Protein Alignment HDAC4 and Hdac7

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_008764065.1
• Gene: Hdac7 / 84582
• RGDID: 619982
• Length: 975
• Species: Rattus norvegicus
• Alignment Length: 1212
• Identity: 407/1212 - (33%)
• Similarity: 552/1212 - (45%)
• Gaps: 360/1212 - (29%)

  Fly   131 QHRQQLHQ-------QQQQHQQQQQQ----------QQHQQQQQQQQARGRDGMKLKQNCSANAS 178
            ||.|:||:       ||||...:..:          |..||:|:.:|...:|    |...||.||
  Rat    45 QHPQRLHRHLFLAGLQQQQRSAEPMRLSMDPPLPELQGAQQEQELRQLLNKD----KSKRSAVAS 105

  Fly   179 PEVKQILNCFILSRKSQAAASNGTTTTS---PYR------NRGVVKSSSGESLPAGTVTSAHPYK 234
            ..|||.|...|| :|.|||.......:|   |||      ..|..:|.....||  .|.|
  Rat   106 SVVKQKLAEVIL-KKQQAALERTVHPSSPSIPYRTLEPLDTEGAARSVLSSFLP--PVPS----- 162

  Fly   235 IPQPPPSLLKYESDFPLRKTASEPNL-LKIRLKQSVIERK----ARIGGPAGARRH--ERLLQAA 292
            :|..||      ..||||||.||||| |:.:.|:|:..||    .:...|...||.  |.|..::
  Rat   163 LPTEPP------EHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSS 221

  Fly   293 QRRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQPGQRSSIN 357
                      .:.:|||.||.:||..          |...|..|       .||:...|||..:.
  Rat   222 ----------PSSSSTPASGCSSPND----------SEHGPNPA-------LGSEALLGQRLRLQ 259

  Fly   358 DLPL--FSSPS---LPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQG 417
            :..|  |:.|:   ||.|:||.|                   |.|:|....:.|:.........|
  Rat   260 ETSLAPFALPTVSLLPAITLGLP-------------------APARADGDRRTHSTLGPRGPVLG 305

  Fly   418 GCGQPGYYNPLGMAFV--GRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASL--VGDVAP 478
                    ||....|:  |.:|      .|.|..|.:..|::    ....|.|.|.|  |..:.|
  Rat   306 --------NPHAPLFLHHGLEP------EAGGTLPSRLQPIL----LLDPSVSHAPLWTVPGLGP 352

  Fly   479 PQAHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPH 543
            ...|.|..:|.:.        .::|||:
  Rat   353 LPFHFAQPLLTTE--------RLSGSGL------------------------------------- 372

  Fly   544 PHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNV 608
                                                  ||||.||:|.|||   |..|.:..|..
  Rat   373 --------------------------------------HRPLNRTRSEPLP---PSATASPLLGP 396

  Fly   609 VQTHYENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDS----AA 669
            :|...:..:...|          :.:|.::.....|..:....:..:..|:..|.|...    |.
  Rat   397 LQPRQDRLKPHVQ----------LIKTAISPPQRPAKPSEKPRLRQIPSAEDLETDGGGVGPMAN 451

  Fly   670 EVMDLTDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQE 734
            :.::..:..:.|                ||...|.:.....:.|                |.:|:
  Rat   452 DGLEHRESGRGP----------------PEGRGAVSLQQHQQVP----------------LWEQQ 484

  Fly   735 YLQQQREQ------LLLLQQEEELAKSLMRPLSRTLSSPLVPLG-----PHGLSQIPDTGQQPAP 788
            :|..:..|      :||     .||:...||||||.|||..|:.     |...:|:.::.:.||
  Rat   485 HLAGRLSQGGPGDSVLL-----PLAQIGHRPLSRTQSSPAAPVSLLSPEPTCQTQVLNSSEAPA- 543

  Fly   789 IATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCI 853
                                                              |||.||.:||||.|.
  Rat   544 --------------------------------------------------TGLVYDSVMLKHQCS 558

  Fly   854 CGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRP 918
            ||||::||||:||:||:|:||.|..|..:|:.||.|||:.||||:||:|.|.:|:|:|  .|||.
  Rat   559 CGDNSKHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTN--PLSRL 621

  Fly   919 KLEN------TLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFA 977
            ||:|      ....:||.|.|||:|||.||.|||.|::.|||.|||.|.|||.|.|..:|:||||
  Rat   622 KLDNGKLTGLLAQRTFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFA 686

  Fly   978 VVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILY 1042
            |||||||||:.:.|||||||||:|||.:.|:|. .:..:||||||||||||||||.|||.|.:||
  Rat   687 VVRPPGHHADHSTAMGFCFFNSVAIACRQLQQH-GKASKILIVDWDVHHGNGTQQTFYQDPRVLY 750

  Fly  1043 LSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNP 1107
            :|:|||||||||||:|...|.|:|:|.|||||::|:|.|:||:||.||:||||.|||||||.|.|
  Rat   751 ISLHRHDDGNFFPGSGAVDEVGTGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFAP 815

  Fly  1108 DIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECV 1172
            |:||||:|||||.||||||||||||..|||:||::|:.||.|.||||||||:||.||||:::.||
  Rat   816 DLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMSLAGGAVVLALEGGHDLTAICDASEACV 880

  Fly  1173 RALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVR--------MLEHTVGLSALETL 1229
            .||||:...|:::...::.|..|||.:|:..:.:.:.:|.|::        .|....|..|
  Rat   881 AALLGNKVDPLSQESWKQKPNLNAIRSLEAVVRVHRKYWGCMQRLASCPDPWLPRVPGADA---- 941

  Fly  1230 KVEHDESETINAMAGLSMQSMHRTLSRD-------DSEEPMD 1264
                 |.|.:.|:|.||:    ..|:.|       :.||||:
  Rat   942 -----EVEAVTALASLSV----GILAEDRPSKELMEEEEPMN 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
		HDAC_classIIa	837..1211	CDD:212544	228/379 (60%)
Hdac7	XP_008764065.1	Arginase_HDAC	544..919	CDD:302587	228/377 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119187at33208
OrthoFinder	1	1.000	-	-		FOG0001001
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910