Protein Alignment IP3K2 and Itpkb

DIOPT Version :9

• Sequence 1: NP_572873.2
• Gene: IP3K2 / 32285
• FlyBaseID: FBgn0283680
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_001074644.1
• Gene: Itpkb / 320404
• MGIID: 109235
• Length: 942
• Species: Mus musculus
• Alignment Length: 687
• Identity: 259/687 - (37%)
• Similarity: 346/687 - (50%)
• Gaps: 117/687 - (17%)

  Fly    21 PGATASNSDEGCNVTGGGLSPYSSDNE--------DNSLSPRQRKMKVTRCASSDSALGLDVDD- 76
            ||..::..:.||.:  ||:.|:.:..|        :...:|...:   |........:|..:..
Mouse   312 PGHDSALMETGCEL--GGMRPWEAQMERRGQFLGKETGSTPEPVR---THMREPPGRVGRGIHSV 371

  Fly    77 GGMD------VPLPPQRRMTLTVTDLPLRPALLPLAEP--TALP-DSPLTSPTGGGN--PSVGVP 130
            ||..      :..|.:|.:|...::        |..:|  :.|| |.....|..|||  |.:..|
Mouse   372 GGQGSWTPEVIKRPEERAVTAQSSE--------PSEDPRWSRLPVDLDSVGPEKGGNRIPGMRGP 428

  Fly   131 TKVLLEER------------VVAAPGSRRESTQSSYSELGVSGLPLG--VRYVRTPSVVVSDYSD 181
            .:.|..||            ..|.||:|.......|..: :..||.|  ...::.|..:..|
Mouse   429 QQTLDSEREGSPALGLLGGSQAAQPGARGVEEDVHYGRM-LEPLPPGEVTTKLKEPQCLPGD--- 489

  Fly   182 DITACGISMEEMEYFRLQRARGQRRCSLEAGHHSHSGGHGAHGHGGSGA----AGMSPGCGK--D 240
               ..|:..|....:         ..:||......:...|....|..|:    ....|.|.:  .
Mouse   490 ---RMGMQPESSIVW---------PSALEEAPLIWTRDTGVQSKGTWGSQLPDGDAHPSCQEMPP 542

  Fly   241 DGQSDVSAASSCSNLYYCGSTISAL------------DGG-ECIVNGVRVALARKSSTQSSSLSD 292
            |.:...|...:||     .|.|.|:            ||| |.|....|..|..:..:.||:.|.
Mouse   543 DQKDKASLKEACS-----PSNIPAIPAVIITDMGAQEDGGLEEIQGSPRGPLPLRKLSSSSASST 602

  Fly   293 EEEEEEDDDEDRDEQDRDEDDRDAEEMLQEDYERGDRERERERQISELMAATQLGDRQRDRSKKS 357
            ......||.|:                        |...:.||.:....|.....|:|:.|..||
Mouse   603 GFSSSYDDSEE------------------------DISSDPERTLDPNSAFLHTLDQQKPRVSKS 643

  Fly   358 SGWRKIRNIVQWTPFFQTYKKQRYPWVQLAGHQGNFKAGPEPGTVLKKLCPKEEECFQILMHDLL 422
              ||||:|:|||:||..::|| :|||:|||||.|:|||... |.:|||.|..|:.|...||.|:|
Mouse   644 --WRKIKNMVQWSPFVMSFKK-KYPWIQLAGHAGSFKAAAN-GRILKKHCESEQRCLDRLMADVL 704

  Fly   423 RPYVPVYKGQVTSEDGELYLQLQDLLSDYVQPCVMDCKVGVRTYLEEELSKAKEKPKLRKDMYDK 487
            ||:||.|.|.|. :|||.|.|:.|||:|:..|||||||:||||||||||:||::||.||||||.|
Mouse   705 RPFVPAYHGDVV-KDGERYNQMDDLLADFDSPCVMDCKMGVRTYLEEELTKARKKPSLRKDMYQK 768

  Fly   488 MIQIDSHAPTAEEHAAKAVTKPRYMVWRETISSTATLGFRIEGIKKSDGTSSKDFKTTKSREQIK 552
            |:::|..|||.||.|.:||||||||.||||||||||||||||||||.||:.::|||.||:|||:.
Mouse   769 MVEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGSVNRDFKKTKTREQVT 833

  Fly   553 LAFLEFLSGHPHILPRYIQRLRAIRATLAVSEFFQTHEVIGSSLLFVHD-QTHASIWLIDFAKTV 616
            .||.||..|:.:||..|..||:||||||.:|.||:.||||||||||:|| :..|.:|:|||.||.
Mouse   834 EAFREFTKGNQNILIAYRDRLKAIRATLEISPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTT 898

  Fly   617 ELPPQLRIDHYSAWKVGNHEDGYLIGINNLIDIFVEL 653
            .||....:.|...|:.||.|||||.|::|||||..|:
Mouse   899 PLPEGQTLQHDVPWQEGNREDGYLSGLDNLIDILTEM 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IP3K2	NP_572873.2	IPK	441..650	CDD:281727	134/209 (64%)
Itpkb	NP_001074644.1	PHA03307	24..>317	CDD:223039	2/4 (50%)
		IPK	722..933	CDD:367650	135/210 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1615
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1672
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001484
OrthoInspector	1	1.000	-	-		otm43828
orthoMCL	1	0.900	-	-		OOG6_103318
Panther	1	1.100	-	-	LDO	PTHR12400
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10451
SonicParanoid	1	1.000	-	-		X1215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.940