPPHYLKKSPSPTG-GKQMGLLSPMQDQSTSPIAQPNVKYSEEGD 113

  Fly   393 GTGPGSGHVNGN------GNGTWSFGRSLLRQDSTLSLGMGLGRRNSSQVSLDSHAGSVPGSMDG 451
            |....:...|||      |||......:.|......::..|     |..::||.|
  Fly   114 GPAQHAEQQNGNQLTVVDGNGLKHSLHNSLHHSPVETIANG-----SVTITLDDH---------- 163

  Fly   452 INLERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVLEAKGLIC- 515
                      |:|:...|.:  .||       |..:|..|.::....|...|.||::..:||.|
  Fly   164 ----------SLTNGKELTV--TDQ-------YGKLGTIYFKLRYLAERNALMVSIIRCRGLPCK 209

  Fly   516 ---------PFSVE-----SLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESFDFW-LHKRQAR 565
                     |..:.     :.|.:|::.|:||....::|:||:.|..|.|:|.|.|: |:....:
  Fly   210 GGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQ 274

  Fly   566 H-SLWFHL--YHNGPAHTLIGE-----AEMEIGEMPRPITTWIPLSDSRKCNAR--------WGE 614
            : ||.|.:  :.......:|||     ..:|||::.:.     .||.|::...|        .||
  Fly   275 NMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKE-----ALSISKEIQPRSLKIRAQGRGE 334

  Fly   615 LMFSLSYLPTAERLTIVVVKARNL-KLDGEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKR 678
            |:.||.:.|.|.|||:|::||||| ::|        ...:...:||:||:...:::.||:|.:|:
  Fly   335 LLISLCWQPAAGRLTVVLLKARNLPRMD--------VTGLADPYVKIYLLYNGQRIAKKKTHVKK 391

  Fly   679 KDRSPIFNESMIFSVPP-----PSLTTTQLRVTVFG---VTTSGVTPLGHI-VAGSCAVGKGLRH 734
            :..||:||||..|.:|.     .||....|.:.:..   ||.:.|  :|.: :.|..:....|.|
  Fly   392 RTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEV--IGRLELGGPNSSSTALNH 454

  Fly   735 WHQMLSSLRKPVAMWHVL 752
            |:::.:|.|:.:|.||.|
  Fly   455 WNEVCNSPRRQIAEWHKL 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	31/122 (25%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	50/151 (33%)
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	37/147 (25%)
		C2B_Synaptotagmin-4	332..473	CDD:176049	50/151 (33%)