Protein Alignment Syt12 and Doc2a

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_034199.1
• Gene: Doc2a / 13446
• MGIID: 109446
• Length: 405
• Species: Mus musculus
• Alignment Length: 437
• Identity: 108/437 - (24%)
• Similarity: 159/437 - (36%)
• Gaps: 118/437 - (27%)

  Fly   365 GPHLLQKTISEDYLFRKLGVNCPMANGNGTGPGSGHVNGNGNGTWSFGRSLLRQDSTLSLGMGLG 429
            ||....:.|| ||..|:           |.||..|   |.|.||                |.|..
Mouse    24 GPIRPIRQIS-DYFPRR-----------GPGPEGG---GGGGGT----------------GCGEA 57

  Fly   430 RRNSSQVSLDSHAGSVPGSMDGINLERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQM 494
            ..:.:.::|     :.|.::.|          :.|.|....:|..|...|...|.|...|.|||.
Mouse    58 PAHLAPLAL-----APPAALLG----------ATTPDDGAEVDSYDSDDTTALGTLEFDLLYDQA 107

  Fly   495 SISNEGMELTVSVLEAKGLICPFSVESL-DTFVRIYLVPDHPGA-----MQTKVVKGTLTPSYNE 553
            |..     |...:|.|||| .|.....| |.:|:::|:   |||     ::||..:.||.|.:||
Mouse   108 SCM-----LHCRILRAKGL-KPMDFNGLADPYVKLHLL---PGACKANKLKTKTQRNTLNPVWNE 163

  Fly   554 SF-------DFWLHKRQARHSLWFH--LYHNGPAHTLIGEAEMEIGEMPRP---------ITTWI 600
            ..       |...|| ..|.|:...  |.||    ..|||..:.:..: :|         :...:
Mouse   164 ELTYSGITDDDITHK-VLRISVCDEDKLSHN----EFIGEIRVPLRRL-KPSQKKHFNICLERQV 222

  Fly   601 PLSDSRKCNA-----------------------RWGELMFSLSYLPTAERLTIVVVKARNLKLDG 642
            ||......:|                       ..|.::.||||......|.:.:|:..:|
Mouse   223 PLPSPSSMSAALRGISCYLKELEQAEQGPGLLEERGRILLSLSYSSRRHGLLVGIVRCAHL---- 283

  Fly   643 EQPAPESAETVHSVFVKVYLM-DKDRKVLKKRTSLKRKDRSPIFNESMIFSVPPPSLTTTQLRVT 706
               |..........:||.||. |.|:| .|.:|.:|:|..:|.|||...:.:...:|.|..|.||
Mouse   284 ---AAMDVNGYSDPYVKTYLRPDVDKK-SKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVT 344

  Fly   707 VFGVTTSGVTP-LGHIVAGSCAVGKGLRHWHQMLSSLRKPVAMWHVL 752
            |:......... :|.:..|..|.|:..:||:..|......:..||.|
Mouse   345 VWDYDIGKSNDFIGGVSLGPGARGEAQKHWNDCLHQPDTALERWHTL 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	33/122 (27%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	40/143 (28%)
Doc2a	NP_034199.1	Interaction with UNC13D and DYNLT1. /evidence=ECO:0000250	1..94		25/115 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..54		11/49 (22%)
		C2A_Rabphilin_Doc2	95..218	CDD:176000	40/137 (29%)
		Interaction with UNC13D. /evidence=ECO:0000250	220..405		43/180 (24%)
		C2B_Rabphilin_Doc2	259..391	CDD:176030	38/139 (27%)