Protein Alignment IP3K2 and Itpka

DIOPT Version :10

• Sequence 1: NP_572873.2
• Gene: IP3K2 / 32285
• FlyBaseID: FBgn0283680
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_666237.1
• Gene: Itpka / 228550
• MGIID: 1333822
• Length: 459
• Species: Mus musculus
• Alignment Length: 566
• Identity: 220/566 - (38%)
• Similarity: 281/566 - (49%)
• Gaps: 135/566 - (23%)

  Fly   111 LPDSP--LTSPTGGGNPSVGV---------PTKVLLEERVVA-----------APGSRRESTQSS 153
            ||..|  :..|.|.|..|.|:         ..::|.|.|..|           |.|::|...|..
Mouse     3 LPGRPTGMARPRGAGPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVP 67

  Fly   154 YSELGVSGLPLGVRYVRTPSVVVSDYSDDITACGISMEEMEYFRLQRARGQRRCSLEAGHHSHSG 218
                  :|||........|.:.|:. .:|:|..
Mouse    68 ------NGLPRAAPAPVIPQLTVTS-EEDVTPA-------------------------------- 93

  Fly   219 GHGAHGHGGSGAAGMSPGCGKDDGQSDVSAASSCSNLYYCGSTISALDGGECIVNGVRVALARKS 283
                           |||....:|....:|                   |..:....|::.:..|
Mouse    94 ---------------SPGPPDQEGNWLPAA-------------------GSHLQQPRRLSTSSLS 124

  Fly   284 STQSSSLSDEEEEEEDDDEDRDEQDRDEDDRDAEEMLQEDYERGDRERERERQISELMAATQLGD 348
            ||.||||.    |:.:||...|.:.|               .||:.:.|....:.:
Mouse   125 STGSSSLL----EDSEDDLLSDSESR---------------SRGNVQLETSEDVGQ--------- 161

  Fly   349 RQRDRSKKSSGWRKIRNIVQWTPFFQTYKKQRYPWVQLAGHQGNFKAGPEPGTVLKKLCPKEEEC 413
                    .|.|:|||.:|. .|....::| ||.|||||||.|:|||....|.:||:....|..|
Mouse   162 --------KSHWQKIRTMVN-LPVMSPFRK-RYSWVQLAGHTGSFKAAGTSGLILKRSSEPEHYC 216

  Fly   414 FQILMHDLLRPYVPVYKGQVTSEDGELYLQLQDLLSDYVQPCVMDCKVGVRTYLEEELSKAKEKP 478
            ...||.|:||..||.:.| :...|||.||||||||..:..|||:|||:||||||||||:||:|:|
Mouse   217 LVRLMADVLRGCVPAFHG-IVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERP 280

  Fly   479 KLRKDMYDKMIQIDSHAPTAEEHAAKAVTKPRYMVWRETISSTATLGFRIEGIKKSDGTSSKDFK 543
            |||||||.||:.:|..|||.||||.:||||||||.|||.|||:.|||||||||||:||:.|.|||
Mouse   281 KLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFK 345

  Fly   544 TTKSREQIKLAFLEFLSGHPHILPRYIQRLRAIRATLAVSEFFQTHEVIGSSLLFVHDQTH-ASI 607
            ||:||||:...|.||:.|...:|.||:.||:.||.||.:|:||:.|||||||||||||..| |.:
Mouse   346 TTRSREQVTRVFEEFMQGDAEVLRRYLNRLQQIRDTLEISDFFRRHEVIGSSLLFVHDHCHRAGV 410

  Fly   608 WLIDFAKTVELPPQLRIDHYSAWKVGNHEDGYLIGINNLIDIFVEL 653
            |||||.||..||....:||...|:.||.|||||:|::|||.|...|
Mouse   411 WLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASL 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IP3K2	NP_572873.2	IPK	441..650	CDD:397715	136/209 (65%)
Itpka	NP_666237.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		8/25 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..164		33/223 (15%)
		IPK	243..453	CDD:397715	136/209 (65%)
		Calmodulin-binding. /evidence=ECO:0000250	285..293		5/7 (71%)