| Sequence 1: | NP_001259507.1 | Gene: | HDAC4 / 32278 | FlyBaseID: | FBgn0041210 | Length: | 1269 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | XP_011510519.1 | Gene: | HDAC4 / 9759 | HGNCID: | 14063 | Length: | 1113 | Species: | Homo sapiens |
| Alignment Length: | 1342 | Identity: | 461/1342 - (34%) |
|---|---|---|---|
| Similarity: | 661/1342 - (49%) | Gaps: | 365/1342 - (27%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 10 IHDLPSEAGSDERL-LHITPATLTLDFK---------PHPAV---DIDQQIMELKKSQELQKQRL 61
Fly 62 INSFQEQSKQMELEHKLQL-EHKYQKQPTNKRFSLELIVIIQFAVNSHGAFQELRNESMVTAAAA 125
Fly 126 AVAQEQHRQQL--HQQQ-QQHQQQQQ-QQQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILN 186
Fly 187 CFILSRKSQAAAS--NGTTTTSPYRNRGVVKSSS--GESLPAGTVTSAHPYKIPQPPPSLLKYES 247
Fly 248 --DFPLRKTASEPNL-LKIRLKQSVIERKARIGGPAGARRHERLLQAAQRRQQKNSVLTNCNSTP 309
Fly 310 DSGPNSP--------------------PSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQPGQRS 354
Fly 355 SINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGC 419
Fly 420 GQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQ-QPSPVVRSASATSTSSSQASLVGDVAPPQAHA 483
Fly 484 ASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHG 548
Fly 549 HGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAV--------- 604
Fly 605 ------------QLNVV-----------QTHYENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAA 646
Fly 647 AAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYR 711
Fly 712 APHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRPLSRTLSSPLVPLGPHGL 776
Fly 777 SQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHK--VTT 839
Fly 840 GLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAH 904
Fly 905 AMLFGSNQCQLSRPKLEN-----TLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLA 964
Fly 965 LKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNG 1029
Fly 1030 TQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAF 1094
Fly 1095 RTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGY 1159
Fly 1160 DLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLS 1224
Fly 1225 ALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQD 1266 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HDAC4 | NP_001259507.1 | iSH2_PI3K_IA_R | 43..>87 | CDD:304922 | 18/44 (41%) |
| HDAC_classIIa | 837..1211 | CDD:212544 | 230/378 (61%) | ||
| HDAC4 | XP_011510519.1 | ClassIIa_HDAC4_Gln-rich-N | <115..176 | CDD:197398 | 11/63 (17%) |
| HDAC4 | 678..1086 | CDD:212530 | 173/414 (42%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 448 | 1.000 | Domainoid score | I516 |
| eggNOG | 1 | 0.900 | - | - | E1_COG0123 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 610 | 1.000 | Inparanoid score | I921 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG46994 | |
| OrthoDB | 1 | 1.010 | - | - | D119187at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001001 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41987 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100220 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR48252 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2991 |
| SonicParanoid | 1 | 1.000 | - | - | X933 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 14 | 13.870 | |||||