DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and HDA6

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_201116.1	Gene:	HDA6 / 836431	AraportID:	AT5G63110	Length:	471	Species:	Arabidopsis thaliana

Alignment Length:	467	Identity:	111/467 - (23%)
Similarity:	190/467 - (40%)	Gaps:	92/467 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   830 SGSPPHKVTTGLAYDPLMLKHSCICGD---NAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKA 891
            ||....|......|:|.:       ||   ...||....|::...:.:....|.:|.:..|...|
plant    12 SGPDGRKRRVSYFYEPTI-------GDYYYGQGHPMKPHRIRMAHSLIIHYHLHRRLEISRPSLA 69

  Fly   892 TQEELQTVHTEAHAMLFGS-NQCQLSRPKLENTLSASFVRLSC---GGLGVDLDTTWNEHHTATA 952
            ...::...|:..:.....| :...:..|.....|....|...|   .|| .|.
plant    70 DASDIGRFHSPEYVDFLASVSPESMGDPSAARNLRRFNVGEDCPVFDGL-FDF------------ 121

  Fly   953 ARMAAGCVIDLALKTAKGDLRNGFAVVRPPG-HHAEANLAMGFCFFNSIAIA-AKLLRQRMPEVR 1015
            .|.:||..|..|:|..:.|.  ..|:....| |||:.:.|.|||:.|.|.:. .:||:.    .:
plant   122 CRASAGGSIGAAVKLNRQDA--DIAINWGGGLHHAKKSEASGFCYVNDIVLGILELLKM----FK 180

  Fly  1016 RILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGA 1080
            |:|.:|.|||||:|.::|||.:..::.:|.|:.  |:||||||...:.|:..|..:.:|:    .
plant   181 RVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKF--GDFFPGTGHIRDVGAEKGKYYALNV----P 239

  Fly  1081 LNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVS----PACFGFMTR 1141
            ||..:.|..:.:.||.::..:...:.|:.|::..|.|:.:|.  .||.:::|    ..|..|
plant   240 LNDGMDDESFRSLFRPLIQKVMEVYQPEAVVLQCGADSLSGD--RLGCFNLSVKGHADCLRF--- 299

  Fly  1142 ELLQLANGKVVLALEGGYDL--AAICDSAQECVRALLGDP------------AAPIAKAELERPP 1192
              |:..|..:::...|||.:  .|.|...:..| |:..:|            ..|.....::..|
plant   300 --LRSYNVPLMVLGGGGYTIRNVARCWCYETAV-AVGVEPDNKLPYNEYFEYFGPDYTLHVDPSP 361

  Fly  1193 CQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRD 1257
            .:| :||.:....|:.|      :||...||....:::.:|             ...::|.|
plant   362 MEN-LNTPKDMERIRNT------LLEQLSGLIHAPSVQFQH-------------TPPVNRVL--- 403

  Fly  1258 DSEEPMDQDETK 1269
              :||.|..||:
plant   404 --DEPEDDMETR 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	96/400 (24%)
HDA6	NP_201116.1	HDAC_classI	24..331	CDD:212517	87/346 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810