Protein Alignment Syt12 and Sytl5

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_848016.2
• Gene: Sytl5 / 302538
• RGDID: 631342
• Length: 753
• Species: Rattus norvegicus
• Alignment Length: 820
• Identity: 168/820 - (20%)
• Similarity: 271/820 - (33%)
• Gaps: 259/820 - (31%)

  Fly    18 LGILF----ACHCLGPRAANWMRMRSSKEEKIGLSNHKQKLFHANGYMASIQSGSEFLLSTSGSF 78
            ||::|    .|.....|..:..|:       .||....:....|......|.||..||...:..|
  Rat    71 LGLIFDRGDPCQACSLRVCSECRV-------TGLDGSWKCTVCAKVAQLRIISGEWFLEEKAKRF 128

  Fly    79 KRFDTI--------------DKEDYNRSQQTHQTHLFLMNGGGAVSITGSSSALQAT-------- 121
            |:.:.:              ..|:....:|.||        |...|.|.||...:||
  Rat   129 KQVNVLGTDVVRQSILRRSPGSEEIQNQEQAHQ--------GADKSDTLSSVRQKATHDGPKRKG 185

  Fly   122 ---TAMWHLPRSGIKIPPPPDRPAPSPNSAAAAGKTVTFSLSQVNEVIMPGEQVTSNDQERRSCL 183
               :......|..||.|            .|.:|:  ::||...|:.:...:.|:.:|  |.|..
  Rat   186 FLLSKFRSATRGEIKTP------------KAESGR--SYSLDLDNQNLQSFKSVSGSD--RGSTT 234

  Fly   184 RQN--------GGTAGGAGGGGVLPQPLEAPPPPRLTASTSVNLSGTAIPRPIAKRQVSTQPANN 240
            ..:        |...|....||: |....:|.|                    :.|.|::..:..
  Rat   235 SSDLIDQEAGRGAPKGSCSNGGI-PVTQRSPAP--------------------SARSVTSISSRE 278

  Fly   241 SGCQPEQTVVTPMREGERKAPALKRRNSSTNPFLCESTEQIPSNPISEPLNATVASLEKTTISTS 305
            .|.:....:.|.....|....: .|||:|..|.:..|...:.|......|:.:.:..|
  Rat   279 HGFENSMALATIESISEELTKS-HRRNTSGTPSIAVSGTSLSSERSRSELDLSESFAE------- 335

  Fly   306 ECTPITAPLETPNGPISTDTPSTIHHNGNPFVERES----LSSRLLKIHNTTNPFTGLSQRVKGP 366
                   .||..:...|...|..:..:.|...:.|.    :|||...  ||.:..:|||
  Rat   336 -------DLEDTSSIRSRSVPGALDKDLNSLEDTEDGVDLVSSRFSA--NTHSLASGLS------ 385

  Fly   367 HLLQKTISEDYLFRKLGVNCPMANGNGTGPGSGHVNGNGNGTWSFGRSLLR----QDSTLSLGMG 427
                 |.|:....||                               ||.|.    ...|.||
  Rat   386 -----TSSQAGSDRK-------------------------------RSYLHVPDADSDTTSL--- 411

  Fly   428 LGRRNSSQVSLDSHAGSVPGSMDGINLERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGL-NY 491
                 :|.:|:.|..|.. |::            .||.:..|.:.     |...||.|.:.: |.
  Rat   412 -----NSMMSVYSETGDY-GNV------------KVTGEILLHIS-----YCYKTGGLYIFVKNC 453

  Fly   492 DQMSISNEGMELTVSVLEAKGLICPFSVESLDTFVRIYLVPD--HPGAMQTKVVKGTLTPSYNES 554
            ..::|.:|..:.|                  |.:|:.||:||  .....:||:..|| .|.:||:
  Rat   454 RNLAIGDEKKQRT------------------DAYVKSYLLPDKTRNNKRKTKIRTGT-NPEFNET 499

  Fly   555 FDF-----WLHKRQARHSLWFHLYHNGPAHTLIGEAEM--EIGEMPRPITTW------IPLSDSR 606
            ..:     .|..|..:.|:|.  |.....::.:||.|:  :......|...|      :.|:...
  Rat   500 LKYTISHTQLETRTLQLSVWH--YDRFGRNSFLGEVEIAFDSWNFENPCDEWFVLQPKVELAPDI 562

  Fly   607 KCNARWGELMFSLSYLPTAERLTIVVVKARNLKL-----DGEQPA---------PESAETVHSV- 656
            ....: |||...|.|:|..|.|...|.:.:..|:     ..|.||         .:.|:.:.:|
  Rat   563 SLQYK-GELTIVLRYIPPEENLIFPVEQPQGKKIFKKGKKKESPAISGGILEVFIKEAKNLTAVK 626

  Fly   657 -------FVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIFS-VPPPSLTTTQLRVTVF----- 708
                   |||.||:..|.|..|.:|::.:|..:|.:|...||| :.|..:....|.:|::
  Rat   627 AGGTSDSFVKGYLLPDDNKATKHKTAVVKKSVNPQWNHVFIFSGLYPQDIQNACLELTIWDKEAF 691

  Fly   709 -------GV---TTSGVTPLGHIVAGSCAVGKGLRHWHQM 738
                   ||   :.||::. |..|....:.|:..|.|.:|
  Rat   692 SSNIFLGGVRLNSGSGISH-GKAVDWMDSRGEEQRLWQKM 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	24/113 (21%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	43/165 (26%)
Sytl5	NP_848016.2	PHD_SF	11..123	CDD:473978	14/58 (24%)
		FYVE_Slp5	62..108	CDD:277305	8/43 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..188		11/50 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..283		14/84 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..359		14/75 (19%)
		C2A_SLP-4_5	430..553	CDD:175995	33/148 (22%)
		C2B_SLP_1-2-3-4	567..745	CDD:175987	43/166 (26%)