Protein Alignment Syt12 and Syt16

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001351210.1
• Gene: Syt16 / 238266
• MGIID: 2673872
• Length: 654
• Species: Mus musculus
• Alignment Length: 804
• Identity: 154/804 - (19%)
• Similarity: 265/804 - (32%)
• Gaps: 267/804 - (33%)

  Fly    47 LSNHKQKLFHANGYMASIQSGSEFLLSTSGSFKRFDTIDKEDYNRSQQTH-----QTH------- 99
            ||:...:::.|........|.|..|||...|..........|..:.|||:     |.|
Mouse    17 LSSWLSRVYEALQQAGDALSASLVLLSKHDSALSDKPEQDLDAAQIQQTYLEDEEQDHDGSPEEA 81

  Fly   100 --LFLMNGGGAVSITGSSSALQ-ATTAMWHLPRSGIKIPPP-----PDRPAPSPNSAAAAGKTVT 156
              |||.....::|.:....::| |:..:.........:.||     |..|.|.|
Mouse    82 SSLFLEEDHFSLSNSDLQDSVQTASPTLGQQAEDSSSVIPPWPSKIPGAPKPQP----------- 135

  Fly   157 FSLSQVNEVIMPGEQVTSNDQERRSCLRQNGGTAGGAGGGGVLPQPLEAPPPPRLTASTSVNLSG 221
             .||.:.|        ..:..||:.|.||:|                                ||
Mouse   136 -VLSSIAE--------EDHHSERQRCGRQHG--------------------------------SG 159

  Fly   222 TAIPRPIAKRQVST-----QPANNSGCQPEQT----VVTPMREGERKAPALKRRNSSTNP----- 272
            | :.:...::||::     :|:.:|....:.|    :.....:..|...:.|.:.:....
Mouse   160 T-LEKVNGRKQVNSFGDDEEPSTSSESDEDVTKQFKISVSRSQSFRSGVSEKGKTTELEQKIKCK 223

  Fly   273 -FLCESTEQIPSNPISEPLNAT--------VASLEKTT-ISTSECTPITAPLETPNGPISTDTPS 327
             .||...|........|.::.:        |..|::|: :|.||.      |...:.|||....|
Mouse   224 RLLCTHQEDSAEGSACEGIHCSALHCRQGQVNDLDRTSQLSYSEI------LSYEDRPISILPQS 282

  Fly   328 TIHHNGNPFVERESLSSRLLKIHNTTNPFTGLSQRVKGPHLLQKTISEDYLFRKLGVNCPMANGN 392
                   ||      .||.::.|....|..|                   :.|.||..|  |:|
Mouse   283 -------PF------ESRNVRHHGPCRPEMG-------------------MVRSLGRPC--ADG- 312

  Fly   393 GTGPGSGHVNGNGNGTWSFGRSLLRQDSTLSLGMGLGRRNSSQVSLDSHAGSV--PGSMDGINLE 455
                                   :.:..|..:..|.      :.|..:|:.|:  |...||.:|:
Mouse   313 -----------------------VLETETAFVSRGF------EDSYATHSSSLWSPEEQDGTSLQ 348

  Fly   456 ---RAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVLEAKGLICP- 516
               |.:...|...|..:..:     |..:|                  .:|||:::.|:||  |
Mouse   349 VPHRLLEPISKCGDLDVIFE-----YRAVT------------------QKLTVTIVRAQGL--PD 388

  Fly   517 ---FSVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNES-----------------FDFWLHK 561
               ..|.|..  |.|.|:|......:|.:.:|. .|.:.|.                 |..:..:
Mouse   389 KDRSGVNSWQ--VHIVLLPSKKQRGKTNIQRGP-NPVFKEKVTFTKLEPRDVASCAVRFRLYAAR 450

  Fly   562 RQARHSLW----FHLYHNGPAHTLIGEAEMEI------------GEMPRPITTWIPLSDSRKCNA 610
            :..|..:.    |.|.|..|      |.||::            ||.|...:. :..|||.....
Mouse   451 KMTRERMMGEKLFCLSHLHP------EGEMKVTLVLEPRSNLSSGESPLSPSV-VSHSDSASSTQ 508

  Fly   611 RWG-----ELMFSLSYLPTAERLTIVVVKARNLKLDGEQPAPESAETVHSVFVKVYLMD-KDRKV 669
            ...     ||:..|||..|..||::.::|..:.:......||::       :.|::|:: ..:::
Mouse   509 SLSHGGVPELLVGLSYNATTGRLSVEMIKGSHFRNLAANRAPDT-------YGKLFLLNCVGQEM 566

  Fly   670 LKKRTSLKRKDRSPIFNESMIFSVPPPSLTTTQLRVTVFGVTTS------GVTPLGHIVAGSCAV 728
            .:.:||::|...:|::.|:.:|.|....|:...|.::::...|.      |...||...:|.
Mouse   567 SRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISIYSRRTMKRKEMIGWVALGQNSSGE--- 628

  Fly   729 GKGLRHWHQMLSSLRKPVAMWHVL 752
             :...||.:|..|..:....||.|
Mouse   629 -EEQEHWEEMKESKGQQTCRWHTL 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	29/135 (21%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	34/153 (22%)
Syt16	NP_001351210.1	C2A_Synaptotagmin-14_16	359..482	CDD:176035	29/156 (19%)
		C2B_Synaptotagmin-14_16	515..652	CDD:176053	34/148 (23%)