DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IP3K2 and Itpkc

DIOPT Version :9

Sequence 1:	NP_572873.2	Gene:	IP3K2 / 32285	FlyBaseID:	FBgn0283680	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_835195.1	Gene:	Itpkc / 308451	RGDID:	631336	Length:	678	Species:	Rattus norvegicus

Alignment Length:	705	Identity:	234/705 - (33%)
Similarity:	317/705 - (44%)	Gaps:	176/705 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PKTLPGATASNSDEGCNVTGGGL-SPYSSDNEDNSLSPRQRKMKVTRCASSDSALGLDVDDGGMD 80
            |:..|   ..:..|.|...|.|: |...|.|::...|..|...|::...:.....|...|....|
  Rat    85 PQAEP---CGDEHEECEAAGLGVASEKPSQNKELDGSNLQTHPKLSSPLAEMEMAGSWTDGFRTD 146

  Fly    81 VPLP-----PQRR---------------------MTLTVTDLPLRPALLPLAEPTALPDSP-LTS 118
            :..|     |:|.                     .||...|.|....|....:.:.|.:.| ..|
  Rat   147 LHRPDLQARPKRASLCTQPGFDESWTELDRSELWQTLPERDKPWVDHLRTHQDMSRLQNHPACPS 211

  Fly   119 PTGGGNPSVGVPTKVLLEERVVAAPGSRR-ESTQSSYSELGVSGLPLGVRYVRTPSVVVSDYSDD 182
            |    .||.|...|.|      :|.|||. ..|...:.|....|..:|      ||..
  Rat   212 P----EPSAGTSCKEL------SADGSRTPHDTDGFWIESQTDGSLIG------PSTQ------- 253

  Fly   183 ITAC------GISMEEMEYFRLQRARGQRRCSLEAGHHSHSGGHGAHGHGGSGAAGMSPGCGKDD 241
             |||      |.|.::.:...:|.                                     |.||
  Rat   254 -TACRQPANDGFSAQDTDGTLIQP-------------------------------------GTDD 280

  Fly   242 GQ--SDVSAASS-----------------CSNLYYCGS----------TISALDGGECIVNGVRV 277
            |.  ..|...|:                 ||:| .|.|          :.|...|.:.:....|:
  Rat   281 GPWVDSVLEKSNGDDPLMEPEPRDLVTNLCSHL-ECSSLCPVPRLIITSESPEPGAQPLGPQARI 344

  Fly   278 ALARKSSTQSSSLSDEEEEEEDDDEDRDEQDRDEDDRDAEEMLQEDYERGDRERERERQISELMA 342
                :..|...|.:...:|.|||.........|.:||..
  Rat   345 ----EGGTGGFSSASSFDESEDDLVAGGGGTSDPEDRSG-------------------------- 379

  Fly   343 ATQLGDRQRDRSKKSSGWRKIRNIVQWTPFFQTYKKQRYPWVQLAGHQGNFKAGPEPGTVLKKLC 407
                          |..|:|::.:::::||..::.|..||||||:||.|||:|| |.|.:||:.|
  Rat   380 --------------SKPWKKLKTVLKYSPFVVSFHKHYYPWVQLSGHAGNFQAG-EDGRILKRFC 429

  Fly   408 PKEEECFQILMHDLLRPYVPVYKGQVTSEDGELYLQLQDLLSDYVQPCVMDCKVGVRTYLEEELS 472
            ..|:...::||.|.|||:||.|.|.| ..||:.:.|::|||:|:..|.:||||:|.||||||||.
  Rat   430 QCEQRSLELLMGDPLRPFVPTYYGMV-QRDGQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELV 493

  Fly   473 KAKEKPKLRKDMYDKMIQIDSHAPTAEEHAAKAVTKPRYMVWRETISSTATLGFRIEGIKKSDGT 537
            ||:|:||.|||||:||:.:|..|||.||||..||||||||.||||:|||:|||||||||||:|||
  Rat   494 KARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETLSSTSTLGFRIEGIKKADGT 558

  Fly   538 SSKDFKTTKSREQIKLAFLEFLSGHPHILPRYIQRLRAIRATLAVSEFFQTHEVIGSSLLFVHDQ 602
            .:.:||.|::.||:.....:|::|...||.:|:.||..:|.||..|.||:||||:|||||||||.
  Rat   559 CNTNFKKTQALEQVTKVLEDFVNGDVGILRKYVARLEDLRDTLENSPFFKTHEVVGSSLLFVHDH 623

  Fly   603 TH-ASIWLIDFAKTVELPPQLRIDHYSAWKVGNHEDGYLIGINNLIDIFVELQAS 656
            |. |.:|:|||.|||.||....:.|...|..||.|||||.|::|||.:...|..|
  Rat   624 TGLAKVWMIDFGKTVALPDHQMLSHRLPWAEGNREDGYLWGLDNLICLLQGLAQS 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IP3K2	NP_572873.2	IPK	441..650	CDD:281727	123/209 (59%)
Itpkc	NP_835195.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..125		11/42 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..300		31/159 (19%)
		Nuclear export signal	318..326		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..381		12/95 (13%)
		IPK	462..673	CDD:281727	123/210 (59%)
		Substrate binding. /evidence=ECO:0000250	502..508		5/5 (100%)
		Calmodulin-binding. /evidence=ECO:0000250	504..512		5/7 (71%)
		Substrate binding. /evidence=ECO:0000250	529..536		5/6 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1552
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2213
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D410791at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45912
orthoMCL	1	0.900	-	-		OOG6_103318
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870