DRSC/TRiP Functional Genomics Resources

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Protein Alignment Syt12 and Doc2b

DIOPT Version :10

Sequence 1:NP_572878.1 Gene:Syt12 / 32290 FlyBaseID:FBgn0261085 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_031899.2 Gene:Doc2b / 13447 MGIID:1100497 Length:412 Species:Mus musculus


Alignment Length:341 Identity:90/341 - (26%)
Similarity:146/341 - (42%) Gaps:61/341 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   443 GSVPGSMDGINLERAIS--------CDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQMSISNE 499
            |:.||...|.:..|..:        .|...||....|..||           ..|.|||   .|.
Mouse    91 GASPGPSPGPSPARPPAKPPEDEPDVDGYESDDCTALGTLD-----------FSLLYDQ---ENN 141

  Fly   500 GMELTVSVLEAKGLICPFSVESL-DTFVRIYLVPDHPGA--MQTKVVKGTLTPSYNESFDFW--- 558
            .:..|:|  :|||| .|.....| |.:|:::|:|....|  ::||.::.||.||:||:..::   
Mouse   142 ALHCTIS--KAKGL-KPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPSWNETLTYYGIT 203

  Fly   559 ---LHKRQARHSLWFH--LYHNGPAHTLIGEAEMEIGEM-PRPITTW-------IPL--SDSRKC 608
               :.::..|.|:...  ..||    ..|||..:.:.:: |....|:       :|:  ::.:..
Mouse   204 DEDMVRKTLRISVCDEDKFRHN----EFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKAEDKSL 264

  Fly   609 NARWGELMFSLSYLPTAERLTIVVVKARNLKLDGEQPAPESAETVHSVFVKVYLM-DKDRKVLKK 672
            ..| |.::.||.|....:.|.:.:|:..:|       |...|......:||.||. |.|:| .|.
Mouse   265 EER-GRILISLKYSSQKQGLLVGIVRCAHL-------AAMDANGYSDPYVKTYLKPDVDKK-SKH 320

  Fly   673 RTSLKRKDRSPIFNESMIFSVPPPSLTTTQLRVTVFGVTTSGVTP-LGHIVAGSCAVGKGLRHWH 736
            :|::|:|..:|.|||...:.:....|....|.|||:......... :|.:|.|..|.|:.|:||.
Mouse   321 KTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGINAKGERLKHWF 385

  Fly   737 QMLSSLRKPVAMWHVL 752
            ..|.:..|.:..||.|
Mouse   386 DCLKNKDKRIERWHTL 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syt12NP_572878.1 C2 503..602 CDD:425499 30/117 (26%)
C2B_Synaptotagmin-12 612..753 CDD:176051 42/143 (29%)
Doc2bNP_031899.2 Mediates interaction with DYNLT1. /evidence=ECO:0000250 1..90
Negatively regulates targeting to plasma membrane 1..36
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..123 7/31 (23%)
C2A_Rabphilin_Doc2 127..250 CDD:176000 38/143 (27%)
Mediates interaction with STXBP3. /evidence=ECO:0000269|PubMed:17548353 257..375 33/126 (26%)
C2B_Rabphilin_Doc2 269..401 CDD:176030 40/139 (29%)
Blue background indicates that the domain is not in the aligned region.

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