DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and HDA18

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_200915.2	Gene:	HDA18 / 836228	AraportID:	AT5G61070	Length:	682	Species:	Arabidopsis thaliana

Alignment Length:	485	Identity:	167/485 - (34%)
Similarity:	261/485 - (53%)	Gaps:	49/485 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   799 PPVNLS------LPHRQHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGD- 856
            |.|:|:      |.|.....:.|.....:........:|....||  ||.||..|.||....|.
plant    16 PSVSLTVLRKIRLSHLPDMTMTSESSGKKCGEGDGKVAGKSQRKV--GLVYDETMCKHDTPNGKV 78

  Fly   857 NAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLE 921
            :.:.|:   |::.:|.:|....:.:||..|...||..:.|:.|||:.|..|..|    :|..|.:
plant    79 DVECPD---RIRVIWEKLQLAGVTQRCVVLGGSKAEDKHLKLVHTKKHVNLVKS----ISTKKKD 136

  Fly   922 NTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHA 986
            :..:.         :...||:.:....::.||.:|||.|:.:|.|.|:|:|..|||:||||||||
plant   137 SRRNK---------IASQLDSIYLNGGSSEAAYLAAGSVVKVAEKVAEGELDCGFAIVRPPGHHA 192

  Fly   987 EANLAMGFCFFNSIAIAAKLLRQRMP--EVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHD 1049
            |::.|||||.||::|:||..|....|  :|::|||||||:|||||||:.|::...:|..|:||||
plant   193 ESDEAMGFCLFNNVAVAASFLLNERPDLDVKKILIVDWDIHHGNGTQKMFWKDSRVLIFSVHRHD 257

  Fly  1050 DGNFFP-GTGGP-TECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLV 1112
            .|:|:| |..|. ...|.|.|.|||:|:.|.   ....|||:|:|.:..:::|:.:.|.|||:|:
plant   258 HGSFYPFGDDGDFNMVGEGPGEGFNINVPWE---QGGCGDADYLAVWNHILIPVTKEFKPDIILL 319

  Fly  1113 SSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLG 1177
            |:|||||.|.  ||||..|:|..:..|.::|::.|:||:||||||||:|.::..|:..||:.||.
plant   320 SAGFDAAIGD--PLGGCCVTPYGYSVMLKKLMEFAHGKIVLALEGGYNLESLGKSSLACVQVLLE 382

  Fly  1178 DPAAPIAKAELERPPCQNAINTLQKTIAIQQ---THWPCVRMLEHTVGLSALETLKVEHDESETI 1239
            |..   .....|..|.::....:|   |:::   |:||.:     ...:::.|.||....|..:.
plant   383 DKQ---IHGSSETYPLESTRRVIQ---AVRERLCTYWPSL-----DASMASNENLKNPSAERNSA 436

  Fly  1240 NAMAGLSMQSMHRTLSRDDSEEPMDQDETK 1269
            :|:. ..::.:...::..|.|....:.|.|
plant   437 DALL-REVEELKSLMAARDGELEARRKELK 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	148/381 (39%)
HDA18	NP_200915.2	Arginase_HDAC	64..416	CDD:418394	147/378 (39%)
HDA18	NP_200915.2	Smc	<371..632	CDD:224117	22/107 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720