Protein Alignment Syt12 and SYT2

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_016855798.1
• Gene: SYT2 / 127833
• HGNCID: 11510
• Length: 479
• Species: Homo sapiens
• Alignment Length: 487
• Identity: 134/487 - (27%)
• Similarity: 210/487 - (43%)
• Gaps: 87/487 - (17%)

  Fly   286 ISEPLNATVASLEKTTISTSECTPITAPLET----PNGPISTDTPSTIHHNGNPFVERESLSSRL 346
            :|.|   .|:|.....|......||.||..|    |.||:...|.|     |.....:|.:.::|
Human    48 LSSP---AVSSATMRNIFKRNQEPIVAPATTTATMPIGPVDNSTES-----GGAGESQEDMFAKL 104

  Fly   347 L-KIHNTTN-----PFTGLSQRVKGPHLLQKTISEDYLFRKLGVNCPMANGNGTGPGSGHVNGNG 405
            . |:.|..|     |:..::..|....||.....  .:.:|.   |.....|....|.|..|...
Human   105 KEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCF--CICKKC---CCKKKKNKKEKGKGMKNAMN 164

  Fly   406 NGTWSFGRSLLRQDSTLSLGMGLGRRNSSQVSLDSHAGSVPGSMDGINLERAISCDSVTSDSTLF 470
            ......|:  |.||..                 |:..|...|..:|
Human   165 MKDMKGGQ--LPQDDD-----------------DAETGLTEGEGEG------------------- 191

  Fly   471 LDQLDQPYTQITGYLCVGLNYDQMSISNEGMELTVSVLEAKGLICPFSVESLDTFVRIYLVPDHP 535
             ::..:|  :..|.|...|:||     .:..:|||.||:|..|.......:.|.:|:::|:||..
Human   192 -EEEKEP--ENLGKLQFSLDYD-----FQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKK 248

  Fly   536 GAMQTKVVKGTLTPSYNESFDFWL-HKRQARHSLWFHLY--HNGPAHTLIGEAE--MEIGEMPRP 595
            ...:|||.:.||.|::||:|.|.: ::.....:|...:|  .....|.:|||.:  |...::.:|
Human   249 KKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQP 313

  Fly   596 ITTWIPLSDSRKCN-ARWGELMFSLSYLPTAERLTIVVVKARNL-KLD-GEQPAPESAETVHSVF 657
            |..|..|....|.. .:.|::..||.|:|||.:||:.:::|:|| |:| |....|         :
Human   314 IEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDP---------Y 369

  Fly   658 VKVYLMDKDRKVLKKRTSLKRKDRSPIFNESMIFSVPPPSLTTTQLRVTVFGVTTSGVT-PLGHI 721
            ||::||...:::.||:|::|:|..:|.||||..|.:|...:...|:.|||......|.. .:|.|
Human   370 VKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKI 434

  Fly   722 VAGSCAVGKGLRHWHQMLSSLRKPVAMWHVLR 753
            ..||.|.|..||||..||::.|:|:|.||.|:
Human   435 FVGSNATGTELRHWSDMLANPRRPIAQWHSLK 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	32/103 (31%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	54/143 (38%)
SYT2	XP_016855798.1	Syt2_N	61..170	CDD:409249	27/118 (23%)
		C2A_Synaptotagmin-1-5-6-9-10	199..321	CDD:176031	37/126 (29%)
		C2B_Synaptotagmin-1	331..466	CDD:176047	54/143 (38%)