DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IP3K2 and Itpka

DIOPT Version :9

Sequence 1:	NP_572873.2	Gene:	IP3K2 / 32285	FlyBaseID:	FBgn0283680	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_666237.1	Gene:	Itpka / 228550	MGIID:	1333822	Length:	459	Species:	Mus musculus

Alignment Length:	566	Identity:	220/566 - (38%)
Similarity:	281/566 - (49%)	Gaps:	135/566 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 LPDSP--LTSPTGGGNPSVGV---------PTKVLLEERVVA-----------APGSRRESTQSS 153
            ||..|  :..|.|.|..|.|:         ..::|.|.|..|           |.|::|...|..
Mouse     3 LPGRPTGMARPRGAGPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVP 67

  Fly   154 YSELGVSGLPLGVRYVRTPSVVVSDYSDDITACGISMEEMEYFRLQRARGQRRCSLEAGHHSHSG 218
                  :|||........|.:.|:. .:|:|..
Mouse    68 ------NGLPRAAPAPVIPQLTVTS-EEDVTPA-------------------------------- 93

  Fly   219 GHGAHGHGGSGAAGMSPGCGKDDGQSDVSAASSCSNLYYCGSTISALDGGECIVNGVRVALARKS 283
                           |||....:|....:|                   |..:....|::.:..|
Mouse    94 ---------------SPGPPDQEGNWLPAA-------------------GSHLQQPRRLSTSSLS 124

  Fly   284 STQSSSLSDEEEEEEDDDEDRDEQDRDEDDRDAEEMLQEDYERGDRERERERQISELMAATQLGD 348
            ||.||||.    |:.:||...|.:.|               .||:.:.|....:.:
Mouse   125 STGSSSLL----EDSEDDLLSDSESR---------------SRGNVQLETSEDVGQ--------- 161

  Fly   349 RQRDRSKKSSGWRKIRNIVQWTPFFQTYKKQRYPWVQLAGHQGNFKAGPEPGTVLKKLCPKEEEC 413
                    .|.|:|||.:|. .|....::| ||.|||||||.|:|||....|.:||:....|..|
Mouse   162 --------KSHWQKIRTMVN-LPVMSPFRK-RYSWVQLAGHTGSFKAAGTSGLILKRSSEPEHYC 216

  Fly   414 FQILMHDLLRPYVPVYKGQVTSEDGELYLQLQDLLSDYVQPCVMDCKVGVRTYLEEELSKAKEKP 478
            ...||.|:||..||.:.| :...|||.||||||||..:..|||:|||:||||||||||:||:|:|
Mouse   217 LVRLMADVLRGCVPAFHG-IVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERP 280

  Fly   479 KLRKDMYDKMIQIDSHAPTAEEHAAKAVTKPRYMVWRETISSTATLGFRIEGIKKSDGTSSKDFK 543
            |||||||.||:.:|..|||.||||.:||||||||.|||.|||:.|||||||||||:||:.|.|||
Mouse   281 KLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFK 345

  Fly   544 TTKSREQIKLAFLEFLSGHPHILPRYIQRLRAIRATLAVSEFFQTHEVIGSSLLFVHDQTH-ASI 607
            ||:||||:...|.||:.|...:|.||:.||:.||.||.:|:||:.|||||||||||||..| |.:
Mouse   346 TTRSREQVTRVFEEFMQGDAEVLRRYLNRLQQIRDTLEISDFFRRHEVIGSSLLFVHDHCHRAGV 410

  Fly   608 WLIDFAKTVELPPQLRIDHYSAWKVGNHEDGYLIGINNLIDIFVEL 653
            |||||.||..||....:||...|:.||.|||||:|::|||.|...|
Mouse   411 WLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IP3K2	NP_572873.2	IPK	441..650	CDD:281727	136/209 (65%)
Itpka	NP_666237.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		8/25 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..164		33/223 (15%)
		IPK	243..453	CDD:281727	136/209 (65%)
		Calmodulin-binding. /evidence=ECO:0000250	285..293		5/7 (71%)
		Substrate binding. /evidence=ECO:0000250	310..317		5/6 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1615
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	348	1.000	Inparanoid score	I2282
Isobase	1	0.950	-	0	Normalized mean entropy	S4475
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D410791at33208
OrthoFinder	1	1.000	-	-		FOG0001484
OrthoInspector	1	1.000	-	-		otm43828
orthoMCL	1	0.900	-	-		OOG6_103318
Panther	1	1.100	-	-	O	PTHR12400
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10451
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.950