DRSC/TRiP Functional Genomics Resources

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Protein Alignment HDAC4 and HDA1

DIOPT Version :9

Sequence 1:NP_001259507.1 Gene:HDAC4 / 32278 FlyBaseID:FBgn0041210 Length:1269 Species:Drosophila melanogaster
Sequence 2:NP_014377.1 Gene:HDA1 / 855710 SGDID:S000004966 Length:706 Species:Saccharomyces cerevisiae


Alignment Length:479 Identity:169/479 - (35%)
Similarity:242/479 - (50%) Gaps:71/479 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   802 NLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQ----HPE 862
            :||...:..||::..:.       .|....||   :.|||.||..|..|:.|.....:    |||
Yeast    31 SLSTTSKSKRQVIVPVC-------MPKIHYSP---LKTGLCYDVRMRYHAKIFTSYFEYIDPHPE 85

  Fly   863 HSGRLQSVWARLNETDLVKRCD--------------RLRARKATQEELQTVHTEAHAMLFGSNQC 913
            ...|:..::..|.|..|:.  |              ::..|.||.||:..|||:.|.....|.: 
Yeast    86 DPRRIYRIYKILAENGLIN--DPTLSGVDDLGDLMLKIPVRAATSEEILEVHTKEHLEFIESTE- 147

  Fly   914 QLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAV 978
            ::||.:|.......             |:.:..:.:..:||:..|..|:......:|.::|..||
Yeast   148 KMSREELLKETEKG-------------DSVYFNNDSYASARLPCGGAIEACKAVVEGRVKNSLAV 199

  Fly   979 VRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPE-VRRILIVDWDVHHGNGTQQAFYQSPDILY 1042
            |||||||||...|.|||.|:::|:|||.:.:..|| ||||:|:|||:|||||||::|||...:||
Yeast   200 VRPPGHHAEPQAAGGFCLFSNVAVAAKNILKNYPESVRRIMILDWDIHHGNGTQKSFYQDDQVLY 264

  Fly  1043 LSIHRHDDGNFFPGT--GGPTECGSGAGLGFNVNISWSGALNPP---LGDAEYIAAFRTVVMPIA 1102
            :|:||.:.|.::|||  |...:.|.|.|.|||.||:|      |   :|||||:.||..||||:.
Yeast   265 VSLHRFEMGKYYPGTIQGQYDQTGEGKGEGFNCNITW------PVGGVGDAEYMWAFEQVVMPMG 323

  Fly  1103 RSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDS 1167
            |.|.||:|::|||||||.|.  .:|..||:|:|:|.||..|..||.|.:.:.|||||:|.||..|
Yeast   324 REFKPDLVIISSGFDAADGD--TIGQCHVTPSCYGHMTHMLKSLARGNLCVVLEGGYNLDAIARS 386

  Fly  1168 AQECVRALLGDPAAPIAKAELERP---PCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETL 1229
            |....:.|:|:|     ..||..|   |....|..:.|.|.:|..:|.|.|......|.:..|.:
Yeast   387 ALSVAKVLIGEP-----PDELPDPLSDPKPEVIEMIDKVIRLQSKYWNCFRRRHANSGCNFNEPI 446

  Fly  1230 KVEHDE--SETINAMAGLSMQSMH 1251
               :|.  |:.......:..|..|
Yeast   447 ---NDSIISKNFPLQKAIRQQQQH 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC4NP_001259507.1 iSH2_PI3K_IA_R 43..>87 CDD:304922
HDAC_classIIa 837..1211 CDD:212544 153/400 (38%)
HDA1NP_014377.1 HDAC_Clr3 81..403 CDD:212542 138/350 (39%)
Arb2 457..698 CDD:401634 2/11 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100220
Panther 1 1.100 - - O PTHR48252
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2991
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.840

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