Protein Alignment IP3K2 and ITPKA

DIOPT Version :10

• Sequence 1: NP_572873.2
• Gene: IP3K2 / 32285
• FlyBaseID: FBgn0283680
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_002211.1
• Gene: ITPKA / 3706
• HGNCID: 6178
• Length: 461
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 225/553 - (40%)
• Similarity: 278/553 - (50%)
• Gaps: 119/553 - (21%)

  Fly   119 PTGGGNPSVGVPTKVLLEERVVAAPGSRR---ESTQSSYSELGVSGLPLGVRYVRTPSVVVSDYS 180
            |||...|....|....||.....:.|..|   |:..::.:....:|.|
Human     7 PTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEP----------------- 54

  Fly   181 DDITACGISMEEMEYFRLQRARGQRRCSLEAGHHSHSGGHGAHGHGGSGAAGMSP---------- 235
                               ||||.:|          .||...:|...:..|.:.|
Human    55 -------------------RARGAKR----------RGGQVPNGLPRAPPAPVIPQLTVTAEEPD 90

  Fly   236 ----GCGKDDGQSDVSAASSCSNLYYCGSTISALDGGECIVNGVRVALARKSSTQSSSLSDEEEE 296
                ..|..:.:.|...|:..|:|.                ...|::.:..|||.||||.   |:
Human    91 VPPTSPGPPERERDCLPAAGSSHLQ----------------QPRRLSTSSVSSTGSSSLL---ED 136

  Fly   297 EEDDDEDRDEQDRDEDDRDAEEMLQEDYERGDRERERERQISELMAATQLGDRQRDRSKKSSGWR 361
            .|||                   |..|.|      .|.|...:|.|...:|.:..        |:
Human   137 SEDD-------------------LLSDSE------SRSRGNVQLEAGEDVGQKNH--------WQ 168

  Fly   362 KIRNIVQWTPFFQTYKKQRYPWVQLAGHQGNFKAGPEPGTVLKKLCPKEEECFQILMHDLLRPYV 426
            |||.:|. .|....:|| ||.|||||||.|:|||....|.:||:....|..|...||.|.||..|
Human   169 KIRTMVN-LPVISPFKK-RYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCV 231

  Fly   427 PVYKGQVTSEDGELYLQLQDLLSDYVQPCVMDCKVGVRTYLEEELSKAKEKPKLRKDMYDKMIQI 491
            |.:.| |...|||.||||||||..:..|||:|||:||||||||||:||:|:||||||||.||:.:
Human   232 PAFHG-VVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAV 295

  Fly   492 DSHAPTAEEHAAKAVTKPRYMVWRETISSTATLGFRIEGIKKSDGTSSKDFKTTKSREQIKLAFL 556
            |..|||.||||.:||||||||.|||.|||:.|||||||||||:||:.|.|||||:||||:...|.
Human   296 DPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFE 360

  Fly   557 EFLSGHPHILPRYIQRLRAIRATLAVSEFFQTHEVIGSSLLFVHDQTH-ASIWLIDFAKTVELPP 620
            ||:.|...:|.||:.||:.||.||.|||||:.|||||||||||||..| |.:|||||.||..||.
Human   361 EFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPD 425

  Fly   621 QLRIDHYSAWKVGNHEDGYLIGINNLIDIFVEL 653
            ...:||...|:.||.|||||:|::|||.|...|
Human   426 GQILDHRRPWEEGNREDGYLLGLDNLIGILASL 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IP3K2	NP_572873.2	IPK	441..650	CDD:397715	138/209 (66%)
ITPKA	NP_002211.1	Required for cytoskeleton location. /evidence=ECO:0000269|PubMed:12747803	1..133		33/187 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		7/21 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..160		36/200 (18%)
		IPK	245..455	CDD:397715	138/209 (66%)
		Calmodulin-binding. /evidence=ECO:0000250	287..295		5/7 (71%)