DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and HDA14

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_567921.1	Gene:	HDA14 / 829484	AraportID:	AT4G33470	Length:	423	Species:	Arabidopsis thaliana

Alignment Length:	386	Identity:	123/386 - (31%)
Similarity:	196/386 - (50%)	Gaps:	45/386 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   841 LAYDPLMLKHSCICGDNAQ-HPEHSGRLQSVWARLNETDLVKR------CDRLRARKATQEELQT 898
            ||...|:...|...|.|.: |||.|.|:.::...|...:|..:      .:....:.||.|::..
plant    60 LADARLIYSVSAALGHNKESHPECSARVPAIVNALEMNELTPKFRGSQILELANFKTATVEDIAN 124

  Fly   899 VHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDL 963
            ||.:|:  :||..:.      ::....:..:.:...|......||:.:...|..|.||   ::|.
plant   125 VHDKAY--VFGLEKA------MDEASDSGLIFIEGSGPTYATSTTFQDSLIAAGAGMA---LVDS 178

  Fly   964 ALKTAKG--DLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHH 1026
            .:..::.  |...|||::|||||||.....||||.|.::||||: ..||...::||.|:|:||||
plant   179 VIAASRNSVDPPIGFALIRPPGHHAVPKGPMGFCVFGNVAIAAR-HAQRTHGLKRIFIIDFDVHH 242

  Fly  1027 GNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYI 1091
            ||||..||.:.|||.:||.|:  ||: :||||..::.|.|.|.|..:|:...|.    .||....
plant   243 GNGTNDAFTEDPDIFFLSTHQ--DGS-YPGTGKISDIGKGKGEGTTLNLPLPGG----SGDIAMR 300

  Fly  1092 AAFRTVVMPIARSFNPDIVLVSSGFDAATGHPA-PLGGYHVSPACFGFMTRELLQLA----NGKV 1151
            ..|..:::|.|:.|.|||:|||:|:||   |.. ||.....:.|.:..:.:::.:||    .|:.
plant   301 TVFEEIIVPCAQRFKPDIILVSAGYDA---HVLDPLANLQFTTATYYSLAKDIKRLAKEVCGGRC 362

  Fly  1152 VLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERP------PCQNAINTLQKTIAI 1206
            |..|||||:|.::..|..:..|||||:.:   ..:|.:.|      |.:...:.:|:..:|
plant   363 VFFLEGGYNLESLSSSVADSFRALLGEDS---LASEFDNPAYLYDEPMRKVRDAIQRAKSI 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	123/386 (32%)
HDA14	NP_567921.1	HDAC_classII	80..387	CDD:212518	109/328 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820