DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HDAC4 and HDA05

DIOPT Version :9

Sequence 1:NP_001259507.1 Gene:HDAC4 / 32278 FlyBaseID:FBgn0041210 Length:1269 Species:Drosophila melanogaster
Sequence 2:NP_001190583.1 Gene:HDA05 / 836227 AraportID:AT5G61060 Length:664 Species:Arabidopsis thaliana


Alignment Length:464 Identity:170/464 - (36%)
Similarity:256/464 - (55%) Gaps:69/464 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   830 SGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQE 894
            :|:...||  ||.||..|.||.  ..|...|||...|::.:|.:|....:.:||..|.:.||..:
plant    20 AGNRQRKV--GLIYDETMCKHD--TPDGEDHPECPDRIRVIWEKLQLAGVSQRCVVLGSSKAEDK 80

  Fly   895 ELQTVHTEAHAML---FGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMA 956
            .||.|||:.|..|   ..:.|....|.::.:.|::.::.   ||             ::.||.:|
plant    81 HLQLVHTKDHVNLVKSISTKQKDYRRNRIASQLNSIYLN---GG-------------SSEAAYLA 129

  Fly   957 AGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPE--VRRILI 1019
            ||.|:.||.|.|:|:|..|||:||||||||||:.|||||.||::|:||..|....|:  |::|||
plant   130 AGSVVKLAEKVAEGELDCGFAIVRPPGHHAEADEAMGFCLFNNVAVAASFLLNERPDLGVKKILI 194

  Fly  1020 VDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPG--TGGPTECGSGAGLGFNVNISWSGALN 1082
            ||||||||||||:.|::.|.:|:.|:|||:.|.|:|.  .|.....|.|.|.|||:|:.|.   .
plant   195 VDWDVHHGNGTQKMFWKDPRVLFFSVHRHEYGGFYPAGDDGDYNMVGEGPGEGFNINVPWD---Q 256

  Fly  1083 PPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR----EL 1143
            ...|||:|:||:..:::|:||.||||::.:|:|||||...  ||||..|:|..:..|.:    ||
plant   257 GRCGDADYLAAWDHILIPVAREFNPDVIFLSAGFDAAIND--PLGGCCVTPYGYSVMLKKVGVEL 319

  Fly  1144 LQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPP-------CQNAINTLQ 1201
            ::.|.||:||||||||:|.:|..|:..||:.||.|       .:::.||       ....|..::
plant   320 MEFAQGKIVLALEGGYNLDSIAKSSLACVQVLLED-------KQIQGPPEAYPFESTWRVIQAVR 377

  Fly  1202 KTIAIQQTHWPCV------RMLEHTVGLSALETLKVEHDESET-------INAMAGLSMQSMHRT 1253
            |.:.   |:||.:      :::...   :....:.:...:|||       ::.|:.||:::...|
plant   378 KRLC---TYWPSLADELSWKLINQK---TPTPIILISSSDSETEDNAQGLLDQMSKLSIENPQGT 436

  Fly  1254 LSRDDSEEP 1262
            |..:...||
plant   437 LLENHQVEP 445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC4NP_001259507.1 iSH2_PI3K_IA_R 43..>87 CDD:304922
HDAC_classIIa 837..1211 CDD:212544 156/391 (40%)
HDA05NP_001190583.1 Arginase_HDAC 31..388 CDD:302587 155/389 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1484694at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100220
Panther 1 1.100 - - O PTHR48252
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.820

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