Protein Alignment Syt12 and Syt2

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_033333.2
• Gene: Syt2 / 20980
• MGIID: 99666
• Length: 422
• Species: Mus musculus
• Alignment Length: 461
• Identity: 126/461 - (27%)
• Similarity: 198/461 - (42%)
• Gaps: 84/461 - (18%)

  Fly   308 TPITAPLETPNGPISTDTPSTIHHNGNPFVERESLSSRLL-KIHNTTN-----PFTGLSQRVKGP 366
            |..|.|| .|..|....|.||     .|...:|.:.::|. |..|..|     |:..::..|...
Mouse    18 TTATMPL-APVAPADNSTEST-----GPGESQEDMFAKLKEKFFNEINKIPLPPWALIAMAVVAG 76

  Fly   367 HLLQKTISEDYLFRKLGVNCPMANGNGTGPGSGHVNGNGNGTWSFGRSLLRQDSTLSLGMGLGRR 431
            .||.....  .:.:|.   |.....|....|.|..|                      .|.:...
Mouse    77 LLLLTCCF--CICKKC---CCKKKKNKKEKGKGMKN----------------------AMNMKDM 114

  Fly   432 NSSQVSLDSHAGSVPGSMDGINLERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSI 496
            ...|...|:..|...|..:|                    ::..:|  :..|.|...|:||
Mouse   115 KGGQDDDDAETGLTEGEGEG--------------------EEEKEP--ENLGKLQFSLDYD---- 153

  Fly   497 SNEGMELTVSVLEAKGLICPFSVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESFDFWL-H 560
             .:..:|||.||:|..|.......:.|.:|:::|:||.....:|||.:.||.|::||:|.|.: :
Mouse   154 -FQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPY 217

  Fly   561 KRQARHSLWFHLY--HNGPAHTLIGEAE--MEIGEMPRPITTWIPLSDSRKCN-ARWGELMFSLS 620
            :.....:|...:|  .....|.:|||.:  |...::.:||..|..|....|.. .:.|::..||.
Mouse   218 QELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLR 282

  Fly   621 YLPTAERLTIVVVKARNL-KLD-GEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSP 683
            |:|||.:||:.:::|:|| |:| |....|         :||::||...:::.||:|::|:|..:|
Mouse   283 YVPTAGKLTVCILEAKNLKKMDVGGLSDP---------YVKIHLMQNGKRLKKKKTTVKKKTLNP 338

  Fly   684 IFNESMIFSVPPPSLTTTQLRVTVFGVTTSGVT-PLGHIVAGSCAVGKGLRHWHQMLSSLRKPVA 747
            .||||..|.:|...:...|:.|||......|.. .:|.|..||.|.|..||||..||::.|:|:|
Mouse   339 YFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIA 403

  Fly   748 MWHVLR 753
            .||.|:
Mouse   404 QWHSLK 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	32/103 (31%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	54/143 (38%)
Syt2	NP_033333.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		10/30 (33%)
		Syt2_N	4..116	CDD:409249	26/130 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..141		10/82 (12%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		80/261 (31%)
		C2A_Synaptotagmin-1-5-6-9-10	142..264	CDD:176031	37/126 (29%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	54/143 (38%)