DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IP3K2 and Itpkc

DIOPT Version :9

Sequence 1:	NP_572873.2	Gene:	IP3K2 / 32285	FlyBaseID:	FBgn0283680	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_853624.1	Gene:	Itpkc / 233011	MGIID:	2442554	Length:	678	Species:	Mus musculus

Alignment Length:	732	Identity:	242/732 - (33%)
Similarity:	329/732 - (44%)	Gaps:	198/732 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QQQQLSNEG-----EPKTLP-GATASNSDEG---CNVTGGGLSPYSSDNEDNSLSPRQRKMKVTR 62
            ::..|.:|.     ||...| |..|.:..:|   |...|..::         |..|||.|
Mouse    63 EESSLHSEAERTDLEPAPCPNGPQAESCGDGHAECEAAGLVVA---------SEKPRQNK----- 113

  Fly    63 CASSDSALGLDVDDGGMDVPLPPQR-----------------RMTLTVTDLPLRPALLPL-AEP- 108
                      ::|  |.::...|:|                 |..|..:||..||....| .:|
Mouse   114 ----------ELD--GSNLQTHPRRNSPLVEMEMAGSWTDGFRTDLHRSDLQSRPKRASLCTQPG 166

  Fly   109 -----TALPDSPL--TSPTGGGNPSV-------GVPTKVLLEERVVAAPGSRRESTQSSYSELGV 159
                 |.|..|.:  |.|.....|.|       ||  ..|....|..:|.|..::
Mouse   167 FDESWTELDRSDMWQTLPERDNKPRVDNLRTHHGV--SKLQTHPVCLSPESSADN---------- 219

  Fly   160 SGLPLGVRYVRTP----SVVVSDYSDDI-------TAC------GISMEEMEYFRLQRARGQRRC 207
            ||..|.....|||    ...:...:||.       |||      |.|.::.|
Mouse   220 SGKELSADASRTPHDTDGFWIESQTDDSLKGPSTQTACRQPGSDGFSSKDTE------------- 271

  Fly   208 SLEAGHHSHSGGHGAHGHGGSGAAGMSPGCGKDDGQSDVSAASSCSNLYYCGSTISALDGGECIV 272
                                  :|...||   .||..|.|.....:.    ...:...:.||.:.
Mouse   272 ----------------------SALTQPG---TDGLRDDSVLGESNG----NDPLDLSEPGELVT 307

  Fly   273 NGVRVALARKSSTQSSSL-----------SDEEEEEEDDDEDRDEQ-----------DRDEDDRD 315
            |       ..|..:.|||           :.|.|.:....:.|.|.           |..|||
Mouse   308 N-------LCSHLECSSLCPVPRLIITPETPEPEAQPVGPQSRIEGGTGGFSSASSFDESEDD-- 363

  Fly   316 AEEMLQEDYERGDRERERERQISELMAATQLGDRQRDRSKKSSGWRKIRNIVQWTPFFQTYKKQR 380
                                    |:|.........||: .|..|:|::.:::::||..::.|..
Mouse   364 ------------------------LVAGGGGTSDPEDRA-GSKPWKKLKTVLKYSPFVVSFHKHY 403

  Fly   381 YPWVQLAGHQGNFKAGPEPGTVLKKLCPKEEECFQILMHDLLRPYVPVYKGQVTSEDGELYLQLQ 445
            ||||||:||.|||:|| |.|.:||:.|..|:...::||.|.|||:||.|.|.| ..||:.:.|::
Mouse   404 YPWVQLSGHAGNFQAG-EDGRILKRFCQCEQRSLELLMGDPLRPFVPAYYGMV-QRDGQAFNQME 466

  Fly   446 DLLSDYVQPCVMDCKVGVRTYLEEELSKAKEKPKLRKDMYDKMIQIDSHAPTAEEHAAKAVTKPR 510
            |||:|:..|.:||||:|.||||||||.||:|:||.|||||:||:.:|..|||.||||..|:||||
Mouse   467 DLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAITKPR 531

  Fly   511 YMVWRETISSTATLGFRIEGIKKSDGTSSKDFKTTKSREQIKLAFLEFLSGHPHILPRYIQRLRA 575
            ||.||||:|||:|||||||||||:|||.:.:||.|::.||:.....:|::|...||.:|:.||..
Mouse   532 YMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDLGILRKYVARLED 596

  Fly   576 IRATLAVSEFFQTHEVIGSSLLFVHDQTH-ASIWLIDFAKTVELPPQLRIDHYSAWKVGNHEDGY 639
            :|.||..|.||:||||:|||||||||.|. |.:|:|||.|||.||....:.|...|..||.||||
Mouse   597 LRETLENSPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWTEGNREDGY 661

  Fly   640 LIGINNLIDIFVELQAS 656
            |.|::|||.:...|..|
Mouse   662 LWGLDNLICLLQGLAQS 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IP3K2	NP_572873.2	IPK	441..650	CDD:281727	122/209 (58%)
Itpkc	NP_853624.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..128		19/90 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..300		40/202 (20%)
		Nuclear export signal. /evidence=ECO:0000250	318..326		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..380		12/78 (15%)
		IPK	462..673	CDD:281727	122/210 (58%)
		Substrate binding. /evidence=ECO:0000250	502..508		5/5 (100%)
		Calmodulin-binding. /evidence=ECO:0000250	504..512		5/7 (71%)
		Substrate binding. /evidence=ECO:0000250	529..536		5/6 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1615
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	348	1.000	Inparanoid score	I2282
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D410791at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43828
orthoMCL	1	0.900	-	-		OOG6_103318
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.870