DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and Hdac1l

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_445898.1	Gene:	Hdac1l / 84576	RGDID:	619975	Length:	484	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	110/457 - (24%)
Similarity:	185/457 - (40%)	Gaps:	106/457 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGS----NQCQLSR--- 917
            ||....|::.....|....|.::.:..|..||..||:...|::.:.....|    |..:.|:
  Rat    28 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQ 92

  Fly   918 --------PKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRN 974
                    |..:...  .|.:||.|| .|......|:..|..|...|.|.
  Rat    93 RFNVGEDCPVFDGLF--EFCQLSTGG-SVASAVKLNKQQTDIAVNWAGGL--------------- 139

  Fly   975 GFAVVRPPGHHAEANLAMGFCFFNSIAIA-AKLLRQRMPEVRRILIVDWDVHH--GNGTQQAFYQ 1036
                     |:|:.:.|.|||:.|.|.:| .:||:..    :|:|.:|.|:||  |:|.::|||.
  Rat   140 ---------HYAKKSEASGFCYVNDIVLAILELLKYH----QRVLYIDIDIHHGDGDGVEEAFYT 191

  Fly  1037 SPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPI 1101
            :..::.:|.|::  |.:|||||...:.|:|.|..:.||.    .|...:.|..|.|.|:.|:..:
  Rat   192 TDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNY----PLRDGIDDESYEAIFKPVMSKV 250

  Fly  1102 ARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------ELLQLANGKVVLALEGGYD 1160
            ...|.|..|::..|.|:.:|.  .||       ||....:      |.::..|..:::....||.
  Rat   251 MEMFQPSAVVLQCGSDSLSGD--RLG-------CFNLTIKGHAKCVEFVKSFNLPMLMLGGDGYT 306

  Fly  1161 L--AAICDSAQECVRALLGDPAAP-------------------IAKAELERPPCQNAINTLQKTI 1204
            :  .|.|.:.:..| ||  |...|                   |:.:.:..   ||....|:|
  Rat   307 IHNVARCWTYETAV-AL--DTEIPNELPYNDYFEYFGPDFKLHISPSNMTN---QNTNEYLEK-- 363

  Fly  1205 AIQQTHWPCVRMLEHTVG--LSAL--ETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQ 1265
             |:|..:..:|||.||.|  :.|:  :.:..|..:.:..:....:|:.|..:.::.:  ||..|.
  Rat   364 -IKQRLFENLRMLPHTPGVQMQAIPEDAIPEESGDEDEEDPDKPISICSSDKCIACE--EEFPDS 425

  Fly  1266 DE 1267
            ||
  Rat   426 DE 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	95/395 (24%)
Hdac1l	NP_445898.1	HDAC1	4..376	CDD:212534	97/402 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810