Protein Alignment IP3K2 and Itpka

DIOPT Version :10

• Sequence 1: NP_572873.2
• Gene: IP3K2 / 32285
• FlyBaseID: FBgn0283680
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_112307.2
• Gene: Itpka / 81677
• RGDID: 619950
• Length: 459
• Species: Rattus norvegicus
• Alignment Length: 566
• Identity: 222/566 - (39%)
• Similarity: 279/566 - (49%)
• Gaps: 135/566 - (23%)

  Fly   111 LPDSP--LTSPTGGGNPSVGV---------PTKVLLEERVVA-----------APGSRRESTQSS 153
            ||..|  :..|.|.|..|.|:         ..::|.|.|..|           |.|::|...|..
  Rat     3 LPGHPTGMARPRGAGPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVP 67

  Fly   154 YSELGVSGLPLGVRYVRTPSVVVSDYSDDITACGISMEEMEYFRLQRARGQRRCSLEAGHHSHSG 218
                  :|||........|.:.|:...|
  Rat    68 ------NGLPRAAPAPVIPQLTVTSEED------------------------------------- 89

  Fly   219 GHGAHGHGGSGAAGMSPGCGKDDGQSDVSAASSCSNLYYCGSTISALDGGECIVNGVRVALARKS 283
                       .|..|||....:|....:|                   |..:....|::.:..|
  Rat    90 -----------VAPASPGPPDREGNWLPAA-------------------GSHLQQPRRLSTSSLS 124

  Fly   284 STQSSSLSDEEEEEEDDDEDRDEQDRDEDDRDAEEMLQEDYERGDRERERERQISELMAATQLGD 348
            ||.||||.    |:.:||...|.:.|               .||:.:.|....:.:
  Rat   125 STGSSSLL----EDSEDDLLSDSESR---------------SRGNVQLETSEDVGQ--------- 161

  Fly   349 RQRDRSKKSSGWRKIRNIVQWTPFFQTYKKQRYPWVQLAGHQGNFKAGPEPGTVLKKLCPKEEEC 413
                    .|.|:|||.:|. .|....:|| ||.|||||||.|:|||....|.:||:....|..|
  Rat   162 --------KSHWQKIRTMVN-LPVMSPFKK-RYSWVQLAGHTGSFKAAGTSGLILKRSSEPEHYC 216

  Fly   414 FQILMHDLLRPYVPVYKGQVTSEDGELYLQLQDLLSDYVQPCVMDCKVGVRTYLEEELSKAKEKP 478
            ...||.|:||..||.:.| |...|||.||||||||..:..|||:|||:||||||||||:||:|:|
  Rat   217 LVRLMADVLRGCVPAFHG-VVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERP 280

  Fly   479 KLRKDMYDKMIQIDSHAPTAEEHAAKAVTKPRYMVWRETISSTATLGFRIEGIKKSDGTSSKDFK 543
            |||||||.||:.:|..|||.||||.:||||||||.|||.|||:.|||||||||||:||:.|.|||
  Rat   281 KLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFK 345

  Fly   544 TTKSREQIKLAFLEFLSGHPHILPRYIQRLRAIRATLAVSEFFQTHEVIGSSLLFVHDQTH-ASI 607
            ||:||||:...|.||:.|...:|.||:.||:.||.||.:|:||:.|||||||||||||..| |.:
  Rat   346 TTRSREQVTRVFEEFMQGDAEVLKRYLNRLQQIRDTLEISDFFRRHEVIGSSLLFVHDHCHRAGV 410

  Fly   608 WLIDFAKTVELPPQLRIDHYSAWKVGNHEDGYLIGINNLIDIFVEL 653
            |||||.||..||....:||...|:.||.|||||:|::|||.|...|
  Rat   411 WLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILANL 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IP3K2	NP_572873.2	IPK	441..650	CDD:397715	136/209 (65%)
Itpka	NP_112307.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		8/22 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..164		33/223 (15%)
		IPK	243..453	CDD:397715	136/209 (65%)
		Calmodulin-binding	285..293		5/7 (71%)