Protein Alignment Syt12 and rbf-1

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001367825.1
• Gene: rbf-1 / 175943
• WormBaseID: WBGene00004316
• Length: 1123
• Species: Caenorhabditis elegans
• Alignment Length: 813
• Identity: 162/813 - (19%)
• Similarity: 270/813 - (33%)
• Gaps: 238/813 - (29%)

  Fly   105 GGGAVSIT-GSSSALQATTAMWHLP----RSGIKIPPPPDRPAPS-------------PNSAAAA 151
            |.|...:| .|:|:.|.||..|..|    ..|:::...|..|.|:             |:|:..:
 Worm   380 GAGPQPMTMPSTSSCQMTTPKWASPGVCNSPGLQMNGGPTSPLPNGTRRNTGHGGIEFPSSSRPS 444

  Fly   152 GKTVTFSLSQ---------------VNEVIMPGEQV-------TSNDQE--------RRSCLRQN 186
            ..:|..::..               |||.:|....|       :|:|.|        ||:.   |
 Worm   445 ICSVLQAIEPLDRSKSPRPRIQPRWVNEKVMSSMSVDDEEKAASSSDGESFVQSGVPRRAL---N 506

  Fly   187 GGTAGGAGGGGVLPQPLEAPPPPRLTASTSVNLSGTAIPRPI---AKRQVSTQPANNS------- 241
            ..|..|:......|    ||||...|.::....:.....|..   |.|..||...::|
 Worm   507 NKTPVGSTSATTSP----APPPTSTTPTSRREANMERFSRHTHAHANRLYSTDDDDDSSPESRPS 567

  Fly   242 --GCQPEQTVVTPMREGERKAPALKRRNSSTNPFLCESTEQIPSNPISEPLNATVASL------- 297
              ...|..::.||..............::.|........:...|||....|..:.:||
 Worm   568 TRSTSPRHSLATPSSYAHDTCHDTSLPDADTRSIDSGVVQSDHSNPQQSGLTCSSSSLTPLQQQA 632

  Fly   298 -----------------EKTTISTSECTPITAPLETPNGPISTDTPSTIHHNGNPFVERESLSSR 345
                             ::||...::....|: |.||..|||:.| |..:.|.:|....|..||.
 Worm   633 SHDHHSGGGTPRRISNPDRTTSRVAQSASGTS-LVTPPPPISSRT-SPDNCNSSPLNVMEHKSSS 695

  Fly   346 LLKIHNTTNPFTGLSQRV-KGPHLLQKTISEDYLFRKL-----GVNCPMANGNGTGPGSGHVNGN 404
            .....:..|...|.::.| ...|.:....:.:.:.:||     ....|:|      ..|..::..
 Worm   696 ASTASSGGNRRVGSAEPVLNNHHAMHNNQNHNDINKKLISQTSRAESPLA------ASSSFLSSP 754

  Fly   405 GNGTWSFGRSLLRQDSTLSLGMGLGRRNSSQV--SLDSHAGSVP--GSMDGINLERAISCDSVTS 465
            .:.|....|   |:|       |:||.||.|:  |||..|..|.  ..|:|    ..:|.:..:|
 Worm   755 DDDTKQKNR---RRD-------GVGRVNSLQLRTSLDDVAPPVAPISKMNG----HIVSSEPTSS 805

  Fly   466 DSTLFLDQLDQPYTQI-----------------------------TGYLCVGLNYDQMSISNEGM 501
            .::      :|.:|.:                             .|.:.:.|.|     .:...
 Worm   806 TTS------NQNHTSVPIPTVPVVPEEEEEKAITASTESASEPGSLGSITLTLTY-----HSADK 859

  Fly   502 ELTVSVLEAKGLICPFSVESLDTFVRIYLVPDHPGA--MQTKVVKGTLTPSYNESFDFWLHKRQA 564
            :|.:.::.||.|....|....|.:|:.:|:|.:..|  :.:|.::.||.|.:||...::
 Worm   860 KLKMHLIRAKNLKAMDSNGFSDPYVKFHLLPGNTKATKLTSKTIEKTLNPEWNEEMSYY------ 918

  Fly   565 RHSLWFHLYHNGPAHTLIGEAEMEIGEMPRPITTWIPLSDSRKCNARWGELMFSLSYLPTAERLT 629
                       |     |.|.:.|     :.|.....|...|..:...||...:|..|...|
 Worm   919 -----------G-----ITEDDKE-----KKILRVTVLDRDRIGSDFLGETRIALKKLNDNE--- 959

  Fly   630 IVVVKARNLKLDGEQPAPESAETVH------------------SVFV------------------ 658
               :|..||.|:...|.|:..:...                  |:|:
 Worm   960 ---MKKFNLYLESALPVPQQTKEEENEDRGKINVGLQYNIQQGSLFININRCVELVGMDSTGFSD 1021

  Fly   659 ---KVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIFSVPPPSLTTTQLRVTVFGVTTSGVTP-LG 719
               ||.|.....|..:.:||.|::..:|.:||.:.|.||...|....|::.|:......... :|
 Worm  1022 PYCKVSLTPITSKAHRAKTSTKKRTLNPEWNEQLQFVVPFKDLPKKTLQIGVYDHDLGKHDDYIG 1086

  Fly   720 HIVAGSCAVGKGLRHWHQMLSSLRKPVAMWHVL 752
            .|:..:.|..:..|.|.:.:.:....|..||.|
 Worm  1087 GILLSTSAKDERGRQWIKCIENPGTLVEAWHRL 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	21/100 (21%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	38/181 (21%)
rbf-1	NP_001367825.1	FYVE_2	219..342	CDD:426716
		C2A_Rabphilin_Doc2	845..967	CDD:176000	34/159 (21%)
		C2B_Rabphilin_Doc2	987..1119	CDD:176030	26/131 (20%)