DRSC/TRiP Functional Genomics Resources

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Protein Alignment HDAC4 and HDA1

DIOPT Version :10

Sequence 1:NP_001259507.1 Gene:HDAC4 / 32278 FlyBaseID:FBgn0041210 Length:1269 Species:Drosophila melanogaster
Sequence 2:NP_014377.1 Gene:HDA1 / 855710 SGDID:S000004966 Length:706 Species:Saccharomyces cerevisiae


Alignment Length:477 Identity:169/477 - (35%)
Similarity:242/477 - (50%) Gaps:67/477 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   802 NLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQ----HPE 862
            :||...:..||::..:.       .|....||   :.|||.||..|..|:.|.....:    |||
Yeast    31 SLSTTSKSKRQVIVPVC-------MPKIHYSP---LKTGLCYDVRMRYHAKIFTSYFEYIDPHPE 85

  Fly   863 HSGRLQSVWARLNETDLVKRCD--------------RLRARKATQEELQTVHTEAHAMLFGSNQC 913
            ...|:..::..|.|..|:.  |              ::..|.||.||:..|||:.|.....|.: 
Yeast    86 DPRRIYRIYKILAENGLIN--DPTLSGVDDLGDLMLKIPVRAATSEEILEVHTKEHLEFIESTE- 147

  Fly   914 QLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAV 978
            ::||.:|.......             |:.:..:.:..:||:..|..|:......:|.::|..||
Yeast   148 KMSREELLKETEKG-------------DSVYFNNDSYASARLPCGGAIEACKAVVEGRVKNSLAV 199

  Fly   979 VRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPE-VRRILIVDWDVHHGNGTQQAFYQSPDILY 1042
            |||||||||...|.|||.|:::|:|||.:.:..|| ||||:|:|||:|||||||::|||...:||
Yeast   200 VRPPGHHAEPQAAGGFCLFSNVAVAAKNILKNYPESVRRIMILDWDIHHGNGTQKSFYQDDQVLY 264

  Fly  1043 LSIHRHDDGNFFPGT--GGPTECGSGAGLGFNVNISWS-GALNPPLGDAEYIAAFRTVVMPIARS 1104
            :|:||.:.|.::|||  |...:.|.|.|.|||.||:|. |.    :|||||:.||..||||:.|.
Yeast   265 VSLHRFEMGKYYPGTIQGQYDQTGEGKGEGFNCNITWPVGG----VGDAEYMWAFEQVVMPMGRE 325

  Fly  1105 FNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQ 1169
            |.||:|::|||||||.|.  .:|..||:|:|:|.||..|..||.|.:.:.|||||:|.||..||.
Yeast   326 FKPDLVIISSGFDAADGD--TIGQCHVTPSCYGHMTHMLKSLARGNLCVVLEGGYNLDAIARSAL 388

  Fly  1170 ECVRALLGDPAAPIAKAELERP---PCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKV 1231
            ...:.|:|:|     ..||..|   |....|..:.|.|.:|..:|.|.|......|.:..|.:  
Yeast   389 SVAKVLIGEP-----PDELPDPLSDPKPEVIEMIDKVIRLQSKYWNCFRRRHANSGCNFNEPI-- 446

  Fly  1232 EHDE--SETINAMAGLSMQSMH 1251
             :|.  |:.......:..|..|
Yeast   447 -NDSIISKNFPLQKAIRQQQQH 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC4NP_001259507.1 ClassIIa_HDAC_Gln-rich-N 43..>87 CDD:421006
HDAC_classIIa 837..1211 CDD:212544 153/398 (38%)
HDA1NP_014377.1 HDAC_Clr3 81..403 CDD:212542 138/348 (40%)
Arb2 457..698 CDD:401634 2/11 (18%)
Blue background indicates that the domain is not in the aligned region.

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