DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and HDAC9

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_848512.1	Gene:	HDAC9 / 9734	HGNCID:	14065	Length:	1069	Species:	Homo sapiens

Alignment Length:	1298	Identity:	444/1298 - (34%)
Similarity:	658/1298 - (50%)	Gaps:	309/1298 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ITPATLTLDFK-PHPAVD-------IDQQIMELKKSQELQKQRLINSFQEQSKQMELEHKLQLEH 82
            |:|..|..|.: ..|.||       :.|:::.:::.|::|||.||..||:|.:.:..:|:.||:.
Human    21 ISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQE 85

  Fly    83 KYQKQPTNKRFSLELIVIIQFAVNSHGAFQELRNESMVTAAAAAVAQEQHRQQLHQQQQQHQQQQ 147
            ..:.|                        |||          .|:.|:|...:..|:.:|.:|:|
Human    86 HIKLQ------------------------QEL----------LAIKQQQELLEKEQKLEQQRQEQ 116

  Fly   148 QQQQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILNCFILSRKSQAAASNGTTTTSPYRNRG 212
            :.::|:::||....||:|..:.:    |.||.||||.|..|:||:    :|:..|.|..
Human   117 EVERHRREQQLPPLRGKDRGRER----AVASTEVKQKLQEFLLSK----SATKDTPTNG------ 167

  Fly   213 VVKSSSGESLPAGTVTSAHPYKIPQPPPSL------LKY--------ESDFPLRKTASEPNL-LK 262
              |:.|....|....|:||...:.|..|.|      .||        :.||||||||||||| ::
Human   168 --KNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVR 230

  Fly   263 IRLKQSVIERKARIGGPAGARRHERLLQAAQRRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVV 327
            .||||.|.||::   .|...|:...::.:.::|..:.:..:..:|:|.|||:||.:
Human   231 SRLKQKVAERRS---SPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNN--------- 283

  Fly   328 GSRGSPTSAPIQEENE--------EGSQYQPGQR-----SSINDLPLFSSPSLPNISLGRPHLPN 379
            |..||.|      |||        ...|....||     .|:|.|.|::|||||||:||.|.:|
Human   284 GPTGSVT------ENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVP- 341

  Fly   380 SAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQPGYYNPLGMAFVGRQPAPLAMIP 444
                 :|:||..:.:.:.:.:.|           ..:.|...||.|.              ..||
Human   342 -----SQLNASNSLKEKQKCETQ-----------TLRQGVPLPGQYG--------------GSIP 376

  Fly   445 ATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQAHAA--STILPSSSSYMQQLGSVAGSGVN 507
            |                  |:|....:|.|. .|..:|.|  ..:|.......|:| .||| ||.
Human   377 A------------------SSSHPHVTLEGK-PPNSSHQALLQHLLLKEQMRQQKL-LVAG-GVP 420

  Fly   508 LHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQV 572
            ||..:..|.....:                      |...|             .|.:|
Human   421 LHPQSPLATKERIS----------------------PGIRG-------------THKLP------ 444

  Fly   573 AQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQV-VNQKVRQTV 636
                    .||||.||||||||     .:...||.:.|.|.:..|.::| |:.|: :|:.:.:::
Human   445 --------RHRPLNRTQSAPLP-----QSTLAQLVIQQQHQQFLEKQKQ-YQQQIHMNKLLSKSI 495

  Fly   637 --LTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPE 699
              |.:.|           |.:.||:.:.:.|.:..|     |:
Human   496 EQLKQPG-----------SHLEEAEEELQGDQAMQE-----DR---------------------- 522

  Fly   700 ALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELA---KSLMRPL- 760
               |.::..:.|:..:|..:........:|::::.....:..|:..::..|:.|   :..:.|.
Human   523 ---APSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTH 584

  Fly   761 SRTLS---SPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQL 822
            :|.||   :||..:|..||.:           ....|..|..|....|||           .:..
Human   585 TRALSVRQAPLAAVGMDGLEK-----------HRLVSRTHSSPAASVLPH-----------PAMD 627

  Fly   823 RNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLR 887
            |..||.::        ||:|||||||||.|:||::..||||:||:||:|:||.||.|:.:|:|::
Human   628 RPLQPGSA--------TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQ 684

  Fly   888 ARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTL------SASFVRLSCGGLGVDLDTTWNE 946
            .|||:.||:|.||:|.|::|:|:|  .|...||:..:      ...|..|.|||||||.||.|||
Human   685 GRKASLEEIQLVHSEHHSLLYGTN--PLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNE 747

  Fly   947 HHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRM 1011
            .|::.|||||.||||:||.|.|.|:|:||||||||||||||.:.|||||||||:||.||.||.::
Human   748 LHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQL 812

  Fly  1012 PEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNIS 1076
             .:.:|||||.|||||||||||||..|.|||:|:||:|:||||||:|.|.|.|:|.|.|:|:||:
Human   813 -NISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIA 876

  Fly  1077 WSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR 1141
            |:|.|:||:||.||:.||||:|.|:|:.|:||:||||:||||..||..|||||.|:..|||.:|:
Human   877 WTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTK 941

  Fly  1142 ELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAI 1206
            :|:.||:|:||||||||:||.||||:::.||.||||:...|:|:..|.:.|..||:.:|||.|.|
Human   942 QLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEI 1006

  Fly  1207 QQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSE---EPMDQD 1266
            |..:|..|||:....| .||...::: :|:||::|:|.|:: .:.:..:::||.   |||:::
Human  1007 QSKYWKSVRMVAVPRG-CALAGAQLQ-EETETVSALASLTV-DVEQPFAQEDSRTAGEPMEEE 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922	13/43 (30%)
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	222/379 (59%)
HDAC9	NP_848512.1	Interaction with CTBP1. /evidence=ECO:0000250	23..27		1/3 (33%)
		ClassIIa_HDAC9_Gln-rich-N	38..127	CDD:197399	27/122 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..142		9/32 (28%)
		Interaction with MEF2. /evidence=ECO:0000250	139..157		10/21 (48%)
		Interaction with MAPK10. /evidence=ECO:0000250	178..346		64/191 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..252		27/68 (40%)
		Interaction with ETV6. /evidence=ECO:0000269\|PubMed:12590135	221..264		17/45 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..307		15/56 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..539		11/82 (13%)
		HDAC_classIIa	634..1011	CDD:212544	222/387 (57%)
		Histone deacetylase	634..981		210/357 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153107
Domainoid	1	1.000	448	1.000	Domainoid score	I516
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	610	1.000	Inparanoid score	I921
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46994
OrthoDB	1	1.010	-	-		D119187at33208
OrthoFinder	1	1.000	-	-		FOG0001001
OrthoInspector	1	1.000	-	-		otm41987
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X933
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770