DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IP3K2 and itpka

DIOPT Version :9

Sequence 1:	NP_572873.2	Gene:	IP3K2 / 32285	FlyBaseID:	FBgn0283680	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001313405.1	Gene:	itpka / 368717	ZFINID:	ZDB-GENE-030616-116	Length:	448	Species:	Danio rerio

Alignment Length:	457	Identity:	196/457 - (42%)
Similarity:	269/457 - (58%)	Gaps:	23/457 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 QRRCSLEAGHHSHS------GGHGAHGHGGSGAAGMSPGCGKDDGQSDVSAASSCSNLYYCGSTI 262
            |||.||.....|.|      .|.|. |.||.|.||........|.|:.::...|..    .|...
Zfish     4 QRRRSLREAVCSRSSPVCDGSGRGG-GRGGGGRAGNFSSTQICDDQAQMAEQYSGQ----AGVLS 63

  Fly   263 SALDGGECIVNGVRVALARKSSTQSSSLSDEEEEEEDDDEDRDEQDRDEDDRDAEEMLQEDYERG 327
            .:..|..|.|..|.:.    |...|..:::|:.|||.:...|.:........:......::.| .
Zfish    64 DSHPGRGCTVPQVTIT----SDGDSREITEEDLEEEVNGRLRRKLSNSSISSNGSSTAFDESE-D 123

  Fly   328 DRERERERQISELMAATQLGDRQRDRSKKSSGWRKIRNIVQWTPFFQTYKKQRYPWVQLAGHQGN 392
            |...:.|.:...::....||| ..|.:::::.|.|::.||: .|...: :::|..|||||||:|:
Zfish   124 DLLSDNETKSKGIVTLEHLGD-SVDSAEQTNAWWKLKTIVK-CPLVAS-QRRRLSWVQLAGHKGS 185

  Fly   393 FKAGPEPGTVLKKLCPKEEECFQILMHDLLRPYVPVYKGQVTSEDGELYLQLQDLLSDYVQPCVM 457
            ||||.| |::|||....|..||:.|..|.|..:||.|.|.| ..||||:|::.|||:.:..|.||
Zfish   186 FKAGDE-GSILKKFSENENRCFERLKEDALHGFVPGYYGLV-KRDGELFLKMTDLLASFDTPNVM 248

  Fly   458 DCKVGVRTYLEEELSKAKEKPKLRKDMYDKMIQIDSHAPTAEEHAAKAVTKPRYMVWRETISSTA 522
            |||:|||||||:||.:|:.|||||:|:|:||:::||.||||||...|||||||||.|||::|||.
Zfish   249 DCKMGVRTYLEDELVRARVKPKLREDLYNKMLEVDSGAPTAEERQQKAVTKPRYMQWRESLSSTH 313

  Fly   523 TLGFRIEGIKKSDGTSSKDFKTTKSREQIKLAFLEFLSGHPHILPRYIQRLRAIRATLAVSEFFQ 587
            ||||||||||:.: |.:.|||.|:|:|.:...|.:|:.|:.:|:..||.||..|:..|..||||:
Zfish   314 TLGFRIEGIKRGE-TCNTDFKKTRSKEDVTQVFKDFIEGNKNIINSYITRLEEIKRALKASEFFK 377

  Fly   588 THEVIGSSLLFVHDQT-HASIWLIDFAKTVELPPQLRIDHYSAWKVGNHEDGYLIGINNLIDIFV 651
            .||||||||||:||.| .|.:|||||.||..||....:|||..|:.||.|||||.|::||:....
Zfish   378 KHEVIGSSLLFIHDHTERAEVWLIDFGKTTALPDGQYLDHYRPWEEGNREDGYLWGLDNLLQTLS 442

  Fly   652 EL 653
            .|
Zfish   443 SL 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IP3K2	NP_572873.2	IPK	441..650	CDD:281727	120/209 (57%)
itpka	NP_001313405.1	IPK	232..442	CDD:281727	120/210 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1715
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2443
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D410791at33208
OrthoFinder	1	1.000	-	-		FOG0001484
OrthoInspector	1	1.000	-	-		otm24950
orthoMCL	1	0.900	-	-		OOG6_103318
Panther	1	1.100	-	-	O	PTHR12400
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.970