Protein Alignment Syt12 and Rph

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_572651.1
• Gene: Rph / 32002
• FlyBaseID: FBgn0030230
• Length: 638
• Species: Drosophila melanogaster
• Alignment Length: 516
• Identity: 105/516 - (20%)
• Similarity: 194/516 - (37%)
• Gaps: 116/516 - (22%)

  Fly   304 TSECTPITAPLETPN---GPISTDTPSTIHHNGNPFVERESLSSRL-LKIHNTTNPFTGLSQRVK 364
            ::..|||      ||   |.::.||.:....:..|  .|.:...:| ::::::::..:|.|:
  Fly   165 SASATPI------PNPGPGSMAGDTRAVQSCHATP--TRPARVKKLTIRVNDSSSSSSGHSE--- 218

  Fly   365 GPHLLQKTISEDYLFRKLGVNCPMANGNGTGPG--------------------SGHVNGNG---N 406
                     .||.:...:|:...:. |.|...|                    ...::|..   :
  Fly   219 ---------PEDEVDTGVGIGVGVV-GGGMAKGIASTRLQREDSFRLRAYGSIRSFIDGGERKLS 273

  Fly   407 GTWSFGRSLLRQDSTL----SLGMGLGRRNSSQVSLDSHAGSVPGSMDGINLERAISCDSVTSDS 467
            .::.|.|...::.|..    |:.|...||.||.:    ..|||..|.       :||..|.:..:
  Fly   274 NSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFL----RRGSVSSSW-------SISDSSGSGSN 327

  Fly   468 TLFLDQLDQPYTQ------------ITGYLCVGLNYDQMSISNEGMELTVSVLEAKGLICPFSVE 520
            .....|....|.|            :.|:|.:.::|.:...|     |..:::.|:.|....:..
  Fly   328 NSGNSQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHS-----LDCTMVRARDLPAMDAAG 387

  Fly   521 SLDTFVRIYLVPDHPGA-------MQTKVVKGTLTPSYNESFDF-WLHKRQARHSL-WFHLYHNG 576
            ..|.:.::.::.  |.|       .:||.|..|..|.:||:..| .:...:..:|| :..|:.:.
  Fly   388 LADPYCKLNIIT--PEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDD 450

  Fly   577 P-AHTLIGEAEMEIG--------EMPRPITTWIPLSDSRKCNARW--GELMFSLSYLPTAERLTI 630
            . .|..:|.|::.:.        .:..|:......|::.:....|  |:::.||.|......|.:
  Fly   451 KYGHDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVV 515

  Fly   631 VVVKARNLKLDGEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIFSVPP 695
            .|.:..||.......:.:.       |||:.|.....|..|.:||:|.:..:||:||...|...|
  Fly   516 NVKQCINLMAMDNNGSSDP-------FVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASP 573

  Fly   696 PSLTTTQLRVTVFGVTTSGVTP-LGHIVAGSCAVGKGLRHWHQMLSSLRKP---VAMWHVL 752
            ..|....|.:||:......... ||.:..|:.:.|:.|:.|   |..:|.|   ...||.|
  Fly   574 HDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQW---LDCIRLPDHFHEKWHCL 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	21/116 (18%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	40/147 (27%)
Rph	NP_572651.1	FYVE_like_SF	84..172	CDD:333710	3/12 (25%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	24/129 (19%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	37/141 (26%)