DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and HDA08

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_563817.1	Gene:	HDA08 / 837366	AraportID:	AT1G08460	Length:	377	Species:	Arabidopsis thaliana

Alignment Length:	432	Identity:	112/432 - (25%)
Similarity:	182/432 - (42%)	Gaps:	119/432 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   847 MLKHSCICG--DNA----------QHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTV 899
            ||:|..:.|  |..          :|||::.|::::.:.|....:....:......|...||...
plant    14 MLRHDAVEGVFDTGYDPGFLDVLEKHPENADRVRNMLSILRRGPIAPHVNWFTGLPAIVSELLMF 78

  Fly   900 HTEAHAMLF-----GSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGC 959
            ||..:....     ...:|:::        :.:|  :|.|        :|.      ||.:|||.
plant    79 HTSEYIEKLVEADKSGERCEIA--------AGTF--MSPG--------SWE------AALLAAGT 119

  Fly   960 -------VIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRI 1017
                   ::|...|.|       :|:|||||||::...|.|:||.|:.|:|.| |........|:
plant   120 TLSAMQHILDCHGKIA-------YALVRPPGHHSQPTQADGYCFLNNAALAVK-LALNSGSCSRV 176

  Fly  1018 LIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDD--GNFFPGTGGPTECGSGAGLGFNVNISWSGA 1080
            .::|.|||:||||.:.||.|..:|.:|:|.:..  |:..|..|...|.|...|||:|:|:
plant   177 AVIDIDVHYGNGTAEGFYTSDKVLTVSLHMNHGSWGSSHPQKGSIDELGEDVGLGYNLNV----- 236

  Fly  1081 LNPPL----GDAEYIAAFRTVVMPIARSFNPDIVLV-----SSGFDAATGHPAPLGGYHVSPACF 1136
               ||    ||..|..|...:|:|..|.|.||:|::     ||.||........:.||
plant   237 ---PLPNGTGDRGYEYAMNELVVPAVRRFGPDMVVLVVGQDSSAFDPNGRQSLTMNGY------- 291

  Fly  1137 GFMTRELLQL--------ANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPC 1193
                |.:.|:        ::|::::..||||.:.    .|..|:.|:| :....|.:..|..|
plant   292 ----RRIGQIMRGVAEEHSHGRLLMVQEGGYHVT----YAAYCLHAML-EGVLKIPEPHLSDP-- 345

  Fly  1194 QNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDE 1235
                      ||    ::|    .|....::|:|::|..|.|
plant   346 ----------IA----YYP----EEEANAVAAVESIKTYHTE 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	105/406 (26%)
HDA08	NP_563817.1	HDAC_classII_1	6..351	CDD:212521	106/412 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920