DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and HDA2

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_568480.2	Gene:	HDA2 / 832673	AraportID:	AT5G26040	Length:	387	Species:	Arabidopsis thaliana

Alignment Length:	443	Identity:	91/443 - (20%)
Similarity:	142/443 - (32%)	Gaps:	165/443 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   789 IATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHKVTT--GLAYDPLMLKHS 851
            |::.|.|.|  |..|    |:.|.|.|.||..           .|..||:.  ..:||...:
plant    43 ISSFSMATH--PEAL----RRERILNSKLYFD-----------VPLSKVSIIYSSSYDISFM--- 87

  Fly   852 CICGDNAQHPEHSGRLQSVWAR----------LNETDLVKRCDRLRARKATQEELQTVHTEAHAM 906
               |....||..|    |.|.|          |.|..:|:..:      |::.:|..||:|.:.
plant    88 ---GIEKLHPFDS----SKWGRVCKFLVSDGFLEEKAIVEPLE------ASKIDLLVVHSENYL- 138

  Fly   907 LFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARM---------------- 955
                           |:|.:|                      ||.||:
plant   139 ---------------NSLKSS----------------------ATVARITEVAPVAFFPNFLVQQ 166

  Fly   956 ---------AAGCVIDLALKTAKG---DLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLR 1008
                     ..|.::...|.|.:|   ::..||       ||..|....|||.|..|::......
plant   167 KVLYPFRKQVGGTILAAKLATERGWAINIGGGF-------HHCTAERGGGFCAFADISLCIHFAF 224

  Fly  1009 QRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIH------------RHDDGNFFPGTGGPT 1061
            .|: .:.|::|:|.|.|.|||.:........:..|.::            |..|......:|..|
plant   225 LRL-RISRVMIIDLDAHQGNGHETDLGDDNRVYILDMYNPEIYPFDYRARRFIDQKVEVMSGTTT 288

  Fly  1062 ECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPL 1126
            :                          ||:......:...:|:|.|::|:.::|.|...|.  ||
plant   289 D--------------------------EYLRKLDEALEVASRNFQPELVIYNAGTDILDGD--PL 325

  Fly  1127 GGYHVSPACFGFMTRELLQLANGK---VVLALEGGY---DLAAICDSAQECVR 1173
            |...:||........::.:.|..|   :|:...|||   ....|.||.:...|
plant   326 GLLKISPDGITSRDEKVFRFAREKNIPLVMLTSGGYMKSSARVIADSIENLSR 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	77/395 (19%)
HDA2	NP_568480.2	HDAC_classIV	93..376	CDD:212519	72/366 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810