Protein Alignment Syt12 and SYT15B

DIOPT Version :10

• Sequence 1: NP_572878.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001357111.1
• Gene: SYT15B / 102724488
• HGNCID: 51487
• Length: 474
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 87/282 - (30%)
• Similarity: 139/282 - (49%)
• Gaps: 24/282 - (8%)

  Fly   486 CVGLNYDQMSISNEGMELTVSVLEAKGLICPFSVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPS 550
            |:|..:..:....|...|.|.:::|:.|..|  .|:....|::||:||....:|:|..:.|..|.
Human   200 CLGRLWFSVEYEQEAERLLVGLIKAQHLQAP--SETCSPLVKLYLLPDERRFLQSKTKRKTSNPQ 262

  Fly   551 YNESFDFWL-HKRQARHSLWFHLYH--NGPAHTLIGEA------EMEIGEMPRPITTWIPL-SDS 605
            ::|.|.|.: .|...:..|.|.:||  ....|.|:|:.      |..:|:..|.|  |..| ::|
Human   263 FDEHFIFQVSSKTITQRVLKFSVYHVDRQRKHQLLGQVLFPLKNETLVGDCRRVI--WRDLEAES 325

  Fly   606 RKCNARWGELMFSLSYLPTAERLTIVVVKARNLKLDGEQPAPESAETVHSVFVKVYLMDKDRKVL 670
            .:..:.:|:|.|.|||.....|||:||::|:.|:|..::       .:.||||||.||:.::.|.
Human   326 LEPPSEFGDLQFCLSYNDYLSRLTVVVLRAKGLRLQEDR-------GIVSVFVKVSLMNHNKFVK 383

  Fly   671 KKRTSLKRKDRSPIFNESMIFSVPPPSLTTTQLRVTVF-GVTTSGVTPLGHIVAGSCAV--GKGL 732
            .|:||......:|::||:..|......|.|..|.:||. .:.......||.:|.|....  |:.|
Human   384 CKKTSAVLGSINPVYNETFSFKADATELDTASLSLTVVQNMEGDKSQQLGRVVVGPYMYTRGREL 448

  Fly   733 RHWHQMLSSLRKPVAMWHVLRR 754
            .||.:|||..::.|..||.|.|
Human   449 EHWDEMLSKPKELVKRWHALCR 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt12	NP_572878.1	C2	503..602	CDD:425499	31/107 (29%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	49/143 (34%)
SYT15B	NP_001357111.1	C2A_Synaptotagmin-15-17	202..322	CDD:176036	33/123 (27%)
		C2B_Synaptotagmin-15	332..469	CDD:176054	49/143 (34%)