Protein Alignment Syt12 and SYT6

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001353153.1
• Gene: SYT6 / 148281
• HGNCID: 18638
• Length: 528
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 157/635 - (24%)
• Similarity: 234/635 - (36%)
• Gaps: 218/635 - (34%)

  Fly   192 GAGGGGVLPQPLEA-----------PPPPRLTASTSVNLSGTAIPRPIAKRQVSTQP------AN 239
            ||||    |:..||           |||..|...|.              |....||      |.
Human     6 GAGG----PRCQEALAVLASLCRARPPPLGLDVETC--------------RSFELQPPERSPSAA 52

  Fly   240 NSGCQPEQTVVT----------------------PMREGERKAPALKRRNSSTNPFLCESTEQIP 282
            .:|.......|.                      |.|..|..:|      ||.||.|  ...|.|
Human    53 GAGTSVSLLAVVVIVCGVALVAVFLFLFWKLCWMPWRNKEASSP------SSANPPL--EALQSP 109

  Fly   283 S------NPISEPLNATVASLEKTTISTSECTPITAPLETPNGPISTDTPSTIHHNGNPFVERES 341
            |      :.:.:|  :|:..|| ..:..|..:|              |.|:.:..:....:.|.:
Human   110 SFRGNMADKLKDP--STLGFLE-AAVKISHTSP--------------DIPAEVQMSVKEHIMRHT 157

  Fly   342 LSSRLLKIHNTTNPFTGLSQRVKGPHLLQK--TISEDYLFRKLGVNCPMANGNGTGPGSGHVNGN 404
            ...|     .||.|.:.........||.::  ..|.||             ||...|.:....
Human   158 RLQR-----QTTEPASSTRHTSFKRHLPRQMHVSSVDY-------------GNELPPAAEQPT-- 202

  Fly   405 GNGTWSFGR---SLLRQDSTLSLGMGLGRRNSSQVSLDSHAGSVPGSMDGINLERAISCDSVTSD 466
                 |.||   .|.:|.                            |:||         :...|:
Human   203 -----SIGRIKPELYKQK----------------------------SVDG---------EDAKSE 225

  Fly   467 STLFLDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVLEAKGLICPFSVESLDTFVRIYLV 531
            :           |:..|.:...|.||.     |...|.|.:|:|..|.......|.|.:|:|||:
Human   226 A-----------TKSCGKINFSLRYDY-----ETETLIVRILKAFDLPAKDFCGSSDPYVKIYLL 274

  Fly   532 PDHPGAMQTKVVKGTLTPSYNESFDFWL-HKRQARHSLWFHL----YHNGPAHTLIGEAEM---- 587
            ||....:||:|.:.||.|:::|:|.|.: ::..|...|  ||    :.....|.:|||..:
Human   275 PDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKL--HLSVFDFDRFSRHDMIGEVILDNLF 337

  Fly   588 EIGEMPRPITTWIPLSDSRKCNARWGELMFSLSYLPTAERLTIVVVKARNLK---LDG-EQPAPE 648
            |..::.|..:.|..:..:...:...||:||||.|||||.|||:.|:|.||||   :.| ..|
Human   338 EASDLSRETSIWKDIQYATSESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDP--- 399

  Fly   649 SAETVHSVFVKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIFSVPPPSLTTTQLRVTV------ 707
                    :|||.|:...|::.||:|::|:...:|::||::||.:||.::....|.::|
Human   400 --------YVKVSLLCDGRRLKKKKTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRV 456

  Fly   708 -----FGVTTSGVTPLGHIVAGSCAVGKGLRHWHQMLSSLRKPVAMWHVL 752
                 .||...|:|          |.|.|..||::||:..|||:|.||.|
Human   457 GHNEIIGVCRVGIT----------AEGLGRDHWNEMLAYPRKPIAHWHSL 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	33/107 (31%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	58/156 (37%)
SYT6	NP_001353153.1	Cysteine motif. /evidence=ECO:0000250|UniProtKB:O35681	12..38		7/39 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..178		4/25 (16%)
		C2A_Synaptotagmin-1-5-6-9-10	230..354	CDD:176031	38/130 (29%)
		C2B_Synaptotagmin-3-5-6-9-10	363..496	CDD:176048	57/153 (37%)