DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and HOS2

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_011321.1	Gene:	HOS2 / 852681	SGDID:	S000003162	Length:	452	Species:	Saccharomyces cerevisiae

Alignment Length:	465	Identity:	118/465 - (25%)
Similarity:	175/465 - (37%)	Gaps:	117/465 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   859 QHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFG----SNQCQLSRPK 919
            :||....||......::...|.|..|....|.||::||...|:|.:.....    .|..:|.|..
Yeast    44 KHPMKPFRLMLTDHLVSSYGLHKIMDLYETRSATRDELLQFHSEDYVNFLSKVSPENANKLPRGT 108

  Fly   920 LENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPG- 983
            |||.           .:|.|.....|.:...|   :..|..:|...|....  ::..|:....|
Yeast   109 LENF-----------NIGDDCPIFQNLYDYTT---LYTGASLDATRKLINN--QSDIAINWSGGL 157

  Fly   984 HHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRH 1048
            |||:.|...|||:.|.|.::...|.:..|   |||.:|.|:|||:|.|:|||.:..:..||.|::
Yeast   158 HHAKKNSPSGFCYVNDIVLSILNLLRYHP---RILYIDIDLHHGDGVQEAFYTTDRVFTLSFHKY 219

  Fly  1049 DDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDA----EYIAAFRTVVMPIARSFNPDI 1109
             :|.||||||..||.|...|..|        |||.||.|.    .||..|:::|.|:..:|.|.:
Yeast   220 -NGEFFPGTGDLTEIGCDKGKHF--------ALNVPLEDGIDDDSYINLFKSIVDPLIMTFKPTL 275

  Fly  1110 VLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLAN--GKVVLALEGG-------------- 1158
            ::...|.| :.||.. ||.::::....|    |.::...  |..:|.:.||
Yeast   276 IVQQCGAD-SLGHDR-LGCFNLNIKAHG----ECVKFVKSFGLPMLVVGGGGYTPRNVSRLWTYE 334

  Fly  1159 --------------------------YDLAAICDSAQECVRALLGDPAAPIAKAELE--RPPCQN 1195
                                      |.|..:.|...|...          :|..||  |..|..
Yeast   335 TGILNDVLLPEDIPEDIPFRDSFGPDYSLYPMLDDLYENKN----------SKKLLEDIRIRCLE 389

  Fly  1196 AINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSE 1260
            .|..||..        |.|||....:....:..|..|.|:          .:|.|:.....|.|.
Yeast   390 NIRYLQGA--------PSVRMDAECIPTQDISALTEEEDK----------IIQEMNEETEADSSN 436

  Fly  1261 --EPMDQDET 1268
              |.|:::.:
Yeast   437 RLEEMEKENS 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	105/404 (26%)
HOS2	NP_011321.1	HDAC_Hos2	28..338	CDD:212540	93/327 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810