Protein Alignment HDAC4 and HDAC3

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: NP_001341968.1
• Gene: HDAC3 / 8841
• HGNCID: 4854
• Length: 434
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 107/465 - (23%)
• Similarity: 188/465 - (40%)
• Gaps: 98/465 - (21%)

  Fly   838 TTGLAYDPLMLKHSCICGD---NAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTV 899
            |....|||.:       |:   .|.||....||....:.:....|.|:....:..:|:|.::...
Human     4 TVAYFYDPDV-------GNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRF 61

  Fly   900 HTEAHAMLFGSNQCQLSRPKLENTLSASFVR-LSCGGLGVDLDT-----TWNEHHTATAARMAA- 957
            |:|.:....         .::..|....|.: |:...:|.|...     .:...:|..:.:.|.
Human    62 HSEDYIDFL---------QRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQ 117

  Fly   958 --GCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIV 1020
              ..:.|:|:..|.|            .|||:...|.|||:.|.|.|....|.:..|   |:|.:
Human   118 LNNKICDIAINWAGG------------LHHAKKFEASGFCYVNDIVIGILELLKYHP---RVLYI 167

  Fly  1021 DWDVHHGNGTQQAFYQSPDILYLSIHRHDDGN-FFPGTGGPTECGSGAGLGFNVNISWSGALNPP 1084
            |.|:|||:|.|:|||.:..::.:|.|::  || ||||||...|.|:.:|..:.:|:    .|...
Human   168 DIDIHHGDGVQEAFYLTDRVMTVSFHKY--GNYFFPGTGDMYEVGAESGRYYCLNV----PLRDG 226

  Fly  1085 LGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------EL 1143
            :.|..|...|:.|:..:...:.|..:::..|.|:       ||...:  .||....|      |.
Human   227 IDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADS-------LGCDRL--GCFNLSIRGHGECVEY 282

  Fly  1144 LQLANGKVVLALEGGYDL--AAICDSAQECVRALLGDPAA--------------------PIAKA 1186
            ::..|..:::...|||.:  .|.|.:.:   .:||.:.|.                    |....
Human   283 VKSFNIPLLVLGGGGYTVRNVARCWTYE---TSLLVEEAISEELPYSEYFEYFAPDFTLHPDVST 344

  Fly  1187 ELERPPCQNAINTLQKTIAIQQTHWPCVRMLEH--TVGLSALETLKVEHDESETINAMAGLSMQS 1249
            .:|.   ||:...|.:   |:||.:..::||.|  :|.:..:....:.:|.::..:|......::
Human   345 RIEN---QNSRQYLDQ---IRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEEN 403

  Fly  1250 MHRTLSRDDS 1259
            ..|:.|||.|
Human   404 YSRSGSRDFS 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
		HDAC_classIIa	837..1211	CDD:212544	96/413 (23%)
HDAC3	NP_001341968.1	HDAC3	3..383	CDD:212529	100/433 (23%)
		Histone deacetylase	3..316		87/360 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810