Protein Alignment Syt12 and Sytl4

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_038785.1
• Gene: Sytl4 / 27359
• MGIID: 1351606
• Length: 673
• Species: Mus musculus
• Alignment Length: 793
• Identity: 169/793 - (21%)
• Similarity: 287/793 - (36%)
• Gaps: 213/793 - (26%)

  Fly    16 LILGILFACHCLGPRAANWMRMRSSKEEKIGLSNHKQK---LFHANGYMASIQSGSEFLLSTSGS 77
            ||||:|.....|  |.|:..|:|..|.|.:.:.....|   ..:::...|..|.|...|:..|.:
Mouse    17 LILGVLQRDEEL--RKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQEGLGRLIPKSST 79

  Fly    78 FKRFDTIDKEDYNRSQQTHQTHLFLMNGGGAVSITGSSSALQATTAMWHLP--------RSGIKI 134
            ....:.:         ...:..:...||.....:......|:..|..|...        |:|.:|
Mouse    80 CVGCNHL---------VCRECRVLESNGSWRCKVCSKEIELKKATGDWFYDQKVNRFDYRTGSEI 135

  Fly   135 PPPPDRPAPSPNSAAAAGKTVTFSLSQVNEV--IMPGEQVTSNDQER-RSCLRQNGGTAGGAGGG 196
            .....|..|:.|....||:    ||.|..::  |.||.::....|:| :|.|.:...|..|...
Mouse   136 IRMSLRQKPAVNKRETAGQ----SLLQQTQMGDIWPGRRIIQEQQQREQSVLFEVPKTRSGKSA- 195

  Fly   197 GVLPQPLEAPPPPRLTASTSVNLSGTAIPRPIAKRQVSTQPANNSGCQPE-QTVVTPMREGERKA 260
                  |||       .|.|:: |.||.....::|    ...:.||..|| :.:..|..:.|::.
Mouse   196 ------LEA-------ESESLD-SYTADSDSTSRR----DSLDKSGLFPEWKKMSAPKSQVEKEI 242

  Fly   261 PALKRRNSSTNPFLCESTEQIPSNPISEPLNATVASLEKTTISTSECTPITAPLETPNGPISTDT 325
            |                    |.|.     || |...|...:.......:..|.|.....|....
Mouse   243 P--------------------PGNQ-----NA-VCGDEGDMVFKKNTKKVLRPSEYTKSVIDLRP 281

  Fly   326 PSTIHHNGNPFVERESLSSRLLKIHNTTNPFTGLSQRVKGPHLLQKTISEDYLFRKLGVNCPMAN 390
            ......:|            :|...:.:.|  |||..::.....::.|  |:|.:.
Mouse   282 EDVAQESG------------ILGDRSKSVP--GLSVDMEEEEEEEEDI--DHLVKL--------- 321

  Fly   391 GNGTGPGSGHVNGNGNGTWSFGRSLLRQDSTLSLGMGLGRRNSSQVSLDSHAGSVPGSMDGINLE 455
                     |......|:...|.|:    |||          .|.:|:.|.||
Mouse   322 ---------HRQKLARGSMQSGSSM----STL----------GSIMSIYSEAG------------ 351

  Fly   456 RAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVLEAKGLICPFSVE 520
                               |.....:||.:...|.::|.:     ..|.:.|.|...|  .::.|
Mouse   352 -------------------DFGNISVTGKIAFSLKFEQKT-----QTLVIHVKECHQL--AYADE 390

  Fly   521 S---LDTFVRIYLVPD--HPGAMQTKVVKGTLTPSYNESFDFWLHKR-QARHSLWFHLYHNG--P 577
            :   .:.:|:.||:||  ..|..:|.:.:.|:.|.|:|:|.:.:.:. .|:.:|.|.::|:|  .
Mouse   391 AKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETFRYEISESLLAQRTLQFSVWHHGRFG 455

  Fly   578 AHTLIGEAE--MEIGEMPRPITTWIPL------SDSRKCNARWGELMFSLSYLPTAE-------- 626
            .:|.:||||  |:..::.:.:...:||      ..|....|..|||:.||.|:|.::
Mouse   456 RNTFLGEAEVHMDSWKLDKKLDHCLPLHGKISTESSPGLPAHKGELVVSLKYIPASKLPVGGDRK 520

  Fly   627 --------RLTIVVVKARNLKLDGEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSP 683
                    .|.:.:.:|:||      .|.:|..|..| |||.||:....|..|::|.:.:|..||
Mouse   521 KSKGGEGGELQVWIKEAKNL------TAAKSGGTSDS-FVKGYLLPMRNKASKRKTPVMKKTLSP 578

  Fly   684 IFNESMIFS-VPPPSLTTTQLRVTVFGVTTSGVTP-LGHIVAGSCAVGKGLRH-----WHQMLSS 741
            .:|.:.::: |....|....|.:||:......... ||.:..|   ||.|:.:     |   :.|
Mouse   579 HYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLG---VGTGISNGEVVDW---MDS 637

  Fly   742 LRKPVAMWHVLRR 754
            ..:.|::|..:|:
Mouse   638 TGEEVSLWQKMRQ 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	28/108 (26%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	42/163 (26%)
Sytl4	NP_038785.1	PHD_SF	8..121	CDD:473978	23/114 (20%)
		FYVE_Slp4	58..107	CDD:277303	7/57 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..253		23/113 (20%)
		C2A_SLP-4_5	359..483	CDD:175995	33/130 (25%)
		C2B_SLP_1-2-3-4	498..663	CDD:175987	43/166 (26%)