Protein Alignment HDAC4 and HDAC4

DIOPT Version :10

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_011510519.1
• Gene: HDAC4 / 9759
• HGNCID: 14063
• Length: 1113
• Species: Homo sapiens
• Alignment Length: 1342
• Identity: 461/1342 - (34%)
• Similarity: 661/1342 - (49%)
• Gaps: 365/1342 - (27%)

  Fly    10 IHDLPSEAGSDERL-LHITPATLTLDFK---------PHPAV---DIDQQIMELKKSQELQKQRL 61
            ::.:||.......| |.:.|:.:.:|.:         ..||:   .:.|:::.||:.|::|:|.|
Human    49 VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQIL 113

  Fly    62 INSFQEQSKQMELEHKLQL-EHKYQKQPTNKRFSLELIVIIQFAVNSHGAFQELRNESMVTAAAA 125
            |..||.|.:|:..:|:.|| ||..|:|        |::.:
Human   114 IAEFQRQHEQLSRQHEAQLHEHIKQQQ--------EMLAM------------------------- 145

  Fly   126 AVAQEQHRQQL--HQQQ-QQHQQQQQ-QQQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILN 186
                 :|:|:|  ||:: ::|:|:|: ::||::|:.||......|.:     ||.||.|||..|.
Human   146 -----KHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKE-----SAVASTEVKMKLQ 200

  Fly   187 CFILSRKSQAAAS--NGTTTTSPYRNRGVVKSSS--GESLPAGTVTSAHPYKIPQPPPSLLKYES 247
            .|:|::|...|..  |...::.|....|..:.||  ..|.|...|::::.:      |.|..|::
Human   201 EFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNH------PVLGMYDA 259

  Fly   248 --DFPLRKTASEPNL-LKIRLKQSVIERKARIGGPAGARRHERLLQAAQRRQQKNSVLTNCNSTP 309
              ||||||||||||| |:.||||.|.||::   .|. .||.:..:..|.:::..:...:.|:|.|
Human   260 KDDFPLRKTASEPNLKLRSRLKQKVAERRS---SPL-LRRKDGPVVTALKKRPLDVTDSACSSAP 320

  Fly   310 DSGPNSP--------------------PSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQPGQRS 354
            .|||:||                    |:..:||..:|...||  :||
Human   321 GSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGS--AAP----------------- 366

  Fly   355 SINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGC 419
                |||::|||||||:||.|....||....|.:|:.......|.:
Human   367 ----LPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQR------------------- 408

  Fly   420 GQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQ-QPSPVVRSASATSTSSSQASLVGDVAPPQAHA 483
                                |::.|.|.:.|. ..||:.|...|..:...|..::.:..|.||..
Human   409 --------------------LSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPL 453

  Fly   484 ASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHG 548
            .      :..|:..||::.     |||.::..|
Human   454 V------TDWYLSGLGALP-----LHAQSLVGA-------------------------------- 475

  Fly   549 HGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAV--------- 604
                                |.....:|..:| |||||||||||||.....|...|
Human   476 --------------------DRVSPSIHKLRQ-HRPLGRTQSAPLPQNAQALQHLVIQQQHQQFL 519

  Fly   605 ------------QLNVV-----------QTHYENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAA 646
                        |:|.:           ::|.|  |.|.:..|||.:   :.:..|.|......|
Human   520 EKHKQQFQQQQLQMNKIIPKPSEPARQPESHPE--ETEEELREHQAL---LDEPYLDRLPGQKEA 579

  Fly   647 AAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYR 711
            .|.|||.|.:|   ..|.|:..||         ||:.|       ...|..|.
Human   580 HAQAGVQVKQE---PIESDEEEAE---------PPREV-------EPGQRQPS------------ 613

  Fly   712 APHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRPLSRTLSSPLVPLGPHGL 776
                                :||.|  .|:|.|||:|:.   ...:|....::.:..:|
Human   614 --------------------EQELL--FRQQALLLEQQR---IHQLRNYQASMEAAGIP------ 647

  Fly   777 SQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHK--VTT 839
              :...|.:|...|.||.|....||::.                           .||.|  .||
Human   648 --VSFGGHRPLSRAQSSPASATFPVSVQ---------------------------EPPTKPRFTT 683

  Fly   840 GLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAH 904
            ||.||.|||||.|.||.::.||||:||:||:|:||.||.|..:|:.:|.||||.|||||||:|||
Human   684 GLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAH 748

  Fly   905 AMLFGSNQCQLSRPKLEN-----TLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLA 964
            .:|:|:|  .|:|.||::     :|::.||||.|||:|||.||.|||.|:|.|||:|.|||::|.
Human   749 TLLYGTN--PLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELV 811

  Fly   965 LKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNG 1029
            .|.|.|:|:||||||||||||||.:..||||:|||:|:|||||:||: .|.:|||||||||||||
Human   812 FKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRL-SVSKILIVDWDVHHGNG 875

  Fly  1030 TQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAF 1094
            ||||||..|.:||:|:||:||||||||:|.|.|.|:|.|:|||||::::|.|:||:|||||:|||
Human   876 TQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF 940

  Fly  1095 RTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGY 1159
            ||||||||..|.||:|||||||||..|||.|||||::|..|||::|::|:.||.|::|||||||:
Human   941 RTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGH 1005

  Fly  1160 DLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLS 1224
            ||.||||:::.||.||||:...|:.:..|::.|..||:.:::|.:.|...:|.|::....|.|.|
Human  1006 DLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRS 1070

  Fly  1225 ALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQD 1266
            .:|....|::|:||:.|||.||: .:.....|.| ||||:::
Human  1071 LIEAQTCENEEAETVTAMASLSV-GVKPAEKRPD-EEPMEEE 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	ClassIIa_HDAC_Gln-rich-N	43..>87	CDD:421006	18/44 (41%)
		HDAC_classIIa	837..1211	CDD:212544	230/378 (61%)
HDAC4	XP_011510519.1	ClassIIa_HDAC4_Gln-rich-N	<115..176	CDD:197398	11/63 (17%)
		HDAC4	678..1086	CDD:212530	173/414 (42%)